Results 41 to 50 of about 691 (170)
Small Methods, Volume 6, Issue 7, July 20, 2022., 2022 Shark‐derived vnarbodies 20G6 and 17F6 broadly neutralize SARS‐CoV‐2 Wuhan, Alpha, Beta, Kappa, Delta, Delta‐plus, Lambda variants, and sarbecovirus coronaviruses, but are unexpectedly ineffective for Omicron. Intranasal administration of 20G6 confers effective preventive and therapeutic effects in mice infected with SARS‐CoV‐2 Wuhan and Beta variant ...
Bo Feng +21 more
wiley +1 more source
Isolation and Characterization of the First Antigen-Specific EGFRvIII vNAR from Freshwater Stingray (<i>Potamotrygon</i> spp.) as a Drug Carrier in Glioblastoma Cancer Cells. [PDF]
Int J Mol SciGlioblastoma is the most common and highly malignant brain tumor in adults. New targeted therapeutic approaches are imperative. EGFRvIII has appealing therapeutic targets using monoclonal antibodies.
Manzanares-Guzmán A +7 more
europepmc +2 more sources
Detection of genome‐edited and endogenously expressed G protein‐coupled receptors
The FEBS Journal, Volume 288, Issue 8, Page 2585-2601, April 2021., 2021 G protein‐coupled receptors (GPCRs) are the largest family of membrane receptors and major targets for FDA‐approved drugs. Quantifying GPCR expression and ligand binding characteristics in different cell types is important for drug discovery. The advent of genome editing and developments in fluorescent ligand design offers exciting possibilities to ...
Mark Soave +6 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2021 Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system.
Monica L. Fernández-Quintero +3 more
doaj +1 more source
Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications
Cells, 2021 Shark is a cartilaginous fish that produces new antigen receptor (IgNAR) antibodies. This antibody is identified with a similar human heavy chain but dissimilar sequences.
Salma Nassor Juma +6 more
doaj +1 more source
, 2022 Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR
Klaus R. Liedl (1235931) +5 more
core +1 more source
Molecular Therapy: Oncolytics, 2022 Chimeric antigen receptor (CAR)-T cell therapy shows excellent potency against hematological malignancies, but it remains challenging to treat solid tumors, mainly because of a lack of appropriate antigenic targets and an immunosuppressive tumor ...
Dan Li +6 more
doaj +1 more source
Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain [PDF]
mAbs, 2012 Advances in recombinant antibody technology and protein engineering have provided the opportunity to reduce antibodies to their smallest binding domain components and have concomitantly driven the requirement for devising strategies to increase serum half-life to optimise drug exposure, thereby increasing therapeutic efficacy. In this study, we adopted
Mischa R, Müller +15 more
openaire +2 more sources
Nature Communications, 2021 Shark antibodies (Variable New Antigen Receptors, VNARs) are the smallest naturally occurring antibody fragments. Here, the authors screen a VNAR phage display library against the SARS-CoV2 receptor binding domain (RBD) and identify VNARs that neutralize
Obinna C. Ubah +20 more
doaj +1 more source
Malaria Journal, 2018 Background Malaria rapid diagnostic tests (RDTs) represent an important antibody based immunoassay platform. Unfortunately, conventional monoclonal antibodies are subject to degradation shortening shelf lives of RDTs. The variable region of the receptor (
Chiuan Herng Leow +5 more
doaj +1 more source