Results 131 to 140 of about 691 (170)
Cytoplasmic and periplasmic expression of recombinant shark VNAR antibody in Escherichia coli
Preparative Biochemistry and Biotechnology, 2019 Shark variable new antigen receptors (VNARs) are known to possess excellent heat-stability, and the long complementarity determining region 3 (CDR3) has permitted it to penetrate into the cleft region of antigens.
James S McCarthy +2 more
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Exploring shark VNAR antibody against infectious diseases using phage display technology
Fish and Shellfish Immunology, 2023Antibody with high affinity and specificity to antigen has widely used as a tool to combat various diseases. The variable domain of immunoglobulin new antigen receptor (VNAR) naturally found in shark contains autonomous function as single-domain antibody.
Chiuan Yee Leow +2 more
exaly +3 more sources
Single domain shark VNAR antibodies neutralize SARS-CoV-2 infection in vitro. [PDF]
FASEB Journal, 2021 Abstract Single domain shark VNAR antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodies selected against the SARS-CoV-2 spike protein derived from
Andreas J Kungl +2 more
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FASEB Journal, 2021 Transfer across the blood-brain barrier (BBB) remains a significant hurdle for the development of biopharmaceuticals with therapeutic effects within the central nervous system. We established a functional selection method to identify high affinity single
Torben Moos +2 more
exaly +2 more sources
International Journal of Molecular Sciences, 2022 Severe Acute Respiratory Syndrome Coronavirus 2 is the causal pathogen of coronavirus disease 2019 (COVID-19). The emergence of new variants with different mutational patterns has limited the therapeutic options available and complicated the development ...
Alexei Licea-Navarro +2 more
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Construction of Semisynthetic Shark vNAR Yeast Surface Display Antibody Libraries
2023The adaptive immune system of sharks comprises a unique heavy chain-only antibody isotype, termed immunoglobulin new antigen receptor (IgNAR), in which antigen binding is mediated by a single variable domain, referred to as vNAR. In recent years, efforts were made to harness these domains for biomedical and biotechnological applications particularly ...
Harald, Kolmar +4 more
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Preparation of Immune and Synthetic VNAR Libraries as Sources of High-Affinity Binders
2022The shark-derived autonomous variable antibody domains known as VNARs are attractive tools for therapeutic and diagnostic applications due to their favorable properties like small size (approximately 12 kDa), high thermal and chemical stability, and good tissue penetration.
Jahaziel, Gasperin-Bulbarela +3 more
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Fish & Shellfish Immunology, 2023
The development of recombinant antibody fragments as promising alternatives to full-length immunoglobulins offers vast opportunities for biomedicine. Antibody fragments have important advantages compared with conventional monoclonal antibodies that make them attractive for the biotech industry: superior stability and solubility, reduced immunogenicity,
Karen, Manoutcharian, Goar, Gevorkian
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The development of recombinant antibody fragments as promising alternatives to full-length immunoglobulins offers vast opportunities for biomedicine. Antibody fragments have important advantages compared with conventional monoclonal antibodies that make them attractive for the biotech industry: superior stability and solubility, reduced immunogenicity,
Karen, Manoutcharian, Goar, Gevorkian
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Overview and Discovery of IgNARs and Generation of VNARs
2012Immunoglobulin new antigen receptors (IgNARs) from sharks are a distinct class of immune receptors, consisting of homodimers with no associated light chains. Antigen binding is encapsulated within single VNAR immunoglobulin domains of 13-14 kDa in size.
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VNAR single-domain antibodies specific for BAFF inhibit B cell development by molecular mimicry
Molecular Immunology, 2016 B cell-activating factor (BAFF) plays a dominant role in the B cell homeostasis. However, excessive BAFF promotes the development of autoreactive B-cells and several antibodies have been developed to block its activity.
Gareth Williams +2 more
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