Results 41 to 50 of about 2,547 (124)

Diagnostic Utility of Liver Biopsy in Persistent Unexplained Liver Enzyme Elevation: A Retrospective Cohort Study

JGH Open, Volume 9, Issue 11, November 2025.
ABSTRACT Background and Aims Chronically elevated liver enzymes without a clear etiology remain a frequent diagnostic challenge. This study evaluated the diagnostic yield of liver biopsy in such cases and assessed if laboratory parameters predict histological clarification. Methods We retrospectively analyzed 71 patients with unexplained elevated liver
S. Jaawan, A. Krämer, R. Masri, A. Neesse, V. Ellenrieder, A. Amanzada, P. Ströbel, F. Bremmer, G. Petzold   +8 more
wiley   +1 more source

Endoscopic Diagnostics for IgG4-Related Pancreatobiliary Diseases: Current Modalities and Clinical Perspectives

Diagnostics
Type 1 autoimmune pancreatitis (AIP), IgG4-related sclerosing cholangitis (IgG4-SC), and IgG4-related cholecystitis are recognized as IgG4-related pancreatobiliary diseases.
Itaru Naitoh, Michihiro Yoshida, Takahiro Nakazawa   +2 more
doaj   +1 more source

Tepotinib‐Induced Cholangitis in a Patient With Non‐Small Cell Lung Cancer: A Case Report

Respirology Case Reports, Volume 13, Issue 11, November 2025.
Here, we report the first case of tepotinib‐induced cholangitis. When using MET inhibitors for chemotherapy, attention should be paid not only to treatment effectiveness but also to possible hepatobiliary side effects. ABSTRACT Tepotinib, a mesenchymal epithelial transition factor (MET) tyrosine kinase inhibitor, is used to treat non‐small cell lung ...
Yoshimasa Hachisu, Kojiro Yoshida, Yuki Hosino, Kenta Ito, Shogo Uno, Kazuma Ezawa, Hirotaka Arai, Takeo Horie   +7 more
wiley   +1 more source

European Consensus Recommendations for Direct Cholangioscopy and Pancreatoscopy Using a Modified Delphi Process

United European Gastroenterology Journal, Volume 13, Issue 9, Page 1652-1667, November 2025.
ABSTRACT Background and Aim Direct cholangioscopy and pancreatoscopy have become widely implemented techniques in the diagnostic and therapeutic algorithms of several pancreaticobiliary disorders. This study aimed to generate general and indication‐specific European consensus recommendations on cholangioscopy and pancreatoscopy.
Enrico Palmeri, Sebastian Stefanovic, Emine Gökce, Velio Ascenti, Andrea Anderloni, Vincenzo Cennamo, Frédéric Prat, George Webster, Deepak Joshi, Jonathan Potts, Terence Wong, Kofi Oppong, Martin James, Matthew Huggett, Jim Portal, Pieter Jan de Jonge, Mark Ellrichmann, Juan J. Vila, Ignacio Fernandez‐Urien, Marianne Udd, Leena Kylänpää, Wim Laleman, Jan Werner Poley, Petko Karagyozov, Frans van der Heide, Jan J. Koornstra, Emad S. Aljahdli, Christian Gerges, Rogier P. Voermans, George Goodchild, Akin Inderson, Stefano Francesco Crinó, Marco J. Bruno, David M. de Jong, Pieter Hindryckx   +34 more
wiley   +1 more source

Role of Peroral Cholangioscopy in the Diagnosis of Primary Sclerosing Cholangitis

Diagnostics, 2020
Primary sclerosing cholangitis (PSC) is characterized by idiopathic biliary stricture followed by progressive cholestasis and fibrosis. When diagnosing PSC, its differentiation from other types of sclerosing cholangitis and cholangiocarcinoma is ...
Toshio Fujisawa, Mako Ushio, Sho Takahashi, Wataru Yamagata, Yusuke Takasaki, Akinori Suzuki, Yoshihiro Okawa, Kazushige Ochiai, Ko Tomishima, Shigeto Ishii, Hiroaki Saito, Hiroyuki Isayama   +11 more
doaj   +1 more source

IgG4-Producing MALT Lymphoma in the Renal Hilum

Case Reports in Oncology, 2019
IgG4-related disease is diagnosed when both the elevation of the serum IgG4 level and invasion of IgG4-positive interstitial cells and sclerosis to a tumor are noted. Some cases have demonstrated malignant disease.
Kota Shimokihara, Takashi Kawahara, Ryo Kasahara, Jun Kasuga, Shinpei Sugiura, Ryosuke Tajiri, Hiroji Uemura, Kimio Chiba   +7 more
doaj   +1 more source

Immunoglobulin G4-related Disease: A Series of Four Cases [PDF]

Journal of Clinical and Diagnostic Research
Immunoglobulin G4-related Disease (IgG4-RD) is an immune-mediated fibroinflammatory disease that affects multiple organs, resulting in tumefactive lesions and/or organ dysfunction.
Chandni Thomas, S Divya, Joy Augustine
doaj   +1 more source

IgG4‐Related Disease: Emerging Roles of Novel Genetic Variants, Immune Cell Subsets and Therapeutic Targets

Allergy, Volume 80, Issue 10, Page 2738-2754, October 2025.
ABSTRACT IgG4, the least abundant IgG subclass in humans, is increasingly recognised for its involvement in allergic and autoimmune pathologies. Its unique properties, such as the tendency to form half‐molecules (one heavy chain and one light chain) and its generally non‐inflammatory nature, distinguish it from other IgG subclasses.
Louisa Tedesco, Syed B. Ali, Baran Erman, Safa Baris, Harshita Pant, Pravin Hissaria, Yelda Bilginer, Damon J. Tumes, Gökhan Cildir   +8 more
wiley   +1 more source

The pancreatic and extrapancreatic manifestations of IgG4-related disease

Diagnostic and Interventional Radiology, 2018
The association between immunoglobulin IgG4 and autoimmune pancreatitis was first shown in 2001. Since then many previously established fibrosclerotic diseases demonstrating synchronous or metachronous multiorgan involvement have been included within the
Jaspreet Singh Sangha Brar, Saurav Gupta, Salahudeen M. Haja Mohideen, Lishya Liauw, Narayan Lath   +4 more
doaj   +1 more source

Malignancies and IgG4‐related disease

Rheumatology &Autoimmunity, Volume 5, Issue 3, Page 161-173, September 2025.
Immunoglobulin G4‐related disease (IgG4‐RD) is associated with increased cancer risk. Malignancies affect both IgG4‐RD involved organs, such as the lung, pancreas, bile duct, and prostate, and noninvolved organs, such as the gastrointestinal duct. B‐cell neoplasms constitute a proportion of the malignancies linked to this disease.
Jingna Li, Wen Zhang
wiley   +1 more source