Results 141 to 150 of about 1,385 (169)
Nanomaterial-Mediated Electrochemical and Optical Biosensors and Their Application in Tumour Marker Detection. [PDF]
Sensors (Basel)Wang X, Hei J, Zhao T, Liu X, Huang Y.
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Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies. [PDF]
Genes DisJuma SN +8 more
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Single domain shark VNAR antibodies neutralize SARS‐CoV‐2 infection in vitro [PDF]
FASEB Journal, 2021 AbstractSingle domain shark VNAR antibodies can offer a viable alternative to conventional Ig-based monoclonal antibodies in treating COVID-19 disease during the current pandemic. Here we report the identification of neutralizing single domain VNAR antibodies selected against the SARS-CoV-2 spike protein derived from the Wuhan variant using phage ...
Tanja Gerlza +2 more
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Exploring shark VNAR antibody against infectious diseases using phage display technology
Fish and Shellfish Immunology, 2023Antibody with high affinity and specificity to antigen has widely used as a tool to combat various diseases. The variable domain of immunoglobulin new antigen receptor (VNAR) naturally found in shark contains autonomous function as single-domain antibody.
Hui Ting Lim +2 more
exaly +3 more sources
International Journal of Biological Macromolecules, 2020 Conventional monoclonal antibodies (mAbs) have been widely used in research and diagnostic applications due to their high affinity and specificity. However, multiple limitations, such as large size, complex structure and sensitivity to extreme ambient temperature potentially weaken the performance of mAbs in certain applications.
Chiuan Yee Leow +2 more
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Construction of Semisynthetic Shark vNAR Yeast Surface Display Antibody Libraries
2023The adaptive immune system of sharks comprises a unique heavy chain-only antibody isotype, termed immunoglobulin new antigen receptor (IgNAR), in which antigen binding is mediated by a single variable domain, referred to as vNAR. In recent years, efforts were made to harness these domains for biomedical and biotechnological applications particularly ...
Harald, Kolmar +4 more
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Fish & Shellfish Immunology, 2023
The development of recombinant antibody fragments as promising alternatives to full-length immunoglobulins offers vast opportunities for biomedicine. Antibody fragments have important advantages compared with conventional monoclonal antibodies that make them attractive for the biotech industry: superior stability and solubility, reduced immunogenicity,
Karen, Manoutcharian, Goar, Gevorkian
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The development of recombinant antibody fragments as promising alternatives to full-length immunoglobulins offers vast opportunities for biomedicine. Antibody fragments have important advantages compared with conventional monoclonal antibodies that make them attractive for the biotech industry: superior stability and solubility, reduced immunogenicity,
Karen, Manoutcharian, Goar, Gevorkian
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VNAR single-domain antibodies specific for BAFF inhibit B cell development by molecular mimicry [PDF]
Molecular Immunology, 2016 B cell-activating factor (BAFF) plays a dominant role in the B cell homeostasis. However, excessive BAFF promotes the development of autoreactive B-cells and several antibodies have been developed to block its activity. Bispecific antibodies with added functionality represent the next wave of biologics that may be more effective in the treatment of ...
Gareth Williams, Martin F Flajnik
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Preparation of Immune and Synthetic VNAR Libraries as Sources of High-Affinity Binders
2022The shark-derived autonomous variable antibody domains known as VNARs are attractive tools for therapeutic and diagnostic applications due to their favorable properties like small size (approximately 12 kDa), high thermal and chemical stability, and good tissue penetration.
Jahaziel, Gasperin-Bulbarela +3 more
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