Results 21 to 30 of about 45,932 (257)

Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3): Unraveling the Role in Mediating IGF-Independent Effects Within the Cell

Frontiers in Cell and Developmental Biology, 2020
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3), one of the six members of the IGFBP family, is a key protein in the IGF pathway. IGFBP-3 can function in an IGF-dependent as well as in an IGF-independent manner.
Shailly Varma Shrivastav, Apurva Bhardwaj, K. Pathak, A. Shrivastav   +3 more
semanticscholar   +1 more source

Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity [PDF]

, 1995
PhDThe insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development.
Yateman, Martin Edward
core   +4 more sources

The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease

Frontiers in Endocrinology, 2020
The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that
W. Stuard, Rossella Titone, Danielle M. Robertson   +2 more
semanticscholar   +1 more source

IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells

Journal of Cancer Research and Clinical Oncology, 2012
Shuguang Zuo, Wenjuan Fan
exaly   +2 more sources

Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2013
Insulin-like growth factor binding protein (IGFBP)-3 has roles in modulating the effect of IGFs by binding to IGFs and inhibiting cell proliferation in an IGF-independent manner.
Ho-Seong Kim
doaj   +1 more source

Adiponectin, IGFBP-1 and -2 are independent predictors in forecasting prediabetes and type 2 diabetes

Frontiers in Endocrinology, 2023
ObjectiveAdiponectin and insulin-like growth factor (IGF) binding proteins IGFBP-1 and IGFBP-2 are biomarkers of insulin sensitivity. IGFBP-1 reflects insulin sensitivity in the liver, adiponectin in adipose tissue and IGFBP-2 in both tissues.
Kerstin Brismar, Kerstin Brismar, Agneta Hilding, Ishrath Ansurudeen, Allan Flyvbjerg, Jan Frystyk, Jan Frystyk, Claes-Göran Östenson, Claes-Göran Östenson   +8 more
doaj   +1 more source

Pre- and Postoperative Circulating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine Treatment and Breast Cancer Recurrence: A Nested Case-Control Study

Frontiers in Oncology, 2021
Insulin-like growth factor-I (IGF-I) and its binding proteins (BPs) have been associated with breast cancer risk, especially high IGF-I concentrations and the biologically active fraction estimated as the IGF-I/IGFBP-3 molar ratio.
Ann H. Rosendahl, Sofie Björner, Maria Ygland Rödström, Karin Jirström, Signe Borgquist, Signe Borgquist, Christian Ingvar, Michael N. Pollak, Helena Jernström   +8 more
doaj   +1 more source

Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish. [PDF]

PLoS ONE, 2008
Gene duplication is the primary force of new gene evolution. Deciphering whether a pair of duplicated genes has evolved divergent functions is often challenging.
Hiroyasu Kamei, Ling Lu, Shuang Jiao, Yun Li, Claus Gyrup, Lisbeth S Laursen, Claus Oxvig, Jianfeng Zhou, Cunming Duan   +8 more
doaj   +1 more source

Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. [PDF]

PLoS ONE, 2008
BACKGROUND: Insulin-like growth factor binding protein-2 (IGFBP-2) is a secreted protein that binds and regulates IGF actions in controlling growth, development, reproduction, and aging. Elevated expression of IGFBP-2 is often associated with progression
Jianfeng Zhou, Wenhong Li, Hiroyasu Kamei, Cunming Duan   +3 more
doaj   +1 more source

Organ-Specific Modulation of IGF-Binding Proteins in Malnourished Mice Supplemented with Probiotics: A Proteomic Approach [PDF]

BIO Web of Conferences
Malnutrition disrupts the insulin-like growth factor (IGF) axis, impairing systemic growth and brain function. This study quantitatively assessed IGF-binding protein (IGFBP) expression in the liver and brain of malnourished mice following probiotic ...
Sulastri Afianti, Cakrawati Dewi, Azis Aldi Maulana   +2 more
doaj   +1 more source