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Best Practice & Research Clinical Rheumatology, 2012
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a fascinating condition recognised as a systemic disease in 2003 [1,2]. The first link between autoimmunity affecting the pancreas, elevated serum IgG4 concentrations and large numbers of IgG4-positive plasma cells in pancreatic tissue was described only 2 years earlier [3].
Monica, Guma, Gary S, Firestein
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Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a fascinating condition recognised as a systemic disease in 2003 [1,2]. The first link between autoimmunity affecting the pancreas, elevated serum IgG4 concentrations and large numbers of IgG4-positive plasma cells in pancreatic tissue was described only 2 years earlier [3].
Monica, Guma, Gary S, Firestein
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IgG4-related disease of the breast
Arkhiv patologii, 2022IgG4-related disease is an immune-mediated disorder with tumor-like multiorgan involvement, elevated serum IgG4 level and specific histopathological appearance (lymphoplasmacytic infiltrate rich in IgG4+ plasma cells and storiform fibrosis). The article presents rare clinical and morphological observations of IgG4-related mastopathy in women with ...
M.G. Rybakova +2 more
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Management of IgG4-related disease
The Lancet Rheumatology, 2019IgG4-related disease was unrecognised as a unified disease entity until this century, yet in a short period of time the disease has been appreciated to have a worldwide distribution, and its clinical, pathological, and radiological features have been described in considerable detail.
Wen, Zhang, John H, Stone
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British Journal of Dermatology, 2014
IgG4-related disease (IgG4-RD) is a recently established clinical entity characterized by high levels of circulating IgG4, and tissue infiltration of IgG4(+) plasma cells. IgG4-RD exhibits a distinctive fibroinflammatory change involving multiple organs, such as the pancreas and salivary and lacrimal glands. The skin lesions of IgG4-RD have been poorly
Y, Tokura +7 more
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IgG4-related disease (IgG4-RD) is a recently established clinical entity characterized by high levels of circulating IgG4, and tissue infiltration of IgG4(+) plasma cells. IgG4-RD exhibits a distinctive fibroinflammatory change involving multiple organs, such as the pancreas and salivary and lacrimal glands. The skin lesions of IgG4-RD have been poorly
Y, Tokura +7 more
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Scleroderma and IgG4-Related Disease
The American Journal of Dermatopathology, 2013IgG4-related disease is a syndrome which involves lymphoplasmacytic infiltrates and soft tissue sclerosis, elevated serum IgG4 titer, and increased IgG4-positive plasma cells in a variety of tissues. Scleroderma is also characterized by fibrosis and lymphoplasmacytic infiltrates.
Deepti M, Reddi +3 more
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Pathogenesis of IgG4-related disease
Current Opinion in Rheumatology, 2011To review studies that have examined underlying genetic and immunological aspects of IgG4-related disease.Genetic studies have suggested that several human leukocyte antigen (HLA) and non-HLA haplotypes/genotypes are associated with susceptibility to IgG4-related disease or to disease relapse after steroid therapy.
Yoh, Zen, Yasuni, Nakanuma
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Archivos de la Sociedad Española de Oftalmología (English Edition), 2018
The case is presented of a 64-year-old woman with bilateral palpebral swelling and dacryoadenitis, exophthalmos, and a history of chronic rhinitis and asthma. An increase in serum IgG4 was observed, and an incisional biopsy of lacrimal glands was performed, which showed fibrosis and a lymphoplasmacytic infiltrate with IgG4 producing cells.Orbital ...
J, Flores Balverdi +5 more
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The case is presented of a 64-year-old woman with bilateral palpebral swelling and dacryoadenitis, exophthalmos, and a history of chronic rhinitis and asthma. An increase in serum IgG4 was observed, and an incisional biopsy of lacrimal glands was performed, which showed fibrosis and a lymphoplasmacytic infiltrate with IgG4 producing cells.Orbital ...
J, Flores Balverdi +5 more
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IgG4-related Disease and the Liver
Gastroenterology Clinics of North America, 2017Pathologists are likely to encounter IgG4-related disease in several organ systems. This article focuses on helping pathologists diagnose IgG4-related disease in the hepatobiliary system. Missing the diagnosis can result in unnecessary organ damage and/or unnecessary surgical and cancer therapy.
Jonathan H, Chen, Vikram, Deshpande
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2016
IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition characterized by fibrous swelling of affected organs, elevated serum IgG4 concentration in the majority of patients, and a prompt response to corticosteroid therapy. The concept of IgG4-RD as a novel clinical entity emerged at the beginning of the twenty-first century, when Hamano and ...
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IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition characterized by fibrous swelling of affected organs, elevated serum IgG4 concentration in the majority of patients, and a prompt response to corticosteroid therapy. The concept of IgG4-RD as a novel clinical entity emerged at the beginning of the twenty-first century, when Hamano and ...
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The Histopathology of IgG4-Related Disease
2016IgG4-related disease is a multi-organ immune-mediated chronic fibroinflammatory condition characterized by elevated serum IgG4 concentrations, tumefaction, and tissue infiltration by IgG4-positive plasma cells. The exact etiology of IgG4-related disease remains unclear with no known role of the IgG4 molecule itself being identified.
Mehmet Ozgur, Avincsal, Yoh, Zen
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