The characterization of variable new antigen receptors targeting FAP isolated from a novel immunized library [PDF]
Communications BiologyCancer-associated fibroblasts (CAFs) in the stroma of solid tumors promote an immunosuppressive tumor microenvironment (TME) that drives resistance to therapies.
Gihan S. Gunaratne +15 more
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Screening and characterization of inhibitory vNAR targeting nanodisc-assembled influenza M2 proteins
iScience, 2023 Summary: Influenza A virus poses a constant challenge to human health. The highly conserved influenza matrix-2 (M2) protein is an attractive target for the development of a universal antibody-based drug.
Chuandi Yu +26 more
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The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors [PDF]
Nature CommunicationsThe pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) is synthesized as transmembrane TNF-α (tmTNF-α) where proteolytic processing releases soluble TNF-α (sTNF-α).
Obinna C. Ubah +13 more
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Unleashing the power of shark variable single domains (VNARs): broadly neutralizing tools for combating SARS-CoV-2 [PDF]
Frontiers in Immunology, 2023 The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a joint global effort to develop vaccines and other treatments that could mitigate the negative effects and the rapid spread of the virus.
Olivia Cabanillas-Bernal +4 more
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Unique antibodies across the animal kingdom (birds, camelids, and sharks): therapeutic potential against human respiratory viral infections [PDF]
Frontiers in ImmunologyAntibodies represent indispensable tools in the armamentarium against infectious diseases, with widespread application in prophylactic, therapeutic, and diagnostic settings.
Ammar A. Basabrain +3 more
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CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration [PDF]
Pharmaceutics, 2023 Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy.
Pawel Stocki +11 more
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A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization [PDF]
Frontiers in Immunology, 2023 IntroductionO-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA).
Xiaozhi Xi +21 more
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Preparation of pH-sensitive nanogels bioconjugated with shark antibodies (VNAR) for targeted drug delivery with potential applications in colon cancer therapies. [PDF]
PLoS ONECancer is the second leading cause of death worldwide. To combat this disease, novel and specialized therapeutic systems are urgently needed. This is the first study to explore a system that combines shark variable domain (Fv) of new antigen receptor ...
Lizbeth A Manzanares-Guevara +6 more
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Nanobody-enhanced chimeric antigen receptor T-cell therapy: overcoming barriers in solid tumors with VHH and VNAR-based constructs [PDF]
Biomarker ResearchCAR-T cells are genetically modified T lymphocytes that express chimeric antigen receptors (CAR) on their surfaces. These receptors enable T lymphocytes to recognize specific antigens on target cells, triggering a response that leads to targeted ...
Shasha Guo, Xiaozhi Xi
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The screening and anti-Raji lymphoma effect of Chiloscyllium plagiosum anti-CD20 VNARs
Frontiers in Marine ScienceIntroductionB-cell lymphoma, a malignant proliferative disease originating from lymphoid tissue, poses a grave threat to human health. CD20 has emerged as a promising target for lymphoma treatment.
Qingyu Ren +11 more
doaj +2 more sources