Results 181 to 190 of about 1,581,690 (305)

Clinical implications of imlifidase interference in antibody screening and transfusion management

Transfusion, EarlyView.
Abstract Background Imlifidase has received conditional approval from the EMA for desensitizing deceased donor kidney transplant recipients. It works by cleaving IgG into F(ab′)2 and Fc fragments, thereby reducing the risk of antibody‐mediated rejection. However, its impact on diagnostic assays remains understudied. Case Report We present the case of a
Zgjim Osmani, Aiko P. J. de Vries, Arjan Albersen   +2 more
wiley   +1 more source

Immunosuppressants for IgG4-related disease. [PDF]

Cochrane Database Syst Rev
Cagnotto G, Bäcklund RT, Bengtsson A, Bruschettini M, supported by Cochrane Sweden.   +4 more
europepmc   +1 more source

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): A Comprehensive Review of Types, Pathophysiology, and Treatment Approaches

Brain and Behavior, Volume 16, Issue 5, May 2026.
Chronic inflammatory demyelinating polyneuropathy is an autoimmune disorder causing demyelination, leading to distal weakness, sensory loss, and autonomic dysfunction. Immune activation triggers macrophage‐mediated myelin damage and conduction failure.
Ayesha Khan, Arsal Khan, Kuldeep Dalpat Rai, Anzel Saeed, Harsh Kumar, Aneesh Kumar Sangtiani, Tehreem Fatima, Muhammad Tanveer Alam, Faiza Rajput, Sakshi Chawla, Hussain Haider Shah, Humaira Kalam   +11 more
wiley   +1 more source

Integration Analysis of Bayesian and Machine Learning for Heterogeneity, Biomarkers, and Optimal Combination Regimens of Pucotenlimab in Solid Tumors

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT The efficacy of PD‐1 inhibitor pucotenlimab (HX008) in solid tumors exhibits heterogeneity. This study integrated data from 6 clinical trials (covering gastric/gastroesophageal junction cancer, triple‐negative breast cancer, melanoma, and dMMR/MSI‐H solid tumors) using Bayesian meta‐analysis, machine learning (optimal XGBoost AUC = 0.86), and ...
Yingge He, Changqing Gao, Shiyan Zhang, Yonghui Hao, Shuning He, Ke Peng, Liqi Li   +6 more
wiley   +1 more source

Molecular Structures and Molecular Interactions of Peptides and Proteins at Buried Interfaces Studied Using Sum Frequency Generation Vibrational Spectroscopy

Chemistry–Methods, Volume 6, Issue 5, May 2026.
This review provides a detailed record of recent advances in the field of determining protein conformation and orientation on various interfaces using sum frequency generation vibrational spectroscopy. We delve deep into how the addition of the Hamiltonian spectral matching formalism, isotope labeling, and Molecular Dynamics simulations has allowed us ...
Zahra Asif Gandhi, Kapil Shrawankar, Zhan Chen   +2 more
wiley   +1 more source

A Case of IgG4-Related Disease That Mimics an Anterior Mediastinal Malignant Tumour. [PDF]

Respirol Case Rep
Nishimura N, Nakamura Y, Yazawa N, Goto Y, Suzuki T, Inoue T, Hasegawa A, Ikeda K, Takemasa A, Chida M, Ishida K, Shimizu Y, Niho S.   +12 more
europepmc   +1 more source

IgG4‐Related Disease: Clinical and Laboratory Features in One Hundred Twenty‐Five Patients

Arthritis & Rheumatology, 2015
Z. Wallace, V. Deshpande, H. Mattoo, V. Mahajan, M. Kulikova, S. Pillai, J. Stone   +6 more
semanticscholar   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Coexistence of SAPHO syndrome and IgG4-related disease with Upadacitinib. [PDF]

Clin Transl Immunology
Zhou H, Zhao X, Chen R, Wang T, Zhuang Y, Liu Y.   +5 more
europepmc   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source