Results 61 to 70 of about 45,932 (257)

Plasma IGFBP-2 levels after postoperative combined radiotherapy and chemotherapy predict prognosis in elderly glioblastoma patients.

PLoS ONE, 2014
It has been found that preoperative plasma IGFBP-2 levels correlate with prognosis in glioma patients. The prognostic value of plasma IGFBP-2 after postoperative combined radiotherapy and chemotherapy in glioma patients is unknown.
Sheng Han, Lingxuan Meng, Shuai Han, Yunjie Wang, Anhua Wu   +4 more
doaj   +1 more source

Níveis sérico de IGF-I e IGFBP-3 em pacientes admitidos por complicações da cirrose hepática [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Mestrado Profissional Associado à Residência Médica em Cuidados Intensivos e PaliativosIntrodução: IGF-I e IGFBP-3 fazem parte do sistema IGF e, por terem ...
Ronsoni, Marcelo Fernando
core  

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, Volume 13, Issue 56, 9 October 2026.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Clinicopathological correlation of insulin-like growth factor binding protein 3 and their death receptor in patients with gastric cancer

Research in Pharmaceutical Sciences
Background and purpose: The insulin-like growth factor binding protein 3 (IGFBP-3) and its novel death receptor (IGFBP-3R) have been exhibited to have tumor suppressor effects. Despite their prognostic value in some cancers, they have not been elucidated
Amir Ansari, Ali Gheysarzadeh, Ali Sharifi, Mohammad Reza Mofid   +3 more
doaj   +1 more source

Biochemical determinants of the IGFBP‐3–hyaluronan interaction

FEBS Open Bio, 2020
IGFBP‐3, the most abundant IGFBP and the main carrier of insulin‐like growth factor I (IGF‐I) in the circulation, can bind IGF‐1 with high affinity, which attenuates IGF/IGF‐IR interactions, thereby resulting in antiproliferative effects.
Sadaf Dorandish, Jonathan Devos, Bradley Clegg, Deanna Price, Robert Muterspaugh, Jeffrey Guthrie, Deborah L. Heyl, Hedeel Guy Evans   +7 more
doaj   +1 more source

Roles of IGFBP-3 in cell migration and growth in an endophytic tongue squamous cell carcinoma cell line

Scientific Reports, 2022
Insulin-like growth factor binding protein-3 (IGFBP-3) is a member of the IGFBP family that has high affinity for IGFs and functions as either an oncogene or tumor suppressor in various types of cancer.
Esther Feng Ying Ng, Atsushi Kaida, Hitomi Nojima, Masahiko Miura   +3 more
doaj   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Prediagnostic Plasma IGFBP-1, IGF-1 and Risk of Prostate Cancer

International Journal of Cancer, 2014
Insulin‐like growth factor (IGF)−1 is associated with a higher risk of prostate cancer. IGF‐binding protein (IGFBP)−1, a marker for insulin activity, also binds IGF‐1 and inhibits its action.
Yin Cao, K. Nimptsch, I. Shui, E. Platz, Kana Wu, Michael N. Pollak, S. Kenfield, M. Stampfer, E. Giovannucci   +8 more
semanticscholar   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Clinical Significance of IGFBP-3 Methylation in Patients with Early Stage Gastric Cancer

Translational Oncology, 2015
BACKGROUND: IGFBP-3 is a multifunctional protein that inhibits growth and induces apoptosis of cancer cells. Hypermethylation of the promoter represses expression of the IGFBP-3 gene. We undertook this study to assess the impact of IGFBP-3 methylation on
Seung Tae Kim, Hye-Lim Jang, Jeeyun Lee, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Min Gew Choi, Jae Moon Bae, Tae Sung Sohn, Jae Hyung Noh, Sung Kim, Kyoung-Mee Kim, Won Ki Kang, Joon Oh Park   +13 more
doaj   +1 more source