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Histopathology, Volume 89, Issue 1, Page 47-57, July 2026.We report a series of 12 patients (mean age 63 years) with chronic oesophageal ulceration showing morphological features of IgG4‐related inflammatory disease. Most patients underwent several rounds of endoscopy until this association was recognized. The majority of patients went into clinical and histological remission following corticosteroid therapy.
Hanna Henzinger +5 more
wiley +1 more source
Primary sclerosing cholangitis: a pre-malignant condition [PDF]
, 2017 Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease with no known cure. It is a serious condition, and diagnosis comes with an increased risk of developing cancer of the gallbladder, bile ducts or liver.
Gerri Mortimore, Mortimore, Gerri
core +1 more source
, 2017 In 2011, chronic fibroinflammatory processes occurring simultaneously or metachronously in various organs and associated with elevated IgG4 serum levels and/or tissue infiltration with IgG4-positive plasma cells have been recognized as manifestations of ...
Sönke Detlefsen +3 more
core +2 more sources
The Role of B Cells and B Cell Therapies in Immune-Mediated Liver Diseases
Frontiers in Immunology, 2021 B cells form a branch of the adaptive immune system, essential for the body’s immune defense against pathogens. B cell dysfunction has been implicated in the pathogenesis of immune mediated liver diseases including autoimmune hepatitis, IgG4-related ...
Tamsin Cargill, Emma L. Culver
doaj +1 more source
JCC Plus, Volume 1, Issue 3, May 2026.ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique clinical syndrome affecting up to 80% of PSC patients, characterised by distinct epidemiological patterns, pathophysiological mechanisms and clinical outcomes that differ substantially from either condition occurring independently ...
Luisa Bertin +7 more
wiley +1 more source
Case Reports in GastroenterologyImmunoglobulin G4-sclerosing cholangitis (IgG4-SC) is a rare fibroinflammatory disease that involves the biliary duct and can often mimic Primary Sclerosing Cholangitis (PSC).
Thomas Beyerle +4 more
doaj +1 more source
Endoscopy International Open, 2019 Background Patients with IgG4-related sclerosing cholangitis and autoimmune pancreatitis frequently develop obstructive jaundice, which requires endoscopic biliary stenting (EBS) during steroid therapy to prevent bile duct infection from cholestasis and ...
Yasuhiro Kuraishi +8 more
doaj +1 more source
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT A 49‐year‐old male developed liver dysfunction during chemotherapy for rectal cancer located in the rectosigmoid region. Although magnetic resonance cholangiopancreatography initially indicated sclerosing cholangitis, endoscopic retrograde cholangiopancreatography and intraductal ultrasonography revealed multiple non‐contiguous intraductal ...
Shinji Monoe +5 more
wiley +1 more source
DiagnosticsType 1 autoimmune pancreatitis (AIP), IgG4-related sclerosing cholangitis (IgG4-SC), and IgG4-related cholecystitis are recognized as IgG4-related pancreatobiliary diseases.
Itaru Naitoh +2 more
doaj +1 more source
Advances in Diagnosis and Treatment With Cholangiopancreatoscopy
Digestive Endoscopy, Volume 38, Issue 4, April 2026.ABSTRACT Endoscopic retrograde cholangiopancreatography (ERCP) remains the standard for diagnosing and treating pancreatobiliary diseases. Although non‐invasive imaging modalities have significantly improved, ERCP continues to play an indispensable role in clinical practice. However, ERCP has inherent limitations. Diagnostic challenges persist in cases
Takeshi Ogura +2 more
wiley +1 more source