Results 81 to 90 of about 990,741 (312)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients [PDF]

, 2016
Background: Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD).
Ringelstein, M., Gross, N., Ach, T., Janine Mikolajczak, Nikolai Gross (3411101), Buttmann, Mathias, Janine Mikolajczak (792945), Waldman, Amy, Friedemann Paul (25657), Markus Reindl, Thomas Ach, Paul, Friedemann, Brigitte Wildemann, Kerstin Soelberg, Schumacher, S., Orhan Aktas, Florence Pache (789593), Brandt, Alexander U, Bellmann-Strobl, Judith, Reindl, Markus, Florence Pache, Mathias Buttmann (239218), Waldman, A., Buttmann, Ma., Wildemann, B., Ruprecht, Klemens, Friedemann Paul, Kerstin Soelberg (3411095), Ringelstein, Marius, Schumacher, Sophie, null null, Amy Waldman (3411092), Oertel, F.C., Nasrin Asgari (3411086), Brandt, Alexander U., Nasrin Asgari, Anna Lacheta, Judith Bellmann-Strobl, Paul, F., Lacheta, A., Klemens Ruprecht, Sophie Schumacher (3411104), Wildemann, Brigitte, Soelberg, Kerstin, Judith Bellmann-Strobl (96062), Mikolajczak, Janine, Alexander Brandt (3411098), Reindl, M., Mathias Buttmann, Bellmann-Strobl, J., Ruprecht, K., Jarius, Sven, Sven Jarius (25658), Pache, F., Marius Ringelstein (171207), Anna Lacheta (3411107), Pache, Florence, Asgari, Nasrin, Mikolajczak, J., Oertel, Frederike C., Zimmermann, Hanna, Sophie Schumacher, Hanna Zimmermann (319981), Frederike Oertel (3411083), Aktas, Orhan, Asgari, N., Zimmermann, H., Gross, Nikolai, Alexander U. Brandt, Hanna Zimmermann, Klemens Ruprecht (187598), Thomas Ach (3411089), Aktas, O., Lacheta, Anna, Markus Reindl (89559), Nikolai Gross, Jarius, S., Marius Ringelstein, Orhan Aktas (25659), Soelberg, K., Brandt, A.U., Ach, Thomas, Sven Jarius, Amy Waldman, Frederike C. Oertel, Brigitte Wildemann (316416), Soelberg, Kerstin; id_orcid   +86 more
core   +1 more source

The Imperative of Co-existence

Technophany
In this article I examine the problem of technique in Georges Bataille's social ontology by means of a counterpoint with Bernard Stiegler's philosophy. I will defend the following theses: 1.
Tomás Ramos Mejía
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

IgG-mediated stimulation of IL-8 production by HTR8/SV.neo (trophoblastic cell line), and inhibition by pre-treatment with mouse anti-hTLR4 or by absorption on cardiolipin-Sepharose.

, 2018
IL-8 stimulation by IgG preparations was significantly greater (p < .0001) than other groups (ANOVA and TUKEY HSD). C: unstimulated control; IgG: cells treated with 20 ug/ml purified IgG; IgG-absorbed: cells treated with IgG (20 ug/ml) purified from sera
Harvey A. Schenkein (5728673), Ravindar R. Thomas (751216)   +1 more
core   +1 more source

In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart

OncoImmunology, 2021
IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies.
Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H. Josephs, Heather J. Bax, Amy E. Gilbert, Tihomir S. Dodev, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Jitesh Chauhan, Julia E. Blower, Margaret S. Cooper, James Spicer, Sophia N. Karagiannis, Philip J. Blower   +15 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Validation of a Point-of-Care Quantitative Equine IgG Turbidimetric Immunoassay and Comparison of IgG Concentrations Measured with Radial Immunodiffusion and a Point-of-Care IgG ELISA [PDF]

, 2017
BACKGROUND Point-of-care (POC) diagnostic tests with good sensitivity and specificity are needed for diagnosing failure of transfer of passive immunity (FTPI) in foals.
Fouché, Nathalie Elisa, N. Fouché, Schwarzwald, C C, Howard, Judith, Schoster, A, J. Howard, Ujvari, S, S. Ujvari, C.C. Schwarzwald, A. Schoster   +9 more
core   +1 more source

London to the south. Scenes of Argentine reading around an American author

Estudios de Teoría Literaria, 2016
The article opens with a critical review of Pierre Bourdieu’s proposal for the study of international exchanges regarding culture. After discussing the problematic aspects of his notion of “misunderstanding”, it puts forth an analysis of two argentine ...
Agustín Molina y Vedia
doaj  

Serum IgA, IgG, IgM levels, total protein (TP), albumin (ALB) changes in elderly hip fracture patients after surgery and nutritional support [PDF]

Journal of Medical Biochemistry
Background: This study aimed to evaluate the effects of nutritional support combined with stratified nursing under delirium risk assessment on immune function and postoperative delirium in elderly hip fracture patients.
Jin Fangqin, Zhang Qin, Weng Jiangping, Pan Xuting, Dong Qinyan, Zhao Yuping   +5 more
doaj   +1 more source