Results 41 to 50 of about 485 (131)
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development [PDF]
Frontiers in Immunology, 2017 Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice.
John Steven +11 more
doaj +4 more sources
Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of Concern [PDF]
International Journal of Molecular Sciences, 2022 Blanca J Valdovino-Navarro +2 more
exaly +2 more sources
vNARs as Neutralizing Intracellular Therapeutic Agents: Glioblastoma as a Target. [PDF]
Antibodies (Basel)Glioblastoma is the most prevalent and fatal form of primary brain tumors. New targeted therapeutic strategies for this type of tumor are imperative given the dire prognosis for glioblastoma patients and the poor results of current multimodal therapy.
Manzanares-Guzmán A +2 more
europepmc +4 more sources
Applied Sciences, 2023 The shark-derived single-domain antibody VNAR (variable domain of new antigen receptor) has many advantageous features that make the VNAR suitable for improving current monoclonal antibody therapy deficiencies or disease diagnosis methods.
Chia-Hung Tsai +3 more
doaj +1 more source
Shark-derived single-domain antibodies for the detection of decapod iridescent virus 1
Aquaculture Reports, 2023 Decapod iridescent virus 1 (DIV1) has emerged as a novel threat to shrimp farming. The development of a rapid, convenient, and accurate method for diagnosing DIV1 is urgently needed, serving as a key factor in the reduction of the risk of viral outbreaks.
Jinlin Chen +6 more
doaj +1 more source
Small Methods, Volume 6, Issue 7, July 20, 2022., 2022 Shark‐derived vnarbodies 20G6 and 17F6 broadly neutralize SARS‐CoV‐2 Wuhan, Alpha, Beta, Kappa, Delta, Delta‐plus, Lambda variants, and sarbecovirus coronaviruses, but are unexpectedly ineffective for Omicron. Intranasal administration of 20G6 confers effective preventive and therapeutic effects in mice infected with SARS‐CoV‐2 Wuhan and Beta variant ...
Bo Feng +21 more
wiley +1 more source
Detection of genome‐edited and endogenously expressed G protein‐coupled receptors
The FEBS Journal, Volume 288, Issue 8, Page 2585-2601, April 2021., 2021 G protein‐coupled receptors (GPCRs) are the largest family of membrane receptors and major targets for FDA‐approved drugs. Quantifying GPCR expression and ligand binding characteristics in different cell types is important for drug discovery. The advent of genome editing and developments in fluorescent ligand design offers exciting possibilities to ...
Mark Soave +6 more
wiley +1 more source
Journal of Materials Chemistry B, 2023 Vinyl sulfone (VS) functionalization – An innovative conjugation approach for preparation of variable new antigen receptor (VNAR) targeted polymeric nanoparticles.
Adam Leach +9 more
openaire +4 more sources
Frontiers in Molecular Biosciences, 2021 Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system.
Monica L. Fernández-Quintero +3 more
doaj +1 more source
Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications
Cells, 2021 Shark is a cartilaginous fish that produces new antigen receptor (IgNAR) antibodies. This antibody is identified with a similar human heavy chain but dissimilar sequences.
Salma Nassor Juma +6 more
doaj +1 more source