Results 91 to 100 of about 1,066,993 (308)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Preparation of IgG Subclass Allotypes from Polyclonal IgG [PDF]

Scandinavian Journal of Immunology, 1999
Two allotypes have been identified for each of the IgG subclasses IgG1, IgG2 and IgG3. These allotypes are referred to as G1m(a) and G1m(f), G2m(n) and G2m(‐n), and G3m(g) and G3m(b). Using a pool of normal human serum and a combination of preparative electrophoresis, DEAE ion‐exchange and protein A–Sepharose chromatography, it was possible to separate
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Supplemental material for MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response

, 2018
Supplemental material for MOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response by Lekha Pandit, Sharik Mustafa, Ichiro Nakashima, Toshyuki Takahashi and Kimhiko Kaneko in Multiple ...
Ichiro Nakashima (3574049), Toshyuki Takahashi (5531018), Kimhiko Kaneko (5531021), Sharik Mustafa (728675), Lekha Pandit (728673)   +4 more
core   +1 more source

Identification and expression of a murine cytomegalovirus early gene coding for an Fc receptor [PDF]

, 1994
Several herpesviruses, including cytomegalovirus, induce receptors for the Fc domain of murine immunoglobulin G (IgG) molecules. Viral genes coding for these receptors have been characterized only for alphaherpesviruses. In this report, we describe a new
Eggers, Maren, Thäle, Regine, Koszinowski, Ulrich H., Lucin, Pero, Schneider, Karin   +4 more
core   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Seroprevalence of Anti-Toxoplasma Gondii IgG and IgM Antibodies in Serum Samples Referred to Educational Hospitals of Abadan [PDF]

مجله دانشکده پزشکی اصفهان
Background: Toxoplasma gondii is an obligate apicomplexan parasite and it is stated that one-third of the world population are seropositive for the antibodies against the parasite.
Shahrzad Soltani, Hadi Moghaddam, Maghsoudi Fatemeh, Sanaz Tavakoli   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Earthquake dynamics sustained by seismic CO2

Nature Communications
Seismic faults paradoxically combine high frictional strength, which promotes stress accumulation and should hinder slip, with large seismic displacements.
Manuel Curzi, Andrea Billi, Luca Aldega, Ilaria Baneschi, Chiara Boschi, Antonio Caracausi, Andrea Cavallo, Giovanni Ruggieri, Eugenio Carminati   +8 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source