Results 11 to 20 of about 45,932 (257)

The Value of IGF-1 and IGFBP-1 in Patients With Heart Failure With Reduced, Mid-range, and Preserved Ejection Fraction [PDF]

Frontiers in Cardiovascular Medicine, 2022
BackgroundPrevious studies have reported inconsistent results regarding the implications of deranged insulin-like growth factor 1 (IGF-1)/insulin-like growth factor-binding protein 1 (IGFBP-1) axis in patients with heart failure (HF).
Shaohua Guo, Mengqi Gong, Gary Tse, Gary Tse, Gary Tse, Guangping Li, Kang-Yin Chen, Tong Liu   +7 more
doaj   +2 more sources

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]

, 2005
We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Clegg, R.A., Kelly, S.M., Allan, G.J., Flint, D.J., Shand, J., Beattie, J., Gow, I.F., Tonner, E., Szymanowska, M., Phillips, K.   +9 more
core   +4 more sources

IGFBP-5 enhances epithelial cell adhesion and protects epithelial cells from TGFβ1-induced mesenchymal invasion [PDF]

, 2013
TGFβ1 is a major fibrotic factor and its actions involve induction of epithelial cell death, together with the stimulation and transdifferentiation of fibroblasts into collagen- and fibronectin-secreting myofibroblasts.
Kaziri, I., Kaziri, I, Mooney, CC, Sureshbabu, A., Sureshbabu, A, Vijayan, A., Vijayan, A, Flint, DJ, Guha, D, Edwards, J, Beattie, J., Ameer, F, Fasal, A, Beattie, J, Mooney, C.C., Mooney, C C, Ameer, F., Allan, G.J., Flint, D.J., Guha, D., Tonner, E., Allan, GJ, Bennett, L., Tonner, E, Bennett, L, Edwards, J., Flint, D J   +26 more
core   +4 more sources

IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis

International Journal of Molecular Sciences, 2022
Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the immune response, particularly in human dendritic cells (DCs).
A. Liso, Santina Venuto, A. R. Coda, C. Giallongo, G. Palumbo, D. Tibullo   +5 more
semanticscholar   +1 more source

Insulin-like growth factors and their transporter proteins in the liver of rats with experimental diabetes, adenocarcinoma of the uterine corpus, and their combination

Бюллетень сибирской медицины, 2022
Aim. To investigate the content of insulin-like growth factor (IGF)-1, IGF-2, and their transporter proteins IGFBP-1 and IGFBP in the liver of rats with experimental diabetes, Guerin’s carcinoma, and their combination.Materials and methods.
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. A. Sheiko, E. I. Surikova, I. V. Neskubina, I. K. Trepitaki, Yu. A. Pogorelova, N. D. Cheryarina, L. A. Nemashkalova, I. M. Kotieva, A. V. Shaposhnikov, M. I. Morozova   +12 more
doaj   +1 more source

Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Бюллетень сибирской медицины, 2022
Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy.The aim of the study was to analyze the levels of insulin-like growth factors (IGFs), their carrier proteins (
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, L. K. Trepitaki, N. D. Cheryarina, I. M. Kotieva, M. I. Morozova   +9 more
doaj   +1 more source

Indices of insulin-like growth factors family in the lung tissue of patients with non-small cell lung cancer after COVID-19 of various severity

Южно-Российский онкологический журнал, 2023
Purpose of the study. An analysis of levels of IGF and their carrying proteins in lung tissues of cancer patients depending on the severity of the previous COVID-19 infection.Patients and methods.
O. I. Kit, E. M. Frantsiyants, D. A. Kharagezov, V. A. Bandovkina, N. D. Cheryarina, Yu. A. Pogorelova, Yu. N. Lazutin, A. G. Milakin, I. A. Leyman, O. N/ Stateshny   +9 more
doaj   +1 more source

Effect of diabetes mellitus on levels of insulin-like growth factors and their carrier proteins in Guerin’s carcinoma and it’s perifocal tissue in rats

Исследования и практика в медицине, 2021
Purpose of the study. Diabetes mellitus (DM) is considered an independent risk factor for higher cancer incidence and death rates. The system of insulin-like growth factors and their carrier proteins (IGF and IGFBP) and hyperglycemia create favorable ...
E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, N. D. Cheryarina, P. S. Kachesova, L. A. Nemashkalova   +8 more
doaj   +1 more source

Associations of insulin and insulin-like growth factors with physical performance in old age in the boyd orr and caerphilly studies. [PDF]

, 2012
OBJECTIVE: Insulin and the insulin-like growth factor (IGF) system regulate growth and are involved in determining muscle mass, strength and body composition.
David Gunnell, Gunnell, David, Gallacher, John, Martin, Richard M., Birnie, K, Gunnell, D, Kate Birnie, Gunnell David, Antony Bayer, Bayer Antony, John Gallacher, Ebrahim, S, Holly, Jeff MP, Bayer, A, Yoav Ben-Shlomo, Birnie Kate, Shah Ebrahim, Ben-Shlomo, Y, Ebrahim, Shah, Jeff M P Holly, Gunnell, DJ, Gallacher, J, Martin, Richard M, Holly, JM, Bayer, Antony, Jeff M. P. Holly, Martin Richard M., Martin, RM, Richard M Martin, Richard M. Martin, Holly Jeff M. P., Gallacher John, Holly, JMP, Holly, Jeff M. P., Bayer, Antony James, Birnie, Kate, Ben-Shlomo, Yoav, Ben-Shlomo Yoav, Ebrahim Shah, Gallacher, John Edward   +39 more
core   +5 more sources

An analysis of IGFBP evolution [PDF]

Growth Hormone & IGF Research, 2008
To perform a synonymous, non-synonymous codon mutational analysis of the IGFBP gene family and identify mechanisms by which the IGFBP subfamilies diverged.We identified 78 intact nucleotide sequences from 6 IGFBP subfamilies and 12 different species and used them for phylogenetic and synonymous, non-synonymous codon mutational analysis.
Phillip V, Gordon, Marek, Marcinkiewicz
openaire   +2 more sources