Results 121 to 130 of about 1,046,670 (302)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Catalase Activity of IgG and κκ-IgG, λλ-IgG, and κλ-IgG Subfractions in HIV-Infected Patients and Healthy Donors

Frontiers in Bioscience-Landmark
Background: Human immunodeficiency virus (HIV) infection is associated with pronounced oxidative stress, leading to the development of various virus-associated pathologies. A wealth of evidence suggests that, along with canonical enzymes of reactive oxygen species regulation, human blood contains antibodies with peroxidase, superoxide dismutase, and ...
Georgy A. Nevinsky, Natalya M. Gashnikova, Lada V. Maksimenko, Anna M. Timofeeva, Margarita K. Onvumere, Sergey E. Sedykh, Anna S. Tolmacheva   +6 more
openaire   +3 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Arsenic in the groundwater aquifers of the Venetian Plain: geochemical modelling and occurrence of As-sulfides minerals, a review of data from the medio Brenta domain (Italy)

Acque Sotterranee
The Venetian Plain is known for areas with high concentrations of arsenic (As) in groundwater (up to more than 400 μg/L; exceptionally 647 μg/L, in selected areas). A study area was chosen, north of Padua, which exhibits typical residential, industrial,
Fabio Tateo, Paolo Fabbri, Maria Chiara Dalconi, Luca Peruzzo   +3 more
doaj   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Pattern of IgM and IgG changes depending on the pathological process duration in patients with autoimmune thyroiditis

Zaporožskij Medicinskij Žurnal
The aim of the study was to find out the pattern of IgM and IgG changes in patients with autoimmune thyroiditis depending on the pathological process duration. Materials and methods.
R. R. Rahimova, L. Mehdiyev, G. S. Dashdamirova, S. R. Guliyeva, U. H. Azizova, F. F. Rzayeva   +5 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Seroprevalence Study of Anti-HEV IgG among Different Adult Populations in Corsica, France, 2019

Microorganisms, 2019
Hepatitis E virus (HEV) is a major cause of acute hepatitis worldwide. In France, hyperendemic areas including Corsica have an anti-HEV Immunoglobulin G (IgG) prevalence higher than 50%.
Lisandru Capai, Shirley Masse, Pierre Gallian, Cécile Souty, Christine Isnard, Thierry Blanchon, Brigitte Peres, Xavier de Lamballerie, Rémi Charrel, Alessandra Falchi   +9 more
doaj   +1 more source

Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children. [PDF]

, 2008
BACKGROUND: Antigen-specific antibody-mediated immune responses play an important role in natural protection against clinical malaria, but conflicting estimates of this association have emerged from immuno-epidemiological studies in different ...
Remarque Ed, Aikins, Anastasia, Chilengi Roma, Roma Chilengi, Kwadwo Asamoah Kusi, Aikins Anastasia, Yaa Difie Osei, Dodoo, Daniel, Lamptey, Helena, Ed Remarque, Paul Milligan, Akanmori, Bartholomew Dicky, Samuel Bosomprah, Osei Yaa Difie, Chilengi, Roma, Milligan Paul, Kusi Kwadwo, Bosomprah Samuel, Theisen, Michael, Daniel Dodoo, Milligan, Paul, Kusi, Kwadwo Asamoah, Anastasia Aikins, Remarque, Ed, Helena Lamptey, Akanmori Bartholomew, Theisen Michael, Lamptey Helena, Dodoo Daniel, Bosomprah, Samuel, Osei, Yaa Difie, Michael Theisen, Bartholomew Dicky Akanmori   +32 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source