Results 101 to 110 of about 1,066,993 (308)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Influence of Beta-lactoglobulin on the uptake and passage of IgG in the intestinal cell in vivo and in vitro

, 2002
Studies were conducted to determine the effects of the whey protein Beta-lactoglobulin (BLG) on the delivery and transport of a particular immunoglobulin, IgG.
Sutton, Leonard Franklin Jr.
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The covalent interaction of C3 with IgG immune complexes

, 1999
Antigens (Ags) are converted into immune complexes (antigen-antibody complexes, IC) as soon as they encounter their specific antibodies (Abs). In fluids containing complement, the process of IC formation and fixation of complement components occur ...
Carlos Pastor, Vivanco Martínez, Fernando, Esther Muñoz, Fernando Vivanco, Vidarte, Luis, Muñoz, Esther, Pastor Vargas, Carlos, Luis Vidarte   +7 more
core   +1 more source

A global dataset of helium isotopic data in tectonically and hydrothermally active geological environments

Scientific Data
Since the early 1970s, helium isotopes 3He and 4He have been used to trace the sources of deep-seated fluids in various geodynamic settings. Observed variations in the 3He/4He ratio measured at the surface are ascribed to source compositional variability
Fabrizio Gherardi, Gianluca Facca, Lisa Pierotti, Giovanni Martinelli, Daniele Luigi Pinti   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Kit Ujian Pantas COVID-19 IgG/IgM [PDF]

, 2020
Ramai terkeliru dengan COVID-19 IgG/ Kit Ujian Pantas IgM (Rapid Detection Kit). Ada juga yang memanggilnya vaksin. Untuk menggelakkan kekeliruan, kit tersebut bukanlah vaksin, tetapi kit bertujuan untuk mengesan kehadiran antibodi iaitu immunoglobulin (
Mohd Nasir, Mohd Hamzah
core  

Catalase Activity of IgG and κκ-IgG, λλ-IgG, and κλ-IgG Subfractions in HIV-Infected Patients and Healthy Donors

Frontiers in Bioscience-Landmark
Background: Human immunodeficiency virus (HIV) infection is associated with pronounced oxidative stress, leading to the development of various virus-associated pathologies. A wealth of evidence suggests that, along with canonical enzymes of reactive oxygen species regulation, human blood contains antibodies with peroxidase, superoxide dismutase, and ...
Georgy A. Nevinsky, Natalya M. Gashnikova, Lada V. Maksimenko, Anna M. Timofeeva, Margarita K. Onvumere, Sergey E. Sedykh, Anna S. Tolmacheva   +6 more
openaire   +3 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura

, 2009
BACKGROUND: ADAMTS13-neutralizing IgG autoantibodies are the major cause of acquired thrombotic thrombocytopenic purpura (TTP). OBJECTIVE: To analyze the IgG subclass distribution of anti-ADAMTS13 antibodies and a potential relationship between subclass ...
Rieger, M, Ferrari, S, Kremer Hovinga, J A, Veyradier, A, Scheiflinger, F, Mudde, G C, Kremer Hovinga Strebel, Johanna Anna   +6 more
core   +1 more source