Results 141 to 150 of about 691 (170)

Generation of VNAR Libraries from Immunized Sharks and Selection of Target-Specific Clones

2021
Cartilaginous fishes (sharks, skates, rays, and chimeras) are the most phylogenetically distant lineage relative to mammals in which somatically rearranging immunoglobulins (Igs or antibodies) have also been found. Alongside their conventional (heavy-light chain) isotypes, IgM and IgW, sharks produce the novel isotype, IgNAR, a heavy-chain homodimer ...
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In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties

2019
VNAR domains are the binding regions of new antigen receptor proteins (IgNAR) which are unique to sharks, skates, and rays (Elasmobranchii). Individual VNAR domains can bind antigens independently and are the smallest reported adaptive immune recognition entities in the vertebrate kingdom.
John, Steven, Obinna C, Ubah, Magdalena, Buschhaus, Marina, Kovaleva, Laura, Ferguson, Andrew J, Porter, Caroline J, Barelle   +6 more
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Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability

Biochemical Society Transactions, 2018
Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of biosimilars. Despite this success, there are still limitations associated with the use of mAbs as therapeutic molecules.
Obinna C, Ubah, Magdalena J, Buschhaus, Laura, Ferguson, Marina, Kovaleva, John, Steven, Andrew J, Porter, Caroline J, Barelle   +6 more
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High-affinity VNARs targeting human hemoglobin: Screening, stability and binding analysis

International Journal of Biological Macromolecules
Hemoglobin, composed of α- and β-chains, is essential for oxygen transport and is key in diagnosing and treating gastrointestinal and blood disorders. It also aids in detecting blood contamination and estimating transfusion volumes. Immunological methods, based on antigen-antibody interactions, are distinguished by their high sensitivity and accuracy ...
Wen-Hui, Lei, Zu-Ying, Liu, Xiao-Xiao, Xie, Ning, Zhong, Ling-Jing, Zhang, Min-Jie, Cao, Duanquan, Lin, Tengchuan, Jin, Changgong, Zhang, Yu-Lei, Chen   +9 more
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A shark VNAR-IL-15 fusion protein that suppresses TROP2+ tumor growth

International Journal of Biological Macromolecules
Interleukin-15 (IL-15) holds great promise for cancer immunotherapy because it selectively activates cytotoxic immune cells without expanding regulatory T cells. It also has the potential to convert "cold" tumors into more immunologically active ones. However, its clinical utility is limited by systemic toxicity.
Zhongqiu, Wu, Hao, Li, Yanqing, Wang, Ling, Lu, Yuchao, Gu, Ming-Wei, Wang   +5 more
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Characterization and humanization of VNARs targeting human serum albumin from the whitespotted bamboo shark (Chiloscyllium plagiosum)

International Journal of Biological Macromolecules
The Shark-derived immunoglobulin new antigen receptors (IgNARs) have gained increasing attention for their high solubility, exceptional thermal stability, and intricate sequence variation. In this study, we immunized whitespotted bamboo shark (Chiloscyllium plagiosum) to create phage display library of variable domains of IgNAR (VNARs) for screening ...
Weijie, Li, Mingliang, Chen, Tao, Wang, Xin, Feng, Xierui, Jiang, Xiaoning, Dong, Huan, Zhang, Xixiang, Tang, Rui, Tian, Yongyou, Zhang, Zengpeng, Li   +10 more
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Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum)

Marine Drugs, 2022
Mingliang Chen, Weiwei Xue, Shoukai kang
exaly  

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Frontiers in Marine Science, 2023
Jianqing Wen
exaly  

SHARK VNARS FOR TREATING COVID-19

2022
GAUHAR AZIZ, PRIVEZENTZEV CYRIL V, STOCKI PAWEL, RUTKOWSKI JULIA LYNN   +3 more
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PERSONALIZED VNAR-BASED CHIMERIC ANTIGEN RECEPTORS (VNAR-CAR) FOR THE TREATMENT OF CLONAL B-AND T CELL MALIGNANCIES, AND METHODS FOR PRODUCING VNAR-CARS

2023
ULLRICH EVELYN, WENDEL PHILIPP, WELS WINFRIED, OBEROI PRANAV, KOLMAR HARALD, MACCARÓN PALACIOS ARTURO, HABERMANN JAN, SCHOENFELD KATRIN   +7 more
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