Results 181 to 190 of about 5,200,432 (243)

Tumour‐induced hypoglycaemia due to ‘big’ IGF–II

Journal of Internal Medicine, 1994
Abstract. A 57‐year‐old woman with a slowly growing intraabdominal leiomyosarcoma developed life‐threatening hypoglycaemia. Plasma C‐peptide levels were low (0.08 nmol L‐1 and < 0.05 nmol L‐1, reference interval 0.18–0.63 nmol L‐1). Total IGF–II was normal (760 ng mL‐1) whilst ‘big’ IGF–II was markedly elevated (440 ng mL‐1).
G, Strauss, L, Christensen, J, Zapf
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Expression of IGF-II, the IGF-II/Mannose-6-Phosphate Receptor and IGFBP-2 During Rat Embryogenesis

1991
It is becoming increasingly apparent that the IGF system (including both IGF-I and IGF-II, at least two IGF receptors, and a family of at least six IGF binding proteins; 1-3) has a fundamental role in the normal progression of prenatal development. The initial observation that IGF-II peptide levels were high in the fetus but decreased post-natally (4 ...
J E, Pintar, T L, Wood, R D, Streck, L, Havton, L, Rogler, M S, Hsu   +5 more
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Insulin-Like Growth Factor II (IGF-II) and the IGF-II/ Mannose-6-Phosphate Receptor: The Myth Continues

Hormone Research, 1994
Insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin. It is now thought that IGF-II acts as a growth factor during fetal life and development. In rats, IGF-II levels in the circulation are high in the fetus and decline rapidly after birth.
W, Kiess, Y, Yang, U, Kessler, A, Hoeflich   +3 more
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Purification and characterization of insulin-like growth factor II (IGF II) and an IGF II variant from human placenta

Journal of Chromatography B: Biomedical Sciences and Applications, 1995
In order to purify variant IGF II peptides from human placenta, we have developed a purification procedure combining heparin affinity chromatography and cation-exchange, reversed-phase and size-exclusion HPLC. Two peptides were purified, both having apparent M(r) values of ca. 7300 Da as evaluated by SDS-PAGE.
F, De Ceuninck, J, Willeput, M, Corvol
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IGF‐I, IGF‐II, and IGF‐receptor‐1 transcript and IGF‐II protein expression in myostatin knockout mice tissues

Muscle & Nerve, 2002
AbstractSemiquantitative reverse transcriptase–polymerase chain reaction (RT‐PCR) and immunohistochemistry were performed to demonstrate whether a correlation exists between insulin‐like growth factors (IGFs)—positive regulators of growth—and myostatin, a negative regulator of muscle growth.
Hakan, Kocamis, Scott A, Gahr, Lori, Batelli, Ann F, Hubbs, John, Killefer   +4 more
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Human colon carcinoma cells ( CaCo-2) synthesize IGF-II and express IGF-I receptors and IGF-II/M6P receptors

Molecular and Cellular Endocrinology, 1994
The IGFs have been implicated in the development of the intestinal tract. We have studied the human colon carcinoma cell line CaCo-2 to gain more insight into the function of the IGFs in the gut. [125I]IGF-I and -II bound specifically to CaCo-2 cells as measured in competitive binding experiments.
A, Hoeflich, Y, Yang, U, Kessler, P, Heinz-Erian, H, Kolb, W, Kiess   +5 more
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Tumor Hypoglycemia Linked to IGF-II

1999
Hypoglycemia is a common medical emergency, most often due to untoward effects of insulin administered to patients with diabetes mellitus. It is also a manifestation of many other medical conditions including tumors. The hypoglycemia associated with tumors occurs within a subset of patients who have “spontaneous” or fasting hypoglycemia, i.e., the fall
Christian A. Koch, Kristina I. Rother, Jesse Roth   +2 more
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Role of the IGF‐II receptor in mediating acute, non‐genomic effects of retinoids and IGF‐II on keratinocyte cell death

Experimental Dermatology, 2003
Abstract:  In this study, we have examined the effects of retinoic acid (RA) on the human immortalized keratinocyte cell line (HaCaT). A significant twofold (P < 0.01) increase in apoptotic cell death compared with the control was found within 24 h of treatment with 10−5 M of RA. Apoptosis was confirmed by flow cytometry.
Louafi, F., Stewart, Claire E., Perks, C. M., Thomas, M. G., Holly, Jeff   +4 more
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“Big IGF-II”-induced hypoglycemia secondary to gastric adenocarcinoma

Diabetes & Metabolism, 2004
Non-islet cell tumor-related hypoglycemia is a rare phenomenon. We report the case of a 63 Year-old man admitted for hemiparesia and a capillary blood glucose of 20 mg/dL. The presence of an immature form of IGF-II that can mimic the effect of insulin, namely "big IGF-II", explained this patient's hypoglycaemia.
L, Morbois-Trabut, F, Maillot, A, De Widerspach-Thor, F, Lamisse, C, Couet   +4 more
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PL06 IGF-II and feto-placental growth

Growth Hormone & IGF Research, 2012
Prolactin was discovered more than 80 years ago. It is currently viewed by clinical endocrinologists as a hormone of pituitary origin, whose biological actions relate exclusively to lactation and reproductive functions, for which any genetic disorder is yet to be identified, and whose unique associated pathology is hyperprolactinemia, which is ...
M. Constância, I. Zvetkova, Y. Sekita, C. Hammerle, W. Cooper, I. Sandovici   +5 more
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