Results 51 to 60 of about 691 (170)

CDR3 Variants of the TXB2 Shuttle with Increased TfR1 Association Rate and Enhanced Brain Penetration

Pharmaceutics, 2023
Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy.
Pawel Stocki, Jaroslaw Szary, Mykhaylo Demydchuk, Leandra Northall, Charlotte L. M. Rasmussen, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Shu-Fen Coker, Torben Moos, Frank S. Walsh, J. Lynn Rutkowski   +11 more
doaj   +1 more source

Shape Tuning of Magnetite Nanoparticles Obtained by Hydrothermal Synthesis: Effect of Temperature

Journal of Nanomaterials, Volume 2019, Issue 1, 2019., 2019
In this work, we present a simple and efficient method for pure phase magnetite (Fe3O4) nanoparticle synthesis. The phase structure, particle shape, and size of the samples were characterized by Raman spectroscopy (Rm), X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy‐dispersive X‐ray (EDS), and transmission electron microscopy (TEM).
Nayely Torres-Gómez, Osvaldo Nava, Liliana Argueta-Figueroa, René García-Contreras, Armando Baeza-Barrera, Alfredo R. Vilchis-Nestor, Paulo Cesar Morais   +6 more
wiley   +1 more source

Marine-derived microbes and molecules for drug discovery

Inflammation and Regeneration, 2022
Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many islands and is surrounded by seas, straits, gulfs, bays, and coves, giving it the second longest coastline ...
Yoshimasa Tanaka, Megumi Nishikawa, Kaho Kamisaki, Saki Hachiya, Moeka Nakamura, Takahiro Kuwazuru, Susumu Tanimura, Kiyoshi Soyano, Kohsuke Takeda   +8 more
doaj   +1 more source

Plasmonic Sensing of Aqueous‐Divalent Metal Ions by Biogenic Gold Nanoparticles

Journal of Nanomaterials, Volume 2019, Issue 1, 2019., 2019
The chemical interaction between biogenic gold nanoparticles (AuNPs) and several metal (II) ions can be regarded as a practical, twofold, colorimetric, and plasmon resonance sensing method for the recognition of some divalent metal ions in aqueous solutions. The green synthesized AuNPs, using Camellia sinensis as a reducing agent, were characterized by
Luisa E. Silva-De Hoyos, Victor Sánchez-Mendieta, Alfredo R. Vilchis-Nestor, Miguel A. Camacho-López, Jésica Trujillo-Reyes, Miguel Avalos-Borja, Ilaria Fratoddi   +6 more
wiley   +1 more source

Anti‐ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen‐Induced Mouse Model of Rheumatoid Arthritis

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The interaction of ICOS with its sole ligand, the inducible T cell costimulatory ligand (ICOSL; also known as B7‐related protein‐1 ...
Ronan O’Dwyer, Marina Kovaleva, Jiquan Zhang, John Steven, Emma Cummins, Deborah Luxenberg, Alfredo Darmanin-Sheehan, Miguel F. Carvalho, Matthew Whitters, Kenneth Saunders, Caroline J. Barelle, Ilaria Roato   +11 more
wiley   +1 more source

Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders [PDF]

, 2017
Anti-idiotypic binders which specifically recognize the variable region of monoclonal antibodies have proven to be robust tools for pharmacokinetic studies of antibody therapeutics and for the development of cancer vaccines. In the present investigation,
Schröter, Christian, Martin Empting, Stefan Zielonka, Desislava Yanakieva, Sellmann, Carolin, Stefan Becker, Grzeschik, Julius, Zielonka, Stefan, Kolmar, Harald, Doreen Könning, Harald Kolmar, Empting, Martin, Becker, Stefan, Christian Schröter, Stephan Dickgießer, Könning, Doreen, Rhiel, Laura, Carolin Sellmann, Laura Rhiel, Julius Grzeschik, Dickgießer, Stephan, Yanakieva, Desislava, Pirzer, Thomas, Thomas Pirzer   +23 more
core   +1 more source

Irregular visits in longitudinal studies: Comparing inverse intensity of visit weighting and imputation in a causal analysis of antidepressant therapeutic treatment

Canadian Journal of Statistics, EarlyView.
Abstract Irregular observation times are common in longitudinal observational studies and can affect causal inferences. We use data from electronic health records of Kaiser Permanente Washington patients in the United States who initiated an antidepressant medication between 2008 and 2018, with a confirming diagnosis of depression. We are interested in
Janie Coulombe, Erica E. M. Moodie, Susan M. Shortreed   +2 more
wiley   +1 more source

Escherichia coli surface display for the selection of nanobodies

Microbial Biotechnology, Volume 10, Issue 6, Page 1468-1484, November 2017., 2017
Libraries of VHH genes encoding nanobodies have been traditionally cloned in phage display or yeast display systems. This review briefly describes these conventional approaches and focuses on the distinct properties of an E. coli display system developed in our laboratory, which combines the benefits of both phage display and yeast display systems ...
Valencio Salema, Luis Ángel Fernández
wiley   +1 more source

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development

Frontiers in Immunology, 2017
The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics.
Obinna C. Ubah, John Steven, Marina Kovaleva, Laura Ferguson, Charlotte Barelle, Andrew J. R. Porter, Andrew J. R. Porter, Caroline J. Barelle   +7 more
doaj   +1 more source

AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved, Jurij Lah, Goran Miličić, San Hadži   +3 more
wiley   +1 more source