Results 71 to 80 of about 1,046,670 (302)

Image_2_ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation.TIF

, 2019
Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3. Recently, a genetic variant of the Suppression of tumorigenicity 18 (ST18) promoter was reported to cause ST18 up-regulation, associated with ...
Ofer Sarig (2697442), Eli Sprecher (251645), Mariya Y. Radeva (625707), Elias Walter (4975826), Jens Waschke (103956), Nicolas Schlegel (792185), Ramona Alexandra Stach (6595340), Amir S. Yazdi (245762)   +7 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

GEOBASI: The geochemical Database of Tuscany Region (Italy)

Acque Sotterranee, 2015
In this study the new Regional Geochemical Database (RGDB), called GEOBASI, is presented and illustrated in the framework of a joint collaboration among the three Tuscan universities (Florence, Pisa and Siena), CNR-IGG (Institute of Geosciences and Earth
Brunella Raco, Antonella Buccianti, Manuela Corongiu, Guido Lavorini, Patrizia Macera, Francesco Manetti, Riccardo Mari, Giulio Masetti, Stefano Menichetti, Barbara Nisi, Giuseppe Protano, Stefano Romanelli   +11 more
doaj   +1 more source

Image_1_ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation.TIF

, 2019
Pemphigus is an autoimmune blistering disease targeting the desmosomal proteins desmoglein (Dsg) 1 and Dsg3. Recently, a genetic variant of the Suppression of tumorigenicity 18 (ST18) promoter was reported to cause ST18 up-regulation, associated with ...
Ofer Sarig (2697442), Eli Sprecher (251645), Mariya Y. Radeva (625707), Elias Walter (4975826), Jens Waschke (103956), Nicolas Schlegel (792185), Ramona Alexandra Stach (6595340), Amir S. Yazdi (245762)   +7 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Geochemical particularities of microbioliths of the Miocene (South-Western Crimea) by ICP-MS data

Литосфера, 2019
Background. In this paper, we provide new data on the morphology and geochemistry of heraclites, which are represented by specific products formed by degradation of the carbonate paleostructures of prokaryotes around the degassing zones of the Miocene ...
O. B. Azovskova, T. V. Mikhailichenko
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Estimating daily semantic segmentation maps of classified ocean eddies using sea level anomaly data from along-track altimetry

Frontiers in Artificial Intelligence
Mesoscale eddies, which are fast-moving rotating water bodies in the ocean with horizontal scales ranging from 10 km to 100 km and above, are considered to be the weather of the oceans.
Eike Bolmer, Adili Abulaitijiang, Jürgen Kusche, Ribana Roscher, Ribana Roscher   +4 more
doaj   +1 more source