Results 121 to 130 of about 10,698,899 (242)

Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy

Allergy, EarlyView.
In this Phase 2a trial, severely peanut‐allergic participants were randomized to abatacept versus placebo with peanut oral immunotherapy (OIT) for 24 weeks, followed by 12 weeks of OIT alone. No significant difference was observed for the primary efficacy outcome (the relative change from baseline in peanut‐specific/total IgE ratio at 24 weeks), but ...
Marie‐Lee Simard, Camille Braun, Éloise Antony, Émilie Roy, Marie‐Ève Gingras, François Graham, Anne Des Roches, Louis Paradis, Kathryn Samaan, Florence Gingras‐Lessard, Roxane Labrosse, Thomas Eiwegger, Philippe Bégin   +12 more
wiley   +1 more source

Membranous nephropathy associated with IgG4-related disease

, 2011
Immunoglobulin G4 (IgG4)-related systemic disease is a rare condition characterized by high levels of circulating IgG4 and IgG4-positive plasma cell infiltrates in various organs, including the pancreas, salivary glands, biliary tract, liver, lung, and ...
M. Abbate, M. Galbusera, Ariela Benigni, E. Sabadini, D. J. Salant, Miriam Galbusera, Giuseppe Remuzzi, G. Remuzzi, M. Maras, S. Buelli, Elena Gagliardini, David J. Salant, Laurence H. Beck, V. D'Agati, Ettore Sabadini, Paolo Cravedi, P. Cravedi, A. Benigni, Mauro Abbate, Maddalena Marasà, B. J. Laurence H., Simona Buelli, E. Gagliardini, Vivette D'Agati   +23 more
core   +1 more source

A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors

Acta Paediatrica, EarlyView.
ABSTRACT Aims Paediatric cancer survivors often experience treatment‐induced immunosuppression, requiring post‐treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute‐lymphoblastic‐leukaemia (ALL), may not be applicable across all ...
Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J. Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein   +17 more
wiley   +1 more source

A tumor of IgG4-related skin disease on a forehead with relapse 3 years after resection

JAAD Case Reports, 2021
Toshifumi Akazawa, MD, Mitsuru Sekido, MD, Koji Adachi, MD, Yukiko Aihara, MD, Risa Myojo, MD   +4 more
doaj   +1 more source

[Clinical characteristics of central nervous system involvement in IgG4 related diseases]. [PDF]

Beijing Da Xue Xue Bao Yi Xue Ban, 2021
Meng GY, Zhang YX, Zhang YX, Liu YY.
europepmc   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Role of Th2 Cells in IgG4-Related Lacrimal Gland Enlargement

, 2010
<i>Background:</i> Lacrimal gland enlargement (LGE) is one of the characteristics of Mikulicz’s disease (MD). Recently, marked serum IgG4 elevation and infiltration of IgG4-positive plasmacytes in the enlarged exocrine glands have been ...
Kotaro Suzuki, Shin-ichiro Kagami, Shunsuke Furuta, Yoshihiro Oya, Kei Ikeda, Yoshitaka Okamoto, Hiroko Kanari, Itsuo Iwamoto, Norihiko Watanabe, Hiroshi Nakajima, Koichi Hirose, Akira Suto, Daisuke Kashiwakuma, Shuichi Yamamoto   +13 more
core   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

IgG4-related pleuritis diagnosed by local anesthesia thoracoscopy; a case report and literature review

Respiratory Medicine Case Reports
IgG4-related pleuritis is rare in patients with IgG4-related diseases (IgG4RD). We report a case of IgG4-related pleuritis diagnosed in a 77-year-old Japanese man with right pleural effusion. The pleural effusion exhibited lymphocyte-predominant exudates
Genki Inui, Tomoya Harada, Karen Makishima, Aditya Sri Listyoko, Shunsuke Ohga, Miyu Nishigami, Hiroyuki Tanaka, Hiroki Ishikawa, Hiroki Kohno, Yoshihiro Funaki, Miki Takata, Ryota Okazaki, Masato Morita, Masahiro Kodani, Akira Yamasaki   +14 more
doaj   +1 more source

Periorbital presentation of IgG4 related disease

, 2018
IgG4-Related Disease is an immunomediated condition that is characterized by the presence of inflammatory lesions associated with fibrosis and lymphoplasmacytic infiltration rich in positive IgG4 tissue plasmocytes, forming a spectrum of ...
Gabriela Caroline Monteiro de Albuquerque (5911541), Rinalva Tenório Vaz (5911550), Bruna Dantas Aires Guimarães (5911544), Maria Amélia Silva de Sousa Ribeiro (5911547), Jerrar Janedson Xavier Silva (5911553)   +4 more
core   +1 more source