Results 1 to 10 of about 485 (131)

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR [PDF]

Pharmaceutics, 2020
Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation.
Elodie Pothin, Dominique Lesuisse, Pierre Lafaye   +2 more
doaj   +4 more sources

Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3.

PLoS ONE, 2019
The variable domain of New Antigen Receptors (vNAR) from sharks, present special characteristics in comparison to the conventional antibody molecules such as: small size (12-15 kDa), thermal and chemical stability and great tissue penetration, that makes
Olivia Cabanillas-Bernal, Salvador Dueñas, Marta Ayala-Avila, Alexandra Rucavado, Teresa Escalante, Alexei F Licea-Navarro   +5 more
doaj   +3 more sources

In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development

Journal of Immunology Research, 2020
Anti-drug antibodies (ADAs), specific for biotherapeutic drugs, are associated with reduced serum drug levels and compromised therapeutic response. The impact of ADA on the bioavailability and clinical efficacy of blockbuster anti-hTNF-α monoclonal ...
Obinna C. Ubah, Andrew J. Porter, Caroline J. Barelle   +2 more
doaj   +2 more sources

Specific Targeting of Lymphoma Cells Using Semisynthetic Anti-Idiotype Shark Antibodies

Frontiers in Immunology, 2020
The B-cell receptor (BCR) is a key player of the adaptive immune system. It is a unique part of immunoglobulin (Ig) molecules expressed on the surface of B cells. In case of many B-cell lymphomas, the tumor cells express a tumor-specific and functionally
Arturo Macarrón Palacios, Julius Grzeschik, Lukas Deweid, Simon Krah, Stefan Zielonka, Thies Rösner, Matthias Peipp, Thomas Valerius, Harald Kolmar   +8 more
doaj   +1 more source

Central Nervous System Delivery of Antibodies and Their Single-Domain Antibodies and Variable Fragment Derivatives with Focus on Intranasal Nose to Brain Administration

Antibodies, 2021
IgG antibodies are some of the most important biopharmaceutical molecules with a high market volume. In spite of the fact that clinical therapies with antibodies are broadly utilized in oncology, immunology and hematology, their delivery strategies and ...
Arghavan Soleimanizadeh, Heiko Dinter, Katharina Schindowski   +2 more
doaj   +1 more source

Transportation of Single-Domain Antibodies through the Blood–Brain Barrier

Biomolecules, 2021
Single-domain antibodies derive from the heavy-chain-only antibodies of Camelidae (camel, dromedary, llama, alpaca, vicuñas, and guananos; i.e., nanobodies) and cartilaginous fishes (i.e., VNARs).
Eduardo Ruiz-López, Alberto J. Schuhmacher   +1 more
doaj   +1 more source

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Frontiers in Immunology, 2019
Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases.
Obinna C. Ubah, John Steven, Andrew J. Porter, Andrew J. Porter, Caroline J. Barelle   +4 more
doaj   +1 more source

Vaccinoted Augmented Reality (VNAR): Vaccine Knowledge for Raising Awareness of Immunisation Among School Children

Malaysia Journal of Invention and Innovation, 2023
People may now instantly obtain any information they desire thanks to the advancements in technology. Unfortunately, technological development can also result in grave issues, such as irresponsible anti-vaccine advocates who disseminate incorrect ...
Siti Nur Irdina Alwi, Suzidiana Sulaiman
doaj   +2 more sources

Efficient Construction and Effective Screening of Synthetic Domain Antibody Libraries

Methods and Protocols, 2019
Phage display is a powerful technique for drug discovery in biomedical research in particular for antibody libraries. But, several technical challenges are associated with the selection process.
Arghavan Solemani Zadeh, Alissa Grässer, Heiko Dinter, Maximilian Hermes, Katharina Schindowski   +4 more
doaj   +1 more source

Single Domain Antibodies as New Biomarker Detectors

Diagnostics, 2017
Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow, Katja Fischer, Chiuan Yee Leow, Qin Cheng, Candy Chuah, James McCarthy   +5 more
doaj   +1 more source