Results 71 to 80 of about 1,363,297 (304)

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions [PDF]

Journal of Allergy and Clinical Immunology, 2018
In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.
Epp, A., Hobusch, J., Bartsch, Y.C., Petry, J., Lilienthal, G.M., Koeleman, C.A.M., Eschweiler, S., Mobs, C., Hall, A., Morris, S.C., Braumann, D., Engellenner, C., Bitterling, J., Rahmoller, J., Leliavski, A., Thurmann, R., Collin, M., Moremen, K.W., Strait, R.T., Blanchard, V., Petersen, A., Gemoll, T., Habermann, J.K., Petersen, F., Nandy, A., Kahlert, H., Hertl, M., Wuhrer, M., Pfutzner, W., Jappe, U., Finkelman, F.D., Ehlers, M.   +31 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Estimating daily semantic segmentation maps of classified ocean eddies using sea level anomaly data from along-track altimetry

Frontiers in Artificial Intelligence
Mesoscale eddies, which are fast-moving rotating water bodies in the ocean with horizontal scales ranging from 10 km to 100 km and above, are considered to be the weather of the oceans.
Eike Bolmer, Adili Abulaitijiang, Jürgen Kusche, Ribana Roscher, Ribana Roscher   +4 more
doaj   +1 more source

The effect of Staphylococcus aureus carriage in late pregnancy on antibody levels to staphylococcal toxins in cord blood and breast milk. [PDF]

, 2008
We investigated the effect of carriage of Staphylococcus aureus in the later stages of pregnancy on levels of antibody specific to the S. aureus toxins, staphylococcal enterotoxin B (SEB), staphylococcal enterotoxin C (SEC) and toxic shock syndrome toxin-
Al Madani, Alm, Blackwell, Cui, David R. Telford, Essery, Fleming, Ford, Fujita, Gordon, Harrison, Harrison, Harrison, Holt, Hu, James A. Morris, Leach, Linda M. Harrison, Lindberg, Loch, Malam, Mathews, Molony, Morris, Morris, Murrell, Narita, Newbould, Notermans, Parsonnet, Peacock, Robert M. Lauder, Siarakas, Takahashi, Telford, Vergeront, Wilmott-Pitcher, Zorgani   +37 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Imperative of Co-existence

Technophany
In this article I examine the problem of technique in Georges Bataille's social ontology by means of a counterpoint with Bernard Stiegler's philosophy. I will defend the following theses: 1.
Tomás Ramos Mejía
doaj   +1 more source

Lactoferrin and immunoglobulin content in camel milk from bactrian, dromedary and hybrids in Kazakhstan [PDF]

, 2008
Milk of Camelidae is well-known for there health effects on human. This effect is partially attributed to their antibacterial properties. These properties could be linked to some substances, like proteins, lipids and vitamins.
Faye, Bernard, Konuspayeva, Gaukhar, Levieux, Didier, Loiseau, Gérard   +3 more
core  

The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs [PDF]

The Journal of Immunology, 2003
Abstract Abs of the IgG isotype are efficiently transported from mother to neonate and have an extended serum t1/2 compared with Abs of other isotypes. Circumstantial evidence suggests that the MHC class I-related protein, the neonatal FcR (FcRn), is the FcR responsible for both in vivo functions.
Roopenian, D C, Christianson, G J, Sproule, T J, Brown, A C, Akilesh, S, Jung, N, Petkova, S, Avanessian, L, Choi, E Y, Shaffer, D J, Eden, P A, Anderson, C L   +11 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart

OncoImmunology, 2021
IgE antibodies elicit powerful immune responses, recruiting effector cells to tumors more efficiently and with greater cytotoxicity than IgG antibodies.
Francis Man, Alexander Koers, Panagiotis Karagiannis, Debra H. Josephs, Heather J. Bax, Amy E. Gilbert, Tihomir S. Dodev, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Jitesh Chauhan, Julia E. Blower, Margaret S. Cooper, James Spicer, Sophia N. Karagiannis, Philip J. Blower   +15 more
doaj   +1 more source