VNAR development through antigen immunization of Japanese topeshark (Hemitriakis japanica) [PDF]
Frontiers in Bioengineering and Biotechnology, 2023 The VNAR (Variable New Antigen Receptor) is the smallest single-domain antibody derived from the variable domain of IgNAR of cartilaginous fishes. Despite its biomedical and diagnostic potential, research on VNAR has been limited due to the difficulties ...
Takeda Hiroyuki +2 more
exaly +6 more sources
Construction and application of a large capacity VNAR library from the whitespotted bamboo shark (Chiloscyllium playgiosum) [PDF]
Acta Pharmaceutica Sinica BFifty whitespotted bamboo sharks (Chiloscyllium playgiosum) of both sexes were used to establish a large capacity variable domain of the new antigen receptor (VNAR) library with a total capacity of over 109 colony-forming units (CFU).
Chuan-Wei Chen +2 more
exaly +6 more sources
Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization [PDF]
Marine Drugs, 2018 Variable new antigen receptor domain (vNAR) antibodies are novel, naturally occurring antibodies that can be isolated from naïve, immune or synthetic shark libraries. These molecules are very interesting to the biotechnology and pharmaceutical industries
Tanya A Camacho-Villegas +2 more
exaly +5 more sources
The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles [PDF]
Frontiers in Immunology, 2022 Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR
Monica L. Fernández-Quintero +5 more
doaj +4 more sources
VNAR: shark single-domain antibodies for the new era of medical biotechnology [PDF]
Frontiers in ImmunologyShark-derived single-domain antibodies, known as VNARs, represent unique and advanced tools in medical biotechnology. Recognized for their small size, simple structure, and exceptional stability, VNARs can access cryptic epitopes that are inaccessible to
Richard A. Olivares-Olivares +19 more
doaj +4 more sources
Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy [PDF]
Frontiers in Pharmacology, 2023 Aberrant activity of the cysteine protease Cathepsin S (CTSS) has been implicated across a wide range of pathologies. Notably in cancer, CTSS has been shown to promote tumour progression, primarily through facilitating invasion and migration of tumour ...
P. Smyth +12 more
doaj +6 more sources
Development and application of a VNAR-based detection nanobody for avian influenza virus H9N2 [PDF]
Frontiers in ImmunologyThe H9N2 subtype avian influenza virus, as a mutant strain of low-pathogenic avian influenza (LPAI), has augmented its transmission ability and pathogenicity via genetic evolution.
Hongzhou Ye +9 more
doaj +3 more sources
Frontiers in Marine Science, 2023 Elasmobranchs are crucial for comparative studies of evolution, as they belong to the most ancient vertebrate lineages that survived numerous extinction events and persist until today.
Yujie Wu
exaly +4 more sources
Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain [PDF]
Open Biology, 2016 The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects.
Selena G. Burgess +6 more
doaj +6 more sources
Novel Approach for Obtaining Variable Domain of New Antigen Receptor with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica) [PDF]
Marine Drugs, 2023 Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has attracted attention owing to its favorable physicochemical properties.
Tomofumi Nakada-Masuta +2 more
doaj +2 more sources