Results 111 to 120 of about 1,385 (169)

Development of a cationic polyethyleneimine-poly(lactic-co-glycolic acid) nanoparticle system for enhanced intracellular delivery of biologics. [PDF]

RSC Adv, 2023
Tracey SR, Smyth P, Herron UM, Burrows JF, Porter AJ, Barelle CJ, Scott CJ.   +6 more
europepmc   +1 more source

RNA mutagenesis yields highly diverse mRNA libraries for in vitro protein evolution [PDF]

, 2007
George Kopsidas, Rachael K Carman, Emma L Stutt, Anna Raicevic, Anthony S Roberts, Mary-Anne V Siomos, Nada Dobric, Luisa Pontes-Braz, Greg Coia   +8 more
core   +1 more source

Ensayos de obtención de fragmentos vNAR para la detección de Coccidioides spp.

, 2018
Valley Fever or Coccidioidomycosis (CM) is a pulmonary disease caused by the fungus Coccidioides spp. Soil disturbance by humans, animals or climate leads to Coccidioides spores dispersion in the air and spores inhalation by people. The spores form spherules inside a host that grow up creating endospores capable of disease dissemination and new ...
openaire   +2 more sources

Obtención de anticuerpos tipo vNAR anti-PCSK9 de tiburón Heterodontus francisci

, 2019
La hipercolesterolemia es la causa principal de enfermedades aterogénicas que concluyen en la reducción de la calidad de vida o la muerte en una gran población a nivel mundial. A consecuencia de los problemas de salud que causan los altos niveles de colesterol en sangre, se ha puesto especial énfasis en el desarrollo de nuevas terapias dirigidas a ...
openaire   +1 more source

Construction and application of a multifunctional CHO cell platform utilizing Cre/lox and Dre/rox site-specific recombination systems. [PDF]

Front Bioeng Biotechnol, 2023
Zhang C, Chang F, Miao H, Fu Y, Tong X, Feng Y, Zheng W, Ma X.   +7 more
europepmc   +1 more source

High efficiency blood-brain barrier transport using a VNAR targeting the Transferrin Receptor 1 (TfR1)

, 2019
ABSTRACT Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of central nervous system (CNS) biologics. We established a functional selection method for BBB-penetrating VNAR antibodies from a synthetic phage library.
Stocki, Pawel, Szary, Jaroslaw M, Jacobsen, Charlotte LM, Demydchuk, Mykhaylo, Northall, Leandra, Moos, Torben, Walsh, Frank S, Rutkowski, J Lynn   +7 more
openaire   +1 more source

Chimeric Peptides from Californiconus californicus and Heterodontus francisci with Antigen-Binding Capacity: A Conotoxin Scaffold to Create Non-Natural Antibodies (NoNaBodies). [PDF]

Toxins (Basel), 2023
Dueñas S, Escalante T, Gasperin-Bulbarela J, Bernáldez-Sarabia J, Cervantes-Luévano K, Jiménez S, Sánchez-Campos N, Cabanillas-Bernal O, Valdovinos-Navarro BJ, Álvarez-Lee A, De León-Nava MA, Licea-Navarro AF.   +11 more
europepmc   +1 more source

A high diversity naïve variable new antigen receptor, vNAR, phage library for rapid nanobody discovery across diverse antigens. [PDF]

J Biol Chem
Kumar V, Jangid K, Santhosh B, Dixit R, Yadav U, Verma S, Rout A, Surya S, Das M, Gupta R, Saroj A, Madhukalya R, Gupta M, Kalra M, Iqbal H, Kumar D, Sinha S, Tomar S, Kumar P, Kumar R.   +19 more
europepmc   +1 more source

Humanization of the Shark V_NAR Single Domain Antibody Using CDR Grafting. [PDF]

Curr Protoc, 2023
Zhang YF, Sun Y, Hong J, Ho M.
europepmc   +1 more source

Efecto de un VNAR anti-VEGF165 en el tratamiento del cáncer

, 2018
Los VNARs se han probado como nuevos entes terapéuticos, basados en su estabilidad, capacidad de unión y penetración en los tejidos. El V13, un VNAR que reconoce al VEGF, se utilizó como molécula parental en la cual se insertaron cambios de aminoácidos in silico. Se generaron cinco mutantes de VNAR in silico para modificar el reconocimiento por el VEGF.
openaire   +1 more source