Results 81 to 90 of about 691 (170)
, 2010 El síndrome metabólico (SM) es un concepto clínico que se compone por la asociación de varias enfermedades como obesidad, resistencia a insulina, diabetes mellitus tipo 2, aterosclerosis, entre otras, las cuales se encuentran vinculadas ...
Carmen Elvira Vargas Peralta
core
Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance [PDF]
, 2019 Herein we report the construction of a nanoparticle-based drug delivery system which targets a key regulator in tumour angiogenesis. We exploit a Variable New Antigen Receptor (VNAR) domain, conjugated using site-specific chemistry, to direct poly lactic
Steven, J +8 more
core +2 more sources
, 2019 Los fragmentos de anticuerpos de dominio sencillo vNAR, derivados de tiburones, presentan características especiales en comparación con las moléculas convencionales de anticuerpos, como tamaño pequeño (12-15 kDa), estabilidad térmica y química y buena ...
OLIVIA CABANILLAS BERNAL
core
, 2014 En este trabajo se clonó y expresó en Pichia pastoris un anticuerpo vNAR neutralizante de la citocina TGF-β, obtenido de una biblioteca no inmune a partir del tiburón Heterodontus francisci. Se ha demostrado que los anticuerpos de dominio sencillo (vNAR)
Constanza Estefania Martínez Olivares
core
In vitro analysis of VNAR-bioconjugated nanogels (N3).
A) ELISA of VNAR expression. On the horizontal axis: B (blank, Svelty milk 8%-PBS), N3 C- (nanogel without VNAR), C+ (CV043, 175 μg/mL), 1h (sample taken at hour 1 of the coupling reaction), 4h (sample taken at hour 4 of the coupling reaction), 8h (final
Jahaziel Gasperin-Bulbarela (12936644) +6 more
core +1 more source
Development Of Dengue Immunodiagnostic Assay By Targeting Denv Type 2 Ns1 Using Shark Single Domain Vnar Antibody [PDF]
Denv infection diagnosis requires early and rapid detection which is accurate and specific to provide effective treatment for the patients. However, problems such as limitations of rapid diagnostic test, antibody instability, cross-reaction among denv ...
Kok, Boon Hui
core +1 more source
Efficient Construction and Effective Screening of Synthetic Domain Antibody Libraries
Methods and Protocols, 2019 Phage display is a powerful technique for drug discovery in biomedical research in particular for antibody libraries. But, several technical challenges are associated with the selection process.
Arghavan Solemani Zadeh +4 more
doaj +1 more source
Obtention of type vNar antibodies wich recognizes and neutralizes scorpion venoms
, 2009 El alacranismo es un grave problema de salud pública en algunos países. Se presenta en muchas regiones en el mundo como en el Norte y Sur de África, India, Medio Oriente, Turquía, Francia, España, Mongolia, China, Asia Central y en América, en donde ...
Diego Alonso Montoya Bonillas
core
The shark strikes twice: Generation of Mono- and Bispecific High-Affinity vNAR Antibody Domains via Step-Wise Affinity Maturation [PDF]
, 2015 The aim of the work presented herein was the generation of high-affinity shark vNAR domains targeting different disease related antigens. For this, the natural IgNAR V domain repertoire of the bamboo shark (Chiloscyllium plagiosum) was analyzed and in ...
Zielonka, Stefan
core
Sequences of vNAR domains used as frameworks for libraries construction.
, 2019 T1 without Cys, T20 with one Cys and TN16 with two Cys residues within its CDR3. The different regions of the vNAR are labeled. FR: Framework, CDR: complementarity-determining region, HVR: Hypervariable region. Canonical Cys are enclosed in red.
Alexandra Rucavado (32147) +5 more
core +1 more source