Results 211 to 220 of about 235,216 (254)
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IgM in Cytomegalovirus Mononucleosis
Scandinavian Journal of Infectious Diseases, 1971AbstractA marked, rapid rise in the IgM concentration was found in 2 cases of cytomegalovirus mononucleosis. These patients showed signs of liver involvement with a moderate increase in SGOT and SGPT and elevation of the thymol values. A third patient with normal transaminase and thymol values had no IgM changes.
F, Nordbring, S G, Johansson
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Current Opinion in Rheumatology, 2003
The immune defense against extracellular pathogens is largely dependent on antibody production. Class switch recombination and somatic hypermutation shape the secondary antibody repertoire in peripheral lymphoid tissue. In the past few years, a series of primary immune deficiencies characterized by defects in these processes and collectively referred ...
GULINO AV, NOTARANGELO, Luigi Daniele
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The immune defense against extracellular pathogens is largely dependent on antibody production. Class switch recombination and somatic hypermutation shape the secondary antibody repertoire in peripheral lymphoid tissue. In the past few years, a series of primary immune deficiencies characterized by defects in these processes and collectively referred ...
GULINO AV, NOTARANGELO, Luigi Daniele
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Scandinavian Journal of Immunology, 1973
In human sera showing elevated levels of IgM, the serum agglutinators may be of both IgG and IgM classes. When the quantity of IgG is very low, these antibodies may be solely of the IgM class. Elevations in IgM levels subsequent to loss of IgG through the kidney, as in nephrosis, and elevations in all immunoglobulin levels, as observed in severe ...
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In human sera showing elevated levels of IgM, the serum agglutinators may be of both IgG and IgM classes. When the quantity of IgG is very low, these antibodies may be solely of the IgM class. Elevations in IgM levels subsequent to loss of IgG through the kidney, as in nephrosis, and elevations in all immunoglobulin levels, as observed in severe ...
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Clinical Reviews in Allergy & Immunology, 2013
The hyper IgM syndromes are a group of rare inherited immune deficiency disorders characterized by impairment of immunoglobulin isotype switching resulting from defects in the CD40 ligand/CD40 signaling pathway. X-linked forms of hyper IgM are caused by defects in the CD40 ligand gene or NF-κB essential modulator, while autosomal recessive forms of ...
Nashmia, Qamar, Ramsay L, Fuleihan
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The hyper IgM syndromes are a group of rare inherited immune deficiency disorders characterized by impairment of immunoglobulin isotype switching resulting from defects in the CD40 ligand/CD40 signaling pathway. X-linked forms of hyper IgM are caused by defects in the CD40 ligand gene or NF-κB essential modulator, while autosomal recessive forms of ...
Nashmia, Qamar, Ramsay L, Fuleihan
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IgM-Associated Glomerulonephritis
Nephron, 1982In a series of 374 renal biopsy specimens, 26 from patients with primary glomerulonephritis showed IgM as the main glomerular immunofluorescence finding. By light microscopy 17 of these specimens showed mild mesangial hypercellularity and 9 were normal. Small mesangial electron-dense deposits were seen in 8 specimens.
H, Helin +3 more
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Current Opinion in Rheumatology, 2006
The recent elucidation of the molecular defects leading to hyper-IgM syndromes has provided considerable insight into the complex mechanisms that govern the antibody maturation in humans.The study of a large cohort of patients revealed unexpected clinical, immunological and genetic findings, which have significant implications on the molecular basis of
Anne, Durandy +2 more
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The recent elucidation of the molecular defects leading to hyper-IgM syndromes has provided considerable insight into the complex mechanisms that govern the antibody maturation in humans.The study of a large cohort of patients revealed unexpected clinical, immunological and genetic findings, which have significant implications on the molecular basis of
Anne, Durandy +2 more
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Induction of IgM and IgM-rheumatoid factor synthesis in vitro by indomethacin
Rheumatology International, 1991Indomethacin, which is thought to exert its therapeutic effect by inhibiting the synthesis of PGE2, is a commonly used first-line agent in the treatment of rheumatoid arthritis (RA). However, the effect of this drug on the humoral immune response in RA remains unclear. In this study, modulation of the in vitro synthesis of IgM and IgM-rheumatoid factor
J, Hassan +3 more
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IgM paraproteinaemic neuropathies
Current Opinion in Neurology, 2004To conduct a critical review of recent studies on the pathogenesis and treatment of IgM paraproteinaemic neuropathies and analyse their implication for patient management.A better definition and classification of IgM monoclonal gammopathies has led to recommendations on therapeutic strategies for these patients, particularly for those with the ...
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In vitro synthesis of IgM and IgM rheumatoid factor in seronegative arthritides
Rheumatology International, 1984In vitro patterns of IgM and IgM rheumatoid factor (RF) synthesis exhibited by peripheral blood B cells (MNL) obtained from healthy individuals as well as patients with seropositive and seronegative rheumatoid arthritis (RA) have been previously examined. The present study was performed in a group of patients with non-rheumatoid seronegative arthritis (
G S, Alarcón +2 more
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Current Allergy and Asthma Reports, 2001
The hyper IgM syndrome is a rare, inherited immune deficiency disorder resulting from defects in the CD40 ligand/CD40-signaling pathway. X-linked hyper IgM is caused by defects in the CD40 ligand gene, while autosomal recessive hyper IgM is caused by defects in the CD40-activated RNA-editing enzyme, activation-induced cytidine deaminase, which is ...
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The hyper IgM syndrome is a rare, inherited immune deficiency disorder resulting from defects in the CD40 ligand/CD40-signaling pathway. X-linked hyper IgM is caused by defects in the CD40 ligand gene, while autosomal recessive hyper IgM is caused by defects in the CD40-activated RNA-editing enzyme, activation-induced cytidine deaminase, which is ...
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