Results 51 to 60 of about 1,385 (169)

Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein. [PDF]

Int J Mol Sci, 2022
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is the major target for antibody therapeutics. Shark-derived variable domains of new antigen receptors (VNARs) are the smallest antibody fragments with flexible paratopes that can recognize protein motifs inaccessible to classical antibodies. This study reported four VNARs binders (JM-2,
Chen YL, Lin JJ, Ma H, Zhong N, Xie XX, Yang Y, Zheng P, Zhang LJ, Jin T, Cao MJ.   +9 more
europepmc   +3 more sources

Shark Antibody Variable Domains Rigidify Upon Affinity Maturation—Understanding the Potential of Shark Immunoglobulins as Therapeutics

Frontiers in Molecular Biosciences, 2021
Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system.
Monica L. Fernández-Quintero, Clarissa A. Seidler, Patrick K. Quoika, Klaus R. Liedl   +3 more
doaj   +1 more source

VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins [PDF]

, 2015
Peer reviewedPublisher ...
Clem, Flajnik, Makrides, Marchalonis, Müller   +4 more
core   +3 more sources

Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]

, 2014
Peer reviewedPublisher ...
Barelle, Caroline, Empting, Martin, Grzeschik, Julius, Kolmar, Harald, Könning, Doreen, Zielonka, Stefan   +5 more
core   +1 more source

Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents [PDF]

, 2021
Funding This work was supported by the Industrial Biotechnology Innovation Centre, and Merck KGaA. Acknowledgements The authors would like to thank Iris Willenbücher and Kerstin Hallstein for the BIAcore™ analysis and Nadine Barron for the bio-layer ...
Barelle, Caroline J, Becker, Stefan, Buschhaus, Magdalena J, Porter, Andrew J   +3 more
core   +1 more source

Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications

Cells, 2021
Shark is a cartilaginous fish that produces new antigen receptor (IgNAR) antibodies. This antibody is identified with a similar human heavy chain but dissimilar sequences.
Salma Nassor Juma, Xiaoxia Gong, Sujie Hu, Zhengbing Lv, Jianzhong Shao, Lili Liu, Guiqian Chen   +6 more
doaj   +1 more source

A Single-Domain VNAR Nanobody Binds with High-Affinity and Selectivity to the Heparin Pentasaccharide Fondaparinux. [PDF]

Int J Mol Sci
Glycosaminoglycans (GAGs) are key ligands for proteins involved in physiological and pathological processes. Specific GAG-binding patterns are rarely identified, with the heparin pentasaccharide as an Antithrombin-III ligand being the best characterized.
Gschwandtner M, Derler R, Talker E, Trojacher C, Gubensäk N, Becker W, Gerlza T, Klaus Z, Stocki P, Walsh FS, Rutkowski JL, Kungl A.   +11 more
europepmc   +3 more sources

Analysis of the binding loops configuration and surface adaptation of different crystallized single‐domain antibodies in response to various antigens [PDF]

, 2017
Monoclonal antibodies have revolutionized the biomedical field through their ubiquitous utilization in different diagnostics and therapeutic applications.
Al Qaraghuli, Al-Lazikani, Almagro, Alvarez-Rueda, Anderson, Barelle, Barelle, Berman, Chames, Chothia, Chothia, Chothia, Collis, De Genst, De Genst, De Genst, De Genst, Decanniere, Decanniere, Desmyter, Desmyter, Diaz, Diaz, Ditlev, Dooley, Dooley, Doyle, Doyle, Edelman, Edelman, Fanning, Fennell, Flajnik, Greenberg, Griffin, Hall, Harmsen, Janin, Jespers, Johnson, Kabat, Kim, Kobayashi, Kontermann, Kovalenko, Ladenson, Lee, Lefranc, Lesk, Marco, Marsh, Maynard, McDonald, Miller, Muyldermans, Muyldermans, Müller, Müller, Nguyen, Nguyen-Duc, Nuttall, Olichon, Park, Porter, Raghunathan, Richards, Richards, Roux, Ruiz, Ryle, Sanner, Sheedy, Smith, Smith-Gill, Spinelli, Spinelli, Stanfield, Stanfield, Streltsov, Streltsov, Sundberg, Tanaka, Tanaka, Trott, Tuñón, Vidarsson, Vincke, Vu, Ward, Wesolowski, Wu, Yau, Zemlin, Zielonka   +93 more
core   +1 more source

Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders [PDF]

Scientific Reports, 2017
AbstractAnti-idiotypic binders which specifically recognize the variable region of monoclonal antibodies have proven to be robust tools for pharmacokinetic studies of antibody therapeutics and for the development of cancer vaccines. In the present investigation, we focused on the identification of anti-idiotypic, shark-derived IgNAR antibody variable ...
Doreen Könning, Laura Rhiel, Martin Empting, Julius Grzeschik, Carolin Sellmann, Christian Schröter, Stefan Zielonka, Stephan Dickgießer, Thomas Pirzer, Desislava Yanakieva, Stefan Becker, Harald Kolmar   +11 more
openaire   +3 more sources

Valley filtering effect of phonons in graphene with a grain boundary [PDF]

, 2019
Due to their possibility to encode information and realize low-energy-consumption quantum devices, control and manipulation of the valley degree of freedom have been widely studied in electronic systems.
Chen, Xiaobin, Guo, Hong, Wang, Jian, Xu, Yong   +3 more
core   +2 more sources