Results 291 to 300 of about 1,067,036 (373)

NaBC1 Boron Transporter Enables Myoblast Response to Substrate Rigidity via Fibronectin‐Binding Integrins

open access: yesAdvanced Science, EarlyView.
Cells transduce the rigidity of the environment into biochemical cues through mechanotransductive cascades that modulate cell behavior. Here, a novel role for the boron transporter NaBC1 is identified as a mechanotransducer involved in regulating cell behavior via specific crosstalk with fibronectin‐binding integrins.
Juan Gonzalez‐Valdivieso   +9 more
wiley   +1 more source

Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study reveals that KMT5C activates DNA damage repair to inhibit STING‐IRF3 pathway, downstream type I IFN signaling and CCL5 secretion, leading to the downregulation of CD8+ T cell infiltration and function in NSCLC, ultimately facilitating tumor progression.
Yunfeng Yuan   +11 more
wiley   +1 more source

The Prevalence of Toxoplasmosis in Bulgaria for the Period 2014-2023, with a Focus on Pregnant Women. [PDF]

open access: yesPathogens
Rainova I   +6 more
europepmc   +1 more source

Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection

open access: yesAdvanced Science, EarlyView.
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen   +8 more
wiley   +1 more source

Rubella seroprevalence among women of childbearing age in Tunis, Tunisia. [PDF]

open access: yesBMC Infect Dis
Ben Moussa ML   +3 more
europepmc   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

open access: yesAdvanced Science, EarlyView.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He   +6 more
wiley   +1 more source

Intravitreal delivery of NMO-IgG causes primary retinal damage in the absence of optic nerve injury. [PDF]

open access: yesJ Neuroinflammation
Chen B   +12 more
europepmc   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

open access: yesAdvanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi   +7 more
wiley   +1 more source

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