Results 71 to 80 of about 45,932 (257)

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

BMC Cancer, 2008
Background IGF binding protein-3 (IGFBP-3) regulates the bioavailability of insulin-like growth factors I and II, and has both anti-proliferative and pro-apoptotic properties.
Omofoye Oluwaseun, Proffitt Michelle, Woosley John T, Galanko Joseph, Simmons James G, Sandler Robert S, Keku Temitope O, McDoom Maya, Lund Pauline K   +8 more
doaj   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Producción de las proteínas de unión al factor de crecimiento insulinoide durante el desarrollo de la fibrosis hepática por hepatitis C crónica

Revista de Gastroenterología de México, 2020
Resumen: Introducción y objetivos: El factor de crecimiento tipo insulinoide 1 es modulado por las proteínas de unión al factor de crecimiento de tipo insulinoide (IGFBP); dichas proteínas son sintetizadas en el hígado.
D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes   +13 more
doaj   +1 more source

Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis. [PDF]

PLoS ONE, 2012
Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Ximena D Ruiz, Logan R Mlakar, Yukie Yamaguchi, Yunyun Su, Adriana T Larregina, Joseph M Pilewski, Carol A Feghali-Bostwick   +6 more
doaj   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Serum Insulin-like Growth Factor-Binding Protein-2 as a Prognostic Factor for COVID-19 Severity

Biomedicines
Insulin-like growth factor-binding protein (IGFBP)-2 is a regulator of anabolic pathways, which become inactivated in severe illness. Here, we measured the serum IGFBP-2 levels of COVID-19 patients with moderate and severe disease as well as healthy ...
Patricia Mester, Ulrich Räth, Stephan Schmid, Pablo Amend, Dennis Keller, Sabrina Krautbauer, Sofiia Bondarenko, Martina Müller, Christa Buechler, Vlad Pavel   +9 more
doaj   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

IGFBP-3 Inhibits Cytokine-Induced Insulin Resistance and Early Manifestations of Atherosclerosis

PLoS ONE, 2013
Metabolic syndrome is associated with visceral obesity, insulin resistance and an increased risk of cardiovascular diseases. Visceral fat tissue primarily consists of adipocytes that secrete cytokines leading to a state of systemic inflammation in obese ...
Lathika Mohanraj, Ho-Seong Kim, Wei Li, Q. Cai, Ki Eun Kim, Hye-Jung Shin, Yong-Jae Lee, Woo J. Lee, Jung Hyun Kim, Y. Oh   +9 more
semanticscholar   +1 more source

The utility of serum markers in the conservative management of placenta accreta spectrum (PAS) by leaving the placenta in situ in women with high‐grade PAS

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the association between serum markers and successful conservative management of patients with placenta accreta spectrum (PAS). Methods This was a retrospective case–control study where patients with high‐grade PAS between 2011 and 2025 undergoing conservative leaving the placenta in situ were included.
Ammar Al Naimi, Charlotte Wiesmann, Doerthe Brueggmann, Anna Elisabeth Hentrich, Eileen Deuster, Samira Catharina Hoock, Lukas Jennewein, Frank Louwen   +7 more
wiley   +1 more source