Results 91 to 100 of about 691 (170)
Single Domain Antibodies as New Biomarker Detectors
Diagnostics, 2017 Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for ...
Chiuan Herng Leow +5 more
doaj +1 more source
, 2008 La Bacillus anthracis causante de la infección del carbunco, debe su toxicidad a las modificaciones citosólicas que causan sus factores tóxicos: Factor Letal (FL), Factor de Edema (FE) y a la proteína que los transloca al interior de la célula, llamada ...
Omar Mendoza Porras
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Evaluation of the neutralizing capacity of TNFα by a chimeric protein designed in silico from a VNAR
, 2021 Los tratamientos anti-TNFα actuales presentan variados efectos secundarios y en algunos casos resultan ineficientes ya que se desarrolla tolerancia. En la búsqueda de tratamientos que no generen reacciones de inmunidad ni efectos secundarios, el equipo ...
Monserrat Rentería Maciel
core
Frontiers in Immunology, 2017 Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice.
John Steven +11 more
doaj +1 more source
, 2013 La araña viuda negra (Latrodectus mactans) es considerada por la OrganizaciónMundial de la Salud (OMS) de gran interés médico debido a las manifestacionesclínicas que provoca el envenenamiento de su mordedura en humanos.
Erika Elizabeth León Acosta
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, 2008 La telomerasa es una ribonucleoproteína que regula la síntesis de DNA telomérico, lo cual tiene alta relevancia para la supervivencia de la células.
Reyna Michelle Quezada Iñiguez
core
Production Of Novel Recombinant Antipfhrp2 VNAR-G1 Protein Using Escherichia Coli Bl21(DE3) Expression System [PDF]
, 2020 Malaria rapid diagnostic tests (RDTs) act as important antibody-based immunoassays for prompt malaria diagnosis. Conventional monoclonal antibodies (mAbs) are widely used in RDTs but it can be easily degraded at high ambient temperatures.
Kok, Boon Hui
core
, 2018 Additional file 1. PCR amplification of randomly selected plaques from the VNAR domains primary library using T7SelectUP (For) and T7SelectDOWN (Rev) sequencing primers.
Katleen Braet (5894342) +4 more
core +1 more source
Cross-reactivity evaluation of vNAR antibodies with TGFβ.
, 2019 AQ14, AQ16, VS0-4, VS1-20, FGV0-6, FGV0-31, LIV0-2 and CV0-43 were used as capture antibodies in a sandwich ELISA to evaluate their binding to TGFβ, which is the target antigen of the frameworks used for the VS0 and VS1 libraries.
Alexandra Rucavado (32147) +5 more
core +1 more source
Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain
The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects.
Oleksy, Arkadiusz +6 more
core