Results 41 to 50 of about 1,385 (169)

Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of Concern [PDF]

International Journal of Molecular Sciences, 2022
Blanca Valdovinos Navarro, Salvador Dueñas, Jahaziel Gasperin-Bulbarela   +2 more
exaly   +2 more sources

The screening and anti-Raji lymphoma effect of Chiloscyllium plagiosum anti-CD20 VNARs

Frontiers in Marine Science
IntroductionB-cell lymphoma, a malignant proliferative disease originating from lymphoid tissue, poses a grave threat to human health. CD20 has emerged as a promising target for lymphoma treatment.
Qingyu Ren, Yu Sheng, Yu Sheng, Ling Sun, Feijian Zheng, Chengwu Hu, Jianqing Chen, Zhengbing Lyu, Chen Yuan, Xiaofeng Jiang, Xiaofeng Jiang, Xiaofeng Jiang   +11 more
doaj   +2 more sources

vNARs as Neutralizing Intracellular Therapeutic Agents: Glioblastoma as a Target. [PDF]

Antibodies (Basel)
Glioblastoma is the most prevalent and fatal form of primary brain tumors. New targeted therapeutic strategies for this type of tumor are imperative given the dire prognosis for glioblastoma patients and the poor results of current multimodal therapy.
Manzanares-Guzmán A, Lugo-Fabres PH, Camacho-Villegas TA.   +2 more
europepmc   +4 more sources

Yeast Surface Dual Display Platform for Rapid Discovery of Shark VNAR from a Semi-Synthetic Library Followed by Next-Generation Sequencing

Applied Sciences, 2023
The shark-derived single-domain antibody VNAR (variable domain of new antigen receptor) has many advantageous features that make the VNAR suitable for improving current monoclonal antibody therapy deficiencies or disease diagnosis methods.
Chia-Hung Tsai, Kuang-Teng Wang, Xuan Guo, Tsung-Meng Wu   +3 more
doaj   +1 more source

Shark-derived single-domain antibodies for the detection of decapod iridescent virus 1

Aquaculture Reports, 2023
Decapod iridescent virus 1 (DIV1) has emerged as a novel threat to shrimp farming. The development of a rapid, convenient, and accurate method for diagnosing DIV1 is urgently needed, serving as a key factor in the reduction of the risk of viral outbreaks.
Jinlin Chen, Wei Wang, Qin Zheng, Yunying Cheng, Qian Zhang, Shenfei Jiang, Jianming Chen   +6 more
doaj   +1 more source

A Class of Shark‐Derived Single‐Domain Antibodies can Broadly Neutralize SARS‐Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape

Small Methods, Volume 6, Issue 7, July 20, 2022., 2022
Shark‐derived vnarbodies 20G6 and 17F6 broadly neutralize SARS‐CoV‐2 Wuhan, Alpha, Beta, Kappa, Delta, Delta‐plus, Lambda variants, and sarbecovirus coronaviruses, but are unexpectedly ineffective for Omicron. Intranasal administration of 20G6 confers effective preventive and therapeutic effects in mice infected with SARS‐CoV‐2 Wuhan and Beta variant ...
Bo Feng, Zhilong Chen, Jing Sun, Tingting Xu, Qian Wang, Haisu Yi, Xuefeng Niu, Jiabin Zhu, Mengzhu Fan, Ruitian Hou, Ying Shao, Sihui Huang, Cuiyun Li, Peiyu Hu, Pingqian Zheng, Ping He, Jia Luo, Qihong Yan, Xiaoli Xiong, Jinsong Liu, Jincun Zhao, Ling Chen   +21 more
wiley   +1 more source

Detection of genome‐edited and endogenously expressed G protein‐coupled receptors

The FEBS Journal, Volume 288, Issue 8, Page 2585-2601, April 2021., 2021
G protein‐coupled receptors (GPCRs) are the largest family of membrane receptors and major targets for FDA‐approved drugs. Quantifying GPCR expression and ligand binding characteristics in different cell types is important for drug discovery. The advent of genome editing and developments in fluorescent ligand design offers exciting possibilities to ...
Mark Soave, Leigh A. Stoddart, Carl W. White, Laura E. Kilpatrick, Joëlle Goulding, Stephen J. Briddon, Stephen J. Hill   +6 more
wiley   +1 more source

Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation

Journal of Materials Chemistry B, 2023
Vinyl sulfone (VS) functionalization – An innovative conjugation approach for preparation of variable new antigen receptor (VNAR) targeted polymeric nanoparticles.
Adam Leach, Marie Finnegan, Mariana S. Machado, Laura Ferguson, John Steven, Peter Smyth, Andrew Porter, Caroline Barelle, Efrosyni Themistou, Christopher J. Scott   +9 more
openaire   +4 more sources

Herschel-HIFI observations of H2O, NH3 and N2H+ toward high-mass starless and proto-stellar clumps identified by the Hi-GAL survey [PDF]

, 2015
Our present understanding of high-mass star formation still remains very schematic. In particular, it is not yet clear how much of the difference between low-mass and high-mass star formation occurs during the earliest star formation phases. The chemical
Codella, Claudio, Olmi, Luca, Persson, Carina M.   +2 more
core   +4 more sources

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity [PDF]

, 2009
Antibodies are important tools for experimental research and medical applications. Most antibodies are composed of two heavy and two light chains. Both chains contribute to the antigen-binding site which is usually flat or concave.
Janusz Wesolowski, Vanina Alzogaray, Jan Reyelt, Mandy Unger, Karla Juarez, Mariela Urrutia, Ana Cauerhff, Welbeck Danquah, Björn Rissiek, Felix Scheuplein, Nicole Schwarz, Sahil Adriouch, Olivier Boyer, Michel Seman, Alexei Licea, David V. Serreze, Fernando A. Goldbaum, Friedrich Haag, Friedrich Koch-Nolte, OH Brekke, C Hamers-Casterman, S Muyldermans, P Holliger, A Desmyter, E De Genst, TT Wu, MM Harmsen, A Pini, HR Hoogenboom, V Cortez-Retamozo, M Dumoulin, EK Conrath, U Rothbauer, A Olichon, K Coppieters, N Pant, D Gueorguieva, SA Jobling, B Serruys, M Feldmann, N Lonberg, A Drucker, JW Goding, M Salmi, D Corda, A Zolkiewska, F Di Virgilio, F Koch-Nolte, S Adriouch, F Koch-Nolte, F Scheuplein, S Adriouch, M Seman, V Ghetie, G Behar, AJ Groot, A Muruganandam, A Abulrob, V Cortez-Retamozo, K Omidfar, R Roovers, L Huang, BM Tijink, F Rahbarizadeh, D Ahmadvand, MA Palladino, DR Maass, W Wolfson, JJ Hulstein, D Schenk, M Dumoulin, P Lafaye, G Habicht, R Klooster, C Cohen-Saidon, C Avignolo, AJ Groot, AJ Groot, P Verheesen, D Laune, A Marquardt, DA Laplagne, LM Zarebski, DP Simmons, T Gura, K Strebhardt, K Aktories, ER Goldman, JL Liu, ER Goldman, M El Khattabi, RA Harrison, F Meddeb-Mouelhi, RA Harrison, CS Stewart, I Hmila, PJ Doyle, S Spinelli, RC Ladenson, GP Anderson, N Alvarez-Rueda, DM Goldenberg, A Forsman, L Garaicoechea, MM Harmsen, MM Harmsen, A Hultberg, HJ de Haard, AM Ledeboer, S Dekker, LJ Sherwood, MM Harmsen, A Szynol, C Krüger, KV Korotkov, AY Lam, S Spinelli, KE Conrath, B Stijlemans, TN Baral, D Saerens, L Ratier, N Deckers, E Dolk, AS Greenberg, C Vincke, X Zou, R Janssens, EG Hofman, LO Gainkam, F Rahbarizadeh, S Winichayakul, D Saerens, D Saerens, PH Chan, A Chartier, S van Koningsbruggen, JL Liu, JM van der Vaart, MM Harmsen, KA Henderson, W DeLano, RL Stanfield, AT Hadfield, BC Braden, MR Bazl, U Rothbauer   +146 more
core   +6 more sources