Results 11 to 20 of about 1,385 (169)

Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization [PDF]

Marine Drugs, 2018
Variable new antigen receptor domain (vNAR) antibodies are novel, naturally occurring antibodies that can be isolated from naïve, immune or synthetic shark libraries. These molecules are very interesting to the biotechnology and pharmaceutical industries
Tanya Camacho-Villegas, Walter Garcia-Ubbelohde, Alexei Licea-Navarro   +2 more
exaly   +5 more sources

In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development [PDF]

Journal of Immunology Research, 2020
Anti-drug antibodies (ADAs), specific for biotherapeutic drugs, are associated with reduced serum drug levels and compromised therapeutic response. The impact of ADA on the bioavailability and clinical efficacy of blockbuster anti-hTNF-α monoclonal ...
Obinna C. Ubah, Andrew J. Porter, Caroline J. Barelle   +2 more
doaj   +3 more sources

Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy [PDF]

Frontiers in Pharmacology, 2023
Aberrant activity of the cysteine protease Cathepsin S (CTSS) has been implicated across a wide range of pathologies. Notably in cancer, CTSS has been shown to promote tumour progression, primarily through facilitating invasion and migration of tumour ...
P. Smyth, L. Ferguson, J. F. Burrows, R. E. Burden, S. R. Tracey, Ú. M. Herron, M. Kovaleva, R. Williams, A. J. Porter, A. J. Porter, D. B. Longley, C. J. Barelle, C. J. Scott   +12 more
doaj   +6 more sources

Identification and characterization of IgNAR and VNAR repertoire from the ocellate spot skate (Okamejei kenojei)

Frontiers in Marine Science, 2023
Elasmobranchs are crucial for comparative studies of evolution, as they belong to the most ancient vertebrate lineages that survived numerous extinction events and persist until today.
Jianqing Wen, Jianqing Wen, Jinyu Gong, Jinyu Gong, Pengwei Li, Penghui Deng, Penghui Deng, Mengsi Sun, Yujie Wu, Chenxi Tian, Chenxi Tian, Hao Wang, Yunchen Bi, Yunchen Bi, Yunchen Bi   +14 more
exaly   +4 more sources

A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy [PDF]

Acta Pharmaceutica Sinica B
TROP-2, a tumor-associated antigen, has been implicated in the progression of various epithelial tumors. Due to its favorable expression profile, TROP-2 has emerged as a promising target for antibody-drug conjugates (ADCs) based anti-tumor therapies. Although ADCs have shown efficacy in cancer treatment, their application in solid tumors is hindered by
Yanqing Wang, Zhicheng Zuo, Qiang Wang
exaly   +4 more sources

Brain delivery of biologics using a cross‐species reactive transferrin receptor 1 VNAR shuttle [PDF]

The FASEB Journal, Volume 34, Issue 10, Page 13272-13283, October 2020., 2020
Abstract Transferrin receptor 1 (TfR1) mediated transcytosis is an attractive strategy to enhance brain uptake of protein drugs, but translation remains a challenge. Here, a single domain shark antibody VNAR fragment (TXB2) with similar affinity to murine and human TfR1 was used to shuttle protein cargo into the brain. TXB2 was fused to a human IgG1 Fc
Dag Sehlin, Pawel Stocki, Tobias Gustavsson, Greta Hultqvist, Frank S. Walsh, J. Lynn Rutkowski, Stina Syvänen   +6 more
wiley   +4 more sources

Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum)

Marine Drugs, 2022
Tumor necrosis factor α (TNFα), an important clinical testing factor and drug target, can trigger serious autoimmune diseases and inflammation. Thus, the TNFα antibodies have great potential application in diagnostics and therapy fields.
Linfei Zhao, Mingliang Chen, Xiaona Wang, Shoukai Kang, Weiwei Xue, Zengpeng Li   +5 more
doaj   +3 more sources

VNAR: shark single-domain antibodies for the new era of medical biotechnology [PDF]

Frontiers in Immunology
Shark-derived single-domain antibodies, known as VNARs, represent unique and advanced tools in medical biotechnology. Recognized for their small size, simple structure, and exceptional stability, VNARs can access cryptic epitopes that are inaccessible to
Richard A. Olivares-Olivares, Richard A. Olivares-Olivares, Angélica R. Bravo, Angélica R. Bravo, Carlos Garrido-Soto, Carlos Garrido-Soto, Jonatan J. Carvajal, Jonatan J. Carvajal, Augusto Manubens, Mariella Rivas, Mariella Rivas, Carlos Bustamente, Angello Retamal-Díaz, Angello Retamal-Díaz, Angello Retamal-Díaz, Alexis M. Kalergis, Alexis M. Kalergis, Margarita K. Lay, Margarita K. Lay, Margarita K. Lay   +19 more
doaj   +2 more sources

Identification and characterization of shark VNARs targeting the Helicobacter pylori adhesin HpaA

Artificial Cells, Nanomedicine, and Biotechnology, 2023
Helicobacter pylori (H. pylori) is recognized as a pathogen associated with several gastrointestinal diseases. The current treatments exhibit numerous drawbacks, including antibiotic resistance. H.
Yanchun Gao, Ruihong Wang, Lin Liu, Shitao Feng, Xiaozhi Xi, Wengong Yu, Yuchao Gu, Ye Wang   +7 more
doaj   +3 more sources

Development and application of a VNAR-based detection nanobody for avian influenza virus H9N2 [PDF]

Frontiers in Immunology
The H9N2 subtype avian influenza virus, as a mutant strain of low-pathogenic avian influenza (LPAI), has augmented its transmission ability and pathogenicity via genetic evolution.
Hongzhou Ye, Qingqing Dong, Min Qian, Yanwen Guo, Yi Chen, Wenyuan Liu, Lili Liu, Zhengbing Lyu, Chen Yuan, Xiaofeng Jiang   +9 more
doaj   +2 more sources