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Methods for Conjugating Antibodies with Quantum Dots. [PDF]
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IgNAR antibody: Structural features, diversity and applications
Fish and Shellfish Immunology, 2022In response to the invasion of exogenous microorganisms, one of the defence strategies of the immune system is to produce antibodies. Cartilaginous fish is among those who evolved the earliest humoral immune system that utilizes immunoglobulin-type antibodies. The cartilaginous fish antibodies fall into three categories: IgW, IgM, and IgNAR.
Tengchuan Jin +2 more
exaly +5 more sources
Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]
MAbs, 2015 In addition to antibodies with the classical composition of heavy and light chains, the adaptive immune repertoire of sharks also includes a heavy-chain only isotype, where antigen binding is mediated exclusively by a small and highly stable domain, referred to as vNAR.
Martin Empting +2 more
exaly +4 more sources
The Shark Strikes Twice: Hypervariable Loop 2 of Shark IgNAR Antibody Variable Domains and Its Potential to Function as an Autonomous Paratope [PDF]
Marine Biotechnology, 2015 In this present study, we engineered hypervariable loop 2 (HV2) of the IgNAR variable domain in a way that it solely facilitates antigen binding, potentially functioning as an autonomous paratope.
Martin Empting +2 more
exaly +2 more sources