Results 31 to 40 of about 1,385 (169)

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR [PDF]

Pharmaceutics, 2020
Passive immunotherapy, i.e., treatment with therapeutic antibodies, has been increasingly used over the last decade in several diseases such as cancers or inflammation.
Elodie Pothin, Dominique Lesuisse, Pierre Lafaye   +2 more
doaj   +4 more sources

A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer

Molecular Therapy - Oncolytics, 2022
Chimeric antigen receptor (CAR)-T cell therapy shows excellent potency against hematological malignancies, but it remains challenging to treat solid tumors, mainly because of a lack of appropriate antigenic targets and an immunosuppressive tumor ...
Tianyuzhou Liang, Glenn Merlino, Chi-Ping Day   +2 more
exaly   +3 more sources

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model [PDF]

Frontiers in Immunology, 2019
Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases.
Obinna C. Ubah, John Steven, Andrew J. Porter, Andrew J. Porter, Caroline J. Barelle   +4 more
doaj   +4 more sources

Unique antibodies across the animal kingdom (birds, camelids, and sharks): therapeutic potential against human respiratory viral infections [PDF]

Frontiers in Immunology
Antibodies represent indispensable tools in the armamentarium against infectious diseases, with widespread application in prophylactic, therapeutic, and diagnostic settings.
Ammar A. Basabrain, Ammar A. Basabrain, Thamir A. Alandijany, Thamir A. Alandijany   +3 more
doaj   +2 more sources

PLAbDab-nano: a database of camelid and shark nanobodies from patents and literature. [PDF]

Nucleic Acids Res
Nanobodies are essential proteins of the adaptive immune systems of camelid and shark species, complementing conventional antibodies. Properties such as their relatively small size, solubility and high thermostability make VHH (variable heavy domain of ...
Gordon GL, Greenshields-Watson A, Agarwal P, Wong A, Boyles F, Hummer A, Lujan Hernandez AG, Deane CM.   +7 more
europepmc   +3 more sources

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications [PDF]

Antibodies, 2013
The single variable new antigen receptor domain antibody fragments (VNARs) derived from shark immunoglobulin new antigen receptor antibodies (IgNARs) represent some of the smallest known immunoglobulin-based protein scaffolds.
Stewart Nuttall, Matthew A. Perugini, Iveth González, Joanne L. Casey, Abdulmonem Sanalla, Miles Barraclough, Con Dogovski, Julie Angerosa, Kathy Parisi, Olan Dolezal, Katherine Griffiths, Michael Foley   +11 more
doaj   +2 more sources

A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization [PDF]

Frontiers in Immunology, 2023
IntroductionO-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA).
Xiaozhi Xi, Xiaozhi Xi, Xiaozhi Xi, Guokai Xiao, Guokai Xiao, Guokai Xiao, Guiqi An, Lin Liu, Xiaochun Liu, Peiyu Hao, Peiyu Hao, Peiyu Hao, Jennifer Yiyang Wang, Dandan Song, Dandan Song, Dandan Song, Wengong Yu, Wengong Yu, Wengong Yu, Yuchao Gu, Yuchao Gu, Yuchao Gu   +21 more
doaj   +2 more sources

Preparation of pH-sensitive nanogels bioconjugated with shark antibodies (VNAR) for targeted drug delivery with potential applications in colon cancer therapies. [PDF]

PLoS ONE
Cancer is the second leading cause of death worldwide. To combat this disease, novel and specialized therapeutic systems are urgently needed. This is the first study to explore a system that combines shark variable domain (Fv) of new antigen receptor ...
Lizbeth A Manzanares-Guevara, Jahaziel Gasperin-Bulbarela, Olivia Cabanillas-Bernal, Monserrat Renteria-Maciel, Angel Licea-Claverie, Eugenio R Méndez, Alexei F Licea-Navarro   +6 more
doaj   +2 more sources

Nanobody-enhanced chimeric antigen receptor T-cell therapy: overcoming barriers in solid tumors with VHH and VNAR-based constructs [PDF]

Biomarker Research
CAR-T cells are genetically modified T lymphocytes that express chimeric antigen receptors (CAR) on their surfaces. These receptors enable T lymphocytes to recognize specific antigens on target cells, triggering a response that leads to targeted ...
Shasha Guo, Xiaozhi Xi
doaj   +2 more sources

Identification of nurse shark V_NAR single-domain antibodies targeting the spike S2 subunit of SARS-CoV-2. [PDF]

FASEB J, 2023
Shark VNAR nanobodies targeting the S2 subunit of SARS‐CoV‐2 spike protein were identified from a naïve nurse shark VNAR phage display library by phage panning. The S2A9 VNAR showed the best neutralization activity against the original pseudotyped virus and was further characterized.
Buffington J, Duan Z, Kwon HJ, Hong J, Li D, Feng M, Xie H, Ho M.   +7 more
europepmc   +2 more sources