Results 11 to 20 of about 840,622 (261)
Chimeric antigen receptors that trigger phagocytosis
eLife, 2018 Chimeric antigen receptors (CARs) are synthetic receptors that reprogram T cells to kill cancer. The success of CAR-T cell therapies highlights the promise of programmed immunity and suggests that applying CAR strategies to other immune cell lineages may
Meghan A Morrissey +6 more
doaj +1 more source
Research Progress of Dendritic Cell Surface Receptors and Targeting
Biomedicines, 2023 Dendritic cells are the only antigen-presenting cells capable of activating naive T cells in humans and mammals and are the most effective antigen-presenting cells.
Chunyu Tong +6 more
doaj +1 more source
EVOLUTION OF ANTIGEN BINDING RECEPTORS [PDF]
Annual Review of Immunology, 1999 ▪ Abstract This review addresses issues related to the evolution of the complex multigene families of antigen binding receptors that function in adaptive immunity. Advances in molecular genetic technology now permit the study of immunoglobulin (Ig) and T cell receptor (TCR) genes in many species that are not commonly studied yet represent critical ...
Litman, Gary W. +2 more
openaire +3 more sources
Expression of CysLT2 receptors in asthma lung, and their possible role in bronchoconstriction
Allergology International, 2015 Background: The expression and functional role of CysLT2 receptors in asthma have not been clarified. In this study, we evaluated CysLT2 receptors expression, and effects of CysLT2-and CysLT1/2-receptor antagonists on antigen-induced bronchoconstriction ...
Tomohiko Sekioka +7 more
doaj +1 more source
Designs of Antigen Structure and Composition for Improved Protein-Based Vaccine Efficacy
Frontiers in Immunology, 2020 Today, vaccinologists have come to understand that the hallmark of any protective immune response is the antigen. However, it is not the whole antigen that dictates the immune response, but rather the various parts comprising the whole that are capable ...
Kyle Saylor +5 more
doaj +1 more source
Tolerogenic Immunotherapy: Targeting DC Surface Receptors to Induce Antigen-Specific Tolerance
Frontiers in Immunology, 2021 Dendritic cells (DCs) are well-established as major players in the regulation of immune responses. They either induce inflammatory or tolerogenic responses, depending on the DC-subtype and stimuli they receive from the local environment.
Charlotte Castenmiller +5 more
doaj +1 more source
F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj +1 more source
Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine
Frontiers in Immunology, 2023 Advances in antigen targeting in veterinary medicine have gained traction over the years as an alternative approach for diseases that remain a challenge for traditional vaccines.
Edgar Alonso Melgoza-González +2 more
doaj +1 more source
F1000Research, 2014 The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T
Klaus Ley
doaj +1 more source
Generation of Chimeric Antigen Receptors against Tetraspanin 7
Cells, 2023 Adoptive transfer of antigen-specific regulatory T cells (Tregs) has shown promising results in the treatment of autoimmune diseases; however, the use of polyspecific Tregs has limited effects.
Tom Pieper +10 more
doaj +1 more source