Results 61 to 70 of about 1,385 (169)

A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix [PDF]

, 2016
Inhibition of protein kinases using ATP-competitive compounds is an important strategy in drug discovery. In contrast, the allosteric regulation of kinases through the disruption of protein-protein interactions has not been widely adopted, despite the ...
Andrew G. Jamieson, Cooper A., Patrick J. McIntyre, Richard Bayliss, Tito Akindele, Yana K. Rennie   +5 more
core   +2 more sources

Enhancing the Transdermal Delivery of ‘Next Generation’ Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study [PDF]

, 2022
Heavy chain only binding proteins, such as variable new antigen receptors (VNARs), have emerged as an alternative to the highly successful therapeutic monoclonal antibodies (mAb).
Barelle, C., Donnelly, R.F., Hutton, A.R.J., Ubah, O.   +3 more
core   +1 more source

Isolation and characterization of malaria PfHRP2 specific VNAR antibody fragments from immunized shark phage display library

Malaria Journal, 2018
Background Malaria rapid diagnostic tests (RDTs) represent an important antibody based immunoassay platform. Unfortunately, conventional monoclonal antibodies are subject to degradation shortening shelf lives of RDTs. The variable region of the receptor (
Chiuan Herng Leow, Katja Fischer, Chiuan Yee Leow, Katleen Braet, Qin Cheng, James McCarthy   +5 more
doaj   +1 more source

Shape Tuning of Magnetite Nanoparticles Obtained by Hydrothermal Synthesis: Effect of Temperature

Journal of Nanomaterials, Volume 2019, Issue 1, 2019., 2019
In this work, we present a simple and efficient method for pure phase magnetite (Fe3O4) nanoparticle synthesis. The phase structure, particle shape, and size of the samples were characterized by Raman spectroscopy (Rm), X‐ray diffraction (XRD), scanning electron microscopy (SEM), energy‐dispersive X‐ray (EDS), and transmission electron microscopy (TEM).
Nayely Torres-Gómez, Osvaldo Nava, Liliana Argueta-Figueroa, René García-Contreras, Armando Baeza-Barrera, Alfredo R. Vilchis-Nestor, Paulo Cesar Morais   +6 more
wiley   +1 more source

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors [PDF]

, 2016
Myc family proteins promote cancer by inducing widespread changes in gene expression. Their rapid turn-over by the ubiquitin-proteasome pathway is regulated through phosphorylation of Myc Box I and ubiquitination by SCFFbxw7.
Bayliss, R, Burgess, S, Carstensen, A, Chesler, L, Eilers, M, Poon, E, Richards, MW   +6 more
core   +2 more sources

Plasmonic Sensing of Aqueous‐Divalent Metal Ions by Biogenic Gold Nanoparticles

Journal of Nanomaterials, Volume 2019, Issue 1, 2019., 2019
The chemical interaction between biogenic gold nanoparticles (AuNPs) and several metal (II) ions can be regarded as a practical, twofold, colorimetric, and plasmon resonance sensing method for the recognition of some divalent metal ions in aqueous solutions. The green synthesized AuNPs, using Camellia sinensis as a reducing agent, were characterized by
Luisa E. Silva-De Hoyos, Victor Sánchez-Mendieta, Alfredo R. Vilchis-Nestor, Miguel A. Camacho-López, Jésica Trujillo-Reyes, Miguel Avalos-Borja, Ilaria Fratoddi   +6 more
wiley   +1 more source

Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis

Frontiers in Immunology, 2017
Induced costimulatory ligand (ICOSL) plays an important role in the activation of T cells through its interaction with the inducible costimulator, ICOS. Suppression of full T cell activation can be achieved by blocking this interaction and has been shown
Marina Kovaleva, Katherine Johnson, John Steven, Caroline J. Barelle, Andrew Porter, Andrew Porter   +5 more
doaj   +1 more source

Anti‐ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen‐Induced Mouse Model of Rheumatoid Arthritis

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The interaction of ICOS with its sole ligand, the inducible T cell costimulatory ligand (ICOSL; also known as B7‐related protein‐1 ...
Ronan O’Dwyer, Marina Kovaleva, Jiquan Zhang, John Steven, Emma Cummins, Deborah Luxenberg, Alfredo Darmanin-Sheehan, Miguel F. Carvalho, Matthew Whitters, Kenneth Saunders, Caroline J. Barelle, Ilaria Roato   +11 more
wiley   +1 more source

Escherichia coli surface display for the selection of nanobodies

Microbial Biotechnology, Volume 10, Issue 6, Page 1468-1484, November 2017., 2017
Libraries of VHH genes encoding nanobodies have been traditionally cloned in phage display or yeast display systems. This review briefly describes these conventional approaches and focuses on the distinct properties of an E. coli display system developed in our laboratory, which combines the benefits of both phage display and yeast display systems ...
Valencio Salema, Luis Ángel Fernández
wiley   +1 more source

Marine-derived microbes and molecules for drug discovery

Inflammation and Regeneration, 2022
Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many islands and is surrounded by seas, straits, gulfs, bays, and coves, giving it the second longest coastline ...
Yoshimasa Tanaka, Megumi Nishikawa, Kaho Kamisaki, Saki Hachiya, Moeka Nakamura, Takahiro Kuwazuru, Susumu Tanimura, Kiyoshi Soyano, Kohsuke Takeda   +8 more
doaj   +1 more source