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We studied IgG subclass distribution of ANCA in 247 patients with ELISA. We used monoclonal subclass specific antibodies and purified MPO and proteinase 3 as antigen. We found that IgG1 and IgG4 yield high values in both groups. We also found that high IgG2 titers were rare among the anti-proteinase 3 positive, while it was common among anti-MPO sera ...
Mårten Segelmark, Jörgen Wieslander
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Oligoclonal IgG in tears [PDF]
We examined tears from patients with MS and systemic or eye diseases, and normal controls. Tears were isoelectrofocused on agarose gel, silver-stained, and immunofixated for IgG. In the cathodal portion of the gel (pH greater than or equal to 8.3), oligoclonal bands were detected in 14 of 21 (67%) MS tear samples.
Cynthia Johnson+2 more
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Quantitation of human total IgG, kappa IgG and lambda IgG in serum using monoclonal antibodies
Journal of Immunological Methods, 1980Monoclonal antibodies to human IgG have been applied, in parallel with polyclonal antisera, to the routine quantitation of human IgG. Two monoclonal antibodies directed against spatially distinct epitopes have been used in combination to form insoluble complexes exhibiting turbidity.
W.G. Reeves+3 more
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Annual Review of Medicine, 1987
IgG subclasses represent distinct immunoglobulin types, each defined by unique primary structures of the constant region of the heavy-chain molecule, and each with characteristic biological and functional properties. New methods and reagents to measure serum concentrations have contributed to the study of the ontogeny, antigen restriction, and ...
R J Wedgwood, H D Ochs
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IgG subclasses represent distinct immunoglobulin types, each defined by unique primary structures of the constant region of the heavy-chain molecule, and each with characteristic biological and functional properties. New methods and reagents to measure serum concentrations have contributed to the study of the ontogeny, antigen restriction, and ...
R J Wedgwood, H D Ochs
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Expanded phenotypes and outcomes among 256 LGI1/CASPR2‐IgG–positive patients
Annals of Neurology, 2017To describe an expanded phenotypic spectrum and longitudinal outcome in 256 LGI1‐IgG–seropositive and/or CASPR2‐IgG–seropositive patients.
A. Gadoth+12 more
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The American Journal of Dermatopathology, 2014
IgG/IgA pemphigus has recently been described in the literature as an overlap of pemphigus vulgaris or pemphigus foliaceus with IgA pemphigus. There has also been some postulation that this IgG/IgA pemphigus may be associated with internal malignancy as well.
Palak Parekh, Natalie Lane
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IgG/IgA pemphigus has recently been described in the literature as an overlap of pemphigus vulgaris or pemphigus foliaceus with IgA pemphigus. There has also been some postulation that this IgG/IgA pemphigus may be associated with internal malignancy as well.
Palak Parekh, Natalie Lane
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PROTEOMICS, 2009
AbstractA multitude of monoclonal IgG antibodies directed against a variety of therapeutic targets is currently being developed and produced by biotechnological companies. The biological activity of IgGs is modulated by the N‐glycans attached to the fragment crystallizable (Fc) part.
André M. Deelder+4 more
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AbstractA multitude of monoclonal IgG antibodies directed against a variety of therapeutic targets is currently being developed and produced by biotechnological companies. The biological activity of IgGs is modulated by the N‐glycans attached to the fragment crystallizable (Fc) part.
André M. Deelder+4 more
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Current Opinion in Neurology, 2019
PURPOSE OF REVIEW To review the clinical characteristics, radiological manifestations and treatment of myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) optic neuritis. RECENT FINDINGS Serum antibodies to MOG (MOG-IgG) have recently been
John J. Chen, M. T. Bhatti
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PURPOSE OF REVIEW To review the clinical characteristics, radiological manifestations and treatment of myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) optic neuritis. RECENT FINDINGS Serum antibodies to MOG (MOG-IgG) have recently been
John J. Chen, M. T. Bhatti
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Molecular Immunology, 1974
Abstract Citraconic anhydride and ϵ-Amino hexanoic acid were reacted and ϵ,N-Citraconyl Aminocaproate (ENCTC) was prepared. The molar extinction coefficient of ENCTC at 280 nm = 116 M −1 , and at 241 nm = 7610 M −1 . These were used to determine the number of citraconyl groups covalently attached per mole of rabbit IgG. It was found that all free
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Abstract Citraconic anhydride and ϵ-Amino hexanoic acid were reacted and ϵ,N-Citraconyl Aminocaproate (ENCTC) was prepared. The molar extinction coefficient of ENCTC at 280 nm = 116 M −1 , and at 241 nm = 7610 M −1 . These were used to determine the number of citraconyl groups covalently attached per mole of rabbit IgG. It was found that all free
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Electrophoretic heterogeneity of IgG
Clinica Chimica Acta, 1968Abstract Electrophoretic heterogeneity of IgG populations with a mobility slower than β1 has been studied by analysing the quantitative immunoelectrophoresis patterns. The populations studied were arbitrarily subdivided in 3 ranges, slow (S), medium (M) and fast (F).
E. Afonso, J.S. Proenca
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