Results 1 to 10 of about 840,523 (162)
Chimeric non-antigen receptors in T cell-based cancer therapy
Journal for ImmunoTherapy of Cancer, 2021 Adoptively transferred T cell-based cancer therapies have shown incredible promise in treatment of various cancers. So far therapeutic strategies using T cells have focused on manipulation of the antigen-recognition machinery itself, such as through ...
Andrew Kent, Eduardo Davila, Jitao Guo
doaj +1 more source
Toward high-throughput engineering techniques for improving CAR intracellular signaling domains
Frontiers in Bioengineering and Biotechnology, 2023 Chimeric antigen receptors (CAR) are generated by linking extracellular antigen recognition domains with one or more intracellular signaling domains derived from the T-cell receptor complex or various co-stimulatory receptors.
Savannah E. Butler +7 more
doaj +1 more source
Discovering immunoreceptor coupling and organization motifs
Frontiers in Immunology, 2023 The recently determined cryo-EM structures of the T cell antigen receptor (TCR) and B cell antigen receptor (BCR) show in molecular details the interactions of the ligand-binding part with the signaling subunits but they do not reveal the signaling ...
Michael Reth, Michael Reth
doaj +1 more source
Therapeutic applications of engineered chimeric antigen receptors-T cell for cancer therapy
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Findings of new targeted treatments with adequate safety evaluations are essential for better cancer cures and mortality rates. Immunotherapy holds promise for patients with relapsed disease, with the ability to elicit long-term remissions ...
Amina Hussain
doaj +1 more source
Interaction of b-cell receptors and antigens with different spatial arrangement
Инфекция и иммунитет, 2023 B-cell receptors can interact with antigen epitopes on various objects: macromolecules, microorganisms or on the surface of other cells, e.g., follicular dendritic cells. Accordingly, B cells, on the one hand, have the ability to evaluate the location of
Vladimir Yu. Talayev +5 more
doaj +1 more source
Unlocking the potential of Tregs: innovations in CAR technology
Frontiers in Molecular Biosciences, 2023 Regulatory T cells (Tregs) adoptive immunotherapy is emerging as a viable treatment option for both autoimmune and alloimmune diseases. However, numerous challenges remain, including limitations related to cell number, availability of target-specific ...
Christopher J. Requejo Cier +2 more
doaj +1 more source
Nature Communications, 2023 Chimeric antigen receptors (CARs) and synthetic Notch (synNotch) receptors are engineered cell-surface receptors that sense a target antigen and respond by activating T cell receptor signaling or a customized gene program, respectively.
Elisa Ruffo +10 more
doaj +1 more source
A transfer-learning approach to predict antigen immunogenicity and T-cell receptor specificity
eLife, 2023 Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key properties underlying effective immune responses. Here we propose diffRBM, an approach based on transfer learning and Restricted Boltzmann Machines, to build ...
Barbara Bravi +6 more
doaj +1 more source
Chimeric Antigen Receptors for T-Cell Malignancies
Frontiers in Oncology, 2019 Development of chimeric antigen receptor (CAR)-modified T cells for the treatment of T-lineage leukemia and lymphoma has encountered several unique challenges. The most widely expressed tumor antigen targets for malignant T cells are often also expressed
Lauren D. Scherer +8 more
doaj +1 more source
Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
Nature Communications, 2020 Chimeric antigen receptors (CAR) use antibody variable regions to activate anti-tumor immunity. Here the authors show that a mouse IgH/IgL variable region used in a clinical CAR induces host immune responses to possibly reduce therapy efficacy, but an ...
Norris Lam +5 more
doaj +1 more source