Results 51 to 60 of about 13,032,569 (265)

IgG4-related disease of the lung: a rare differential diagnosis to lung cancer after positive positron emission tomography and biopsy. [PDF]

, 2017
Immunoglobulin G4-related disease is a rare immune-mediated condition that often causes serious diagnostic problems. Symptoms are unspecific, and several organs can be involved.
Schmid, Ralph, Zehnder, Adrian, Gregor J Kocher, Seitz, Michael, Adrian Zehnder, Ralph A Schmid, Michael Seitz, Kocher, Gregor   +7 more
core   +2 more sources

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by immune dysregulation and fibrosis. We investigated whether abatacept modulates CD319/SLAMF7‐expressing cytotoxic T cells implicated in diffuse cutaneous SSc. Methods In this ancillary ASSET trial analysis, peripheral blood mononuclear cells from 67 participants were analyzed at baseline and months ...
Mikel Gurrea‐Rubio, Laura A. Cooney, Kohei Maeda, Phillip L. Campbell, Qi Wu, Camila I. Amarista, Alexander Stinson, Ray Ohara, Yang Mao‐Draayer, Michael L. Whitfield, Shiv Pillai, Poulami Dey, Johann E. Gudjonsson, Pei‐Suen Tsou, Dinesh Khanna, David A. Fox   +15 more
wiley   +1 more source

Case Report: A case of primary IgG4-related skin disease presenting initially with skin papules and abscesses

Frontiers in Immunology
BackgroundImmunoglobulin G (IgG) type 4-related disease (IgG4-RD) is a rare, chronic fibroinflammatory condition that can affect multiple organ systems. Cutaneous involvement in IgG4-RD is even rarer. Moreover, the clinical manifestations of primary IgG4-
Xing-Yue Chen, Jun Chen, Lei Lv, Da-Wei Jiang, Kun-Lan Long, Li-Jia Zhi   +5 more
doaj   +1 more source

Serial Salivary Gland Ultrasound Monitoring of Treatment Efficacy in IgG4-RD: A Case Report

Journal of Clinical Rheumatology and Immunology
IgG4-related disease (IgG4-RD) is a rare, multisystem, fibroinflammatory disorder with characteristic histopathology. Ongoing research continues to define optimal disease evaluation and management.
Amy Trang, Jennifer K. King, Howard H. Yang   +2 more
doaj   +1 more source

The spectrum of IgG4-related diseases

Romanian Journal of Medical Practice, 2018
IgG4-related disease (IgG4-RD) is now recognized as a worldwide disease. It is a rare systemic fibroinflammatory disorder. The evaluation for IgG4-RD should include a comprehensive clinical history, physical examination, and selected laboratory investigation, along with appropriate radiologic studies. A wide variety of organs can be involved in IgG4-RD.
Inimioara Mihaela Cojocaru, Manole Cojocaru   +1 more
openaire   +2 more sources

IgG4-related disease in patients with newly diagnosed idiopathic retroperitoneal fibrosis: a population-based Danish study

, 2019
Objectives: IgG4-related disease (IgG4-RD) may present as ‘idiopathic’ retroperitoneal fibrosis (IRPF). We aimed to determine the occurrence of IgG4-retroperitoneal fibrosis (IgG4-RPF) in a nationwide study on patients with newly diagnosed IRPF, and to ...
N Lomborg (6531722), CS Bode (6531728), M Jakobsen (6531725), P Junker (3104853)   +3 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

IGG4-related diseases in endocrinology

Problems of Endocrinology, 2020
Immunoglobulin-G4-related disease (IgG4-RD) is a chronic immunomediated pathology of different organs of local or systemic nature, which has been established as a separate clinical entity in the early 2000s and is characterized by storiform fibroid inflammation of the affected tissues, their increase, and elevated serum immunoglobulin-G4 (IgG4) levels.
Pavel O. Rumyantsev, Ivan G. Kozlov, Evgenia A. Kolpakova, Olga S. Chukhacheva, Sergey V. Korenev, Andrei G. Goncharov, Elena U. Ulanova   +6 more
openaire   +3 more sources

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source