Results 1 to 10 of about 45,932 (257)
IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer
Cells, 2020 Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are IGFBP-1 through 6, IGFBP-3 is the most extensively investigated ...
Mikhail G Dozmorov, Youngman Oh
exaly +5 more sources
IGFBP-2 Directly Stimulates Osteoblast Differentiation [PDF]
Journal of Bone and Mineral Research, 2014 Insulin‐like growth factor binding protein 2 (IGFBP‐2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP‐2 functions is not defined.
Gang Xi, Clifford J Rosen, Christine Wai
exaly +3 more sources
Circulating salmon 41-kDa insulin-like growth factor binding protein (IGFBP) is not IGFBP-3 but an IGFBP-2 subtype. [PDF]
General and Comparative Endocrinology, 2011 In vertebrates, most circulating insulin-like growth factor (IGF) is bound to multiple forms of IGF-binding proteins (IGFBPs) that differ both structurally and functionally. In mammals, the largest reservoir of IGF in the circulation comes from a large (150kDa) ternary complex comprised of IGF bound to IGFBP-3, which is bound to an acid label subunit ...
M. Shimizu +4 more
semanticscholar +7 more sources
Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis [PDF]
BMC Pulmonary Medicine, 2016 BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic lung disorder of unknown origin, which ultimately leads to death. Several growth factors such as IGFs (insulin-like-growth factor) and IGFBPs (insulin like growth factor binding proteins) seem to
J. Guiot +4 more
semanticscholar +5 more sources
British Journal of Cancer, 2014 Background:Insulin-like growth factor binding protein-2 (IGFBP-2) is significantly increased in the serum of patients with malignant gliomas. High plasma IGFBP-2 levels are correlated with poor prognosis in glioma patients.
Sheng Han +4 more
exaly +2 more sources
IGF-II, IGFBP-4, -6, and -7, and HMGB1 show changes in follicular fluid in PCOS [PDF]
Frontiers in EndocrinologyIntroductionPolycystic ovary syndrome (PCOS) is a multisystem endocrine and metabolic disease characterized by chronic low-grade inflammation, ovulatory dysfunction, hyperandrogenism, and insulin resistance.
Veronica Buia +14 more
doaj +2 more sources
IGFBP-6 regulates SH2D4A expression to promote breast cancer cell cycle progression in response to progesterone [PDF]
Frontiers in EndocrinologyInsulin-like growth factor binding protein-6 (IGFBP-6) is induced by progesterone in breast cancer cells and regulates progesterone receptor (PR) via negative feedback.
Francisco J. Lariz +3 more
doaj +2 more sources
Journal of Biological Chemistry, 2010 Insulin-like growth factor-binding protein-3 (IGFBP-3), a major regulator of endocrine actions of IGFs, is a p53-regulated potent apoptotic factor and is significantly suppressed in a variety of cancers.
Youngman Oh +2 more
exaly +2 more sources
The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2009 AbstractCirculating concentrations of insulin-like growth factor I (IGF-I) and IGF binding proteins (IGFBP) have been associated with the risk of several types of cancer. Dietary correlates of IGF-I and IGFBPs are not yet well established. The objective of this study was to assess the association between dietary intake and serum concentrations of IGF-I,
F. Crowe +43 more
semanticscholar +8 more sources
Южно-Российский онкологический журнал, 2023 Purpose of the study. An analysis of IGF and their carrying proteins levels in blood serum of patients with non‑small cell lung cancer (NSCLC), depending on the severity of the previous COVID-19 infection.Materials and methods.
O. I. Kit +9 more
doaj +1 more source