Results 171 to 180 of about 7,271 (197)

HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription

Clinical and Translational Oncology, 2023
Pancreatic cancer is a devastating and lethal malignancy. Our study investigated the effective mechanism of HNF4G on pancreatic cancer cell functions through the IGF2BP2 transcription.HNF4G and IGF2BP2 expressions in pancreatic cancer were examined.
Jian Zhan, Qian Zhang, Xu Tong, Xu Liu, Chunbo Zhao   +4 more
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The m6A Reader IGF2BP2 Regulates Macrophage Phenotypic Activation and Inflammatory Diseases by Stabilizing TSC1 and PPARγ [PDF]

Advanced Science, 2021
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Currently, little is known about how the intrinsic regulators modulate proinflammatory (M1) versus prohealing (M2) macrophages activation. Here,
Dawei Chen, Yaxun Wei, Yaqiang Xue
exaly   +2 more sources

IGF2BP2 promotes the progression of colorectal cancer through a YAP-dependent mechanism [PDF]

Cancer Science, 2021
AbstractTo explore the effect of insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) on colorectal cancer (CRC) by recognizing the m6A modification of YAP mRNA thus activating ErbB2 expression. High expressions of IGF2BP2, YAP, and ErbB2 promoted the proliferation, migration and invasion of CRC cells and reduced their apoptosis.
Weiwei Wang, Jian Wu, Anquan Shang
exaly   +3 more sources

The Diverse Functions of IMP2/IGF2BP2 in Metabolism

Trends in Endocrinology & Metabolism, 2020
The human insulin-like growth factor 2 (IGF2) mRNA binding protein family (IMPs/IGF2BPs) is involved in a spectrum of biological processes, including development, tumorigenesis, and stemness. IMPs play a major role in post-transcriptional regulation of RNAs through the ribonucleoprotein complex (RNP).
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Dual Role of IGF2BP2 in Osteoimmunomodulation during Periodontitis

Journal of Dental Research
Periodontitis is a complex disease characterized by distinct inflammatory stages, with a peak of inflammation in the early phase and less prominent inflammation in the advanced phase. The insulin-like growth factor 2-binding proteins 2 (IGF2BP2) has recently been identified as a new m 6 A ...
X.X. Ma, X.Y. Zhou, M.G. Feng, Y.T. Ji, F.F. Song, Q.C. Tang, Q. He, Y.F. Zhang   +7 more
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IGF2BP2 is Induced by Stress in the Heart and Mediates Dilated Cardiomyopathy

2022
Abstract The IGF2BP family of RNA binding proteins consists of three paralogs that regulate intracellular RNA localization, RNA stability, and translational control. Although IGF2BP1 and 3 are oncofetal proteins, IGF2BP2 expression is maintained in many tissues, including the heart, into adulthood.
Miriam Krumbein, Froma Oberman, Yuval Cinnamon, Mordechai Golomb, Dalit May, Gilad Vainer, Vitali Belzer, Karen Meir, Irina Fridman, Johannes Haybaeck, Gerhard Poelzl, Izhak Kehat, Ronen Beeri, Sonja Kessler, Joel K. Yisraeli   +14 more
openaire   +1 more source

IGF2BP2 gene polymorphism in patients with psoriasis

2020
We thank the Firat University, Scientific Research Projects Unit (FUSRP, Project number: TF.14.74) for their contributions to this study. This study has been presented in the National Medical Biology and Genetics Congress held at Fethiye/Mugla from 27-30 October 2015, numbered PS-0735.
Kargun, Kursat, Demir, Betul, Cicek, Demet, Kara, Murat, Bilik, Leyla, Kaya, Haktan   +5 more
openaire   +2 more sources

Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk

Acta Diabetologica, 2011
Insulin-like growth factor 2 mRNA-binding protein 2 (IFG2BP2) belongs to an mRNA-binding protein family involved in the development and stimulation of insulin action, which has attracted considerable attention as a candidate gene for type 2 diabetes (T2D) since it was first identified through genome-wide association approach.
Jie, Wu, Junjie, Wu, Yuhao, Zhou, Houdong, Zou, Shicheng, Guo, Jie, Liu, Liwen, Lu, Hao, Xu   +7 more
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IGF2BP2 gene polymorphism in patients with morbid obesity

2020
Background/Aim: In this study, it was aimed to determine the relationship between morbid obesity and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs1470579 and rs4402960 gene polymorphisms. Materials and methods: Data from 100 consecutive patients who underwent surgery due to morbid obesity (MO) and 100 healthy volunteers with normal ...
Kargün, Kürşat, Şenol, Sefa, Kırkıl, Cüneyt, Çambay, Zafer, Kara, Murat, Aygen, Erhan, Yılmaz, Mustafa   +6 more
openaire   +1 more source

Functional characterization of IGF2BP2, a diabetes-susceptibility gene

2011
This thesis is not available on this repository until the author agrees to make it public. If you are the author of this thesis and would like to make your work openly available, please contact us: thesis@repository.cam.ac.uk.
openaire   +2 more sources