Results 31 to 40 of about 45,932 (257)

Plasma Insulin-like Growth Factor-Binding Protein-2 of Critically Ill Patients Is Related to Disease Severity and Survival

Biomedicines, 2023
Insulin-like growth factor-binding protein (IGFBP)-2 regulates the bioactivity of the anabolic hormone’s insulin-like growth factors, which are decreased in sepsis and contribute to the catabolic status of severely ill patients. The circulating levels of
Patricia Mester, Ulrich Räth, Luisa Popp, Stephan Schmid, Martina Müller, Christa Buechler, Vlad Pavel   +6 more
doaj   +1 more source

The insulin-like growth factor system and the progression of renal complications of type 2 diabetes. [PDF]

Diabet Med
Abstract Aims Chronic kidney disease is associated with dysregulation of the insulin‐like growth factor (IGF) system. Alterations in IGF bioavailability, driven by IGF binding proteins (IGFBPs), may influence the decline in renal function. However, the longitudinal relationship between baseline IGF‐I, IGF‐II, IGFBPs and progression of kidney ...
Heald A, Lllangasekera Y, Matheou A, Narayanan RP, White S, Habte-Asres H, Lay A, Shalamanova L, Ollier W, Hitman GA, Mallik R, Kalra PA, Whyte M, Gibson JM.   +13 more
europepmc   +2 more sources

Investigation of different molecular forms of IGFBP-1 using immobilised metal-, immuno- and lectin-affinity chromatography [PDF]

Journal of the Serbian Chemical Society, 2010
Insulin-like growth factor-binding protein 1 (IGFBP-1) is a member of a family of six homologous proteins that regulate the action of the insulin-like growth factors.
Lagundžin Dragana, Masnikosa Romana, Miljuš Goran, Robajac Dragana, Nedić Olgica   +4 more
doaj   +1 more source

IGFBP-2 Signaling in the Brain: From Brain Development to Higher Order Brain Functions

Frontiers in Endocrinology, 2019
Insulin-like growth factor-binding protein-2 (IGFBP-2) is a pleiotropic polypeptide that functions as autocrine and/or paracrine growth factors. IGFBP-2 is the most abundant of the IGFBPs in the cerebrospinal fluid (CSF), and developing brain showed the ...
Shumsuzzaman Khan
semanticscholar   +1 more source

Correlation of tri-ponderal mass index with insulin-like growth factor-I and insulin-like growth factor binding protein-3 in children and adolescents [PDF]

Annals of Pediatric Endocrinology & Metabolism
Purpose We aimed to investigate the relationship between the tri-ponderal mass index (TMI), a new indirect measure of fat mass, and insulin-like growth factor (IGF)-I/IGF binding protein (IGFBP)-3.
Iee Ho Choi, Sun-Young Kim, Minsun Kim
doaj   +1 more source

IGFBP-2 and aging: a 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population

European Journal of Endocrinology, 2019
Objective: Insulin-like growth factor-binding protein-2 (IGFBP-2) concentrations are low in subjects with metabolic syndrome and type 2 diabetes. Intriguingly, recent studies have demonstrated an association between high IGFBP-2 concentrations and ...
A. W. van den Beld, O. Carlson, M. Doyle, D. Rizopoulos, L. Ferrucci, A. J. van der Lely, J. Egan   +6 more
semanticscholar   +1 more source

Insulin-like Growth Factor Binding Protein 7 Mediates Glioma Cell Growth and Migration

Neoplasia: An International Journal for Oncology Research, 2008
Insulin-like growth factor binding protein 7 (IGFBP-7) is the only member of the IGFBP superfamily that binds strongly to insulin, suggesting that IGFBP-7 may have different functions from other IGFBPs.
Wei Jiang, Cunli Xiang, Simona Cazacu, Chaya Brodie, Tom Mikkelsen   +4 more
doaj   +1 more source

Evolution of ancient functions in the vertebrate insulin-like growth factor system uncovered by study of duplicated salmonid fish genomes [PDF]

, 2013
This work was supported by the Marine Alliance for Science and Technology for Scotland pooling initiative, funded by the Scottish Funding Council (grant number HR09011) and contributing institutions.Whole genome duplication (WGD) was experienced twice by
Macqueen, Daniel J, MacQueen, Daniel John, de la Serrana, Daniel Garcia, Johnston, Ian Alistair, Garcia de la Serrana, Daniel, Garcia de la Serrana Castillo, Daniel, Johnston, Ian A   +6 more
core   +1 more source

IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators

Frontiers in Endocrinology, 2018
Pulmonary fibrosis is a hallmark of diseases such as systemic sclerosis (SSc, scleroderma) and idiopathic pulmonary fibrosis (IPF). To date, the therapeutic options for patients with pulmonary fibrosis are limited, and organ transplantation remains the ...
Xinh‐Xinh Nguyen, Lutfiyya N Muhammad, P. Nietert, C. Feghali-Bostwick   +3 more
semanticscholar   +1 more source

Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]

, 2005
We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Beattie, J, Whitelaw C. B. A., ACCORSI, PIER ATTILIO, Hurley, W, Boutinaud, M, Kolb A., Allan G. A., Tonner, E, Wilde, C J, Boutinaud M., Wilde C. J., Beattie J., Accorsi, P A, Flint, D J, Flint D. J., Tonner E., Whitelaw, C B A, Hurley W., Kolb, A F, Allan, G J   +19 more
core   +1 more source