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In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties
2019VNAR domains are the binding regions of new antigen receptor proteins (IgNAR) which are unique to sharks, skates, and rays (Elasmobranchii). Individual VNAR domains can bind antigens independently and are the smallest reported adaptive immune recognition entities in the vertebrate kingdom.
John, Steven +6 more
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A shark VNAR-IL-15 fusion protein that suppresses TROP2+ tumor growth
International Journal of Biological MacromoleculesInterleukin-15 (IL-15) holds great promise for cancer immunotherapy because it selectively activates cytotoxic immune cells without expanding regulatory T cells. It also has the potential to convert "cold" tumors into more immunologically active ones. However, its clinical utility is limited by systemic toxicity.
Zhongqiu, Wu +5 more
openaire +2 more sources
Biochemical Society Transactions, 2018
Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of biosimilars. Despite this success, there are still limitations associated with the use of mAbs as therapeutic molecules.
Obinna C, Ubah +6 more
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Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of biosimilars. Despite this success, there are still limitations associated with the use of mAbs as therapeutic molecules.
Obinna C, Ubah +6 more
openaire +2 more sources
High-affinity VNARs targeting human hemoglobin: Screening, stability and binding analysis
International Journal of Biological MacromoleculesHemoglobin, composed of α- and β-chains, is essential for oxygen transport and is key in diagnosing and treating gastrointestinal and blood disorders. It also aids in detecting blood contamination and estimating transfusion volumes. Immunological methods, based on antigen-antibody interactions, are distinguished by their high sensitivity and accuracy ...
Wen-Hui, Lei +9 more
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Fish & Shellfish Immunology
IgNAR exhibits significant promise in the fields of cancer and anti-virus biotherapies. Notably, the variable regions of IgNAR (VNAR) possess comparable antigen binding affinity with much smaller molecular weight (∼12 kDa) compared to IgNAR. Antigen specific VNAR screening is a changeling work, which limits its application in medicine and therapy ...
Bo Zhong +10 more
openaire +2 more sources
IgNAR exhibits significant promise in the fields of cancer and anti-virus biotherapies. Notably, the variable regions of IgNAR (VNAR) possess comparable antigen binding affinity with much smaller molecular weight (∼12 kDa) compared to IgNAR. Antigen specific VNAR screening is a changeling work, which limits its application in medicine and therapy ...
Bo Zhong +10 more
openaire +2 more sources