Results 151 to 160 of about 737 (163)

Of splice and men: what does the distribution of IKAP mRNA in the rat tell us about the pathogenesis of familial dysautonomia?

Brain Research, 2003
Familial dysautonomia (FD) is the best-known and most common member of a group of congenital sensory/autonomic neuropathies characterized by widespread sensory and variable autonomic dysfunction. As opposed to the sensory/motor neuropathies, little is known about the causes of neuronal dysfunction and loss in the sensory/autonomic neuropathies.
Susan Slaugenhaupt, Eva Mezey, Ildikó Szalayova   +2 more
exaly   +3 more sources

Identification of neuronal autophagy regulators: Combined use of iKAP and THANATOS

Movement Disorders, 2018
Junxia Xie
exaly   +3 more sources

IKAP is a scaffold protein of the IκB kinase complex

Nature, 1998
The transcription factor NF-kappaB coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappaB is activated by phsophorylation of its inhibitory subunit, IkappaB-alpha, on serine residues 32 and 36 by cytokine ...
L, Cohen, W J, Henzel, P A, Baeuerle
openaire   +2 more sources

The effect of tailored nursing interventions based on the IKAP model on the discharge readiness of the spouses or children of breast cancer patients: a randomized controlled trial [PDF]

Supportive Care in Cancer
Wang L, Zhang Q, Li J, Lu C, Zhong J, Liu Y, Ji M, Yi H, Huang F, Huang C, Lin Y.   +10 more
exaly   +2 more sources

Effects of IKAP Health Education and Exercise Therapy on Clinical Outcomes in Hypertensive Intracerebral Hemorrhage

Journal of Visualized Experiments
The study aims to investigate the effects of the Information-Knowledge-Attitude-Practice (IKAP) health education combined with exercise therapy model on electrolyte homeostasis, liver function, and kidney function in patients with hypertensive intracerebral hemorrhage (HICH), and to construct a multidimensional biomarker-based multiple organ ...
Chengjuan, Zhao, Leiting, Wan
openaire   +2 more sources

Effects of Hypoxia on Adipose Tissue Expression of NFκB, IκBα, IKKγ and IKAP in Patients with Chronic Obstructive Pulmonary Disease

Cell Biochemistry and Biophysics, 2012
Recently we observed increased adipose tissue (AT) expression of CD40-related signaling proteins but no activation of tumor necrosis factor-α or CD68 in patients with chronic sustained hypoxia resulting from chronic obstructive pulmonary disease (COPD).
R, Tkacova, J, Ukropec, P, Skyba, B, Ukropcova, P, Pobeha, T, Kurdiova, P, Joppa, I, Klimes, I, Tkac, D, Gasperikova   +9 more
openaire   +2 more sources

IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination

Human Molecular Genetics, 2007
The gene affected in the congenital neuropathy familial dysautonomia (FD) is IKBKAP that codes for the IKAP/hELP1 protein. Several different functions have been suggested for this protein, but none of them have been verified in vivo or shown to have some link with the FD phenotype.
David, Cheishvili, Channa, Maayan, Yoav, Smith, Gil, Ast, Aharon, Razin   +4 more
openaire   +2 more sources

The Impact of IKAP-Based Nursing Interventions on the Caregiving Capacity of Family Carers for Individuals with Dementia

Journal of Clinical and Nursing Research
Objective: To investigate the effect of an information-knowledge-attitude-practice (IKAP) nursing intervention on the caregiving capacity of family caregivers of elderly dementia patients. Methods: Sixty-nine family caregivers of elderly dementia patients attending the neurology outpatient clinic of a hospital between October 2024 and March 2025 were ...
Shuhui Zhao, Yao Li
openaire   +1 more source

[Molecular and cellular characterization ion of IKAP protein and the Elongator complex. Implications for familial dysautonomia].

Bulletin et memoires de l'Academie royale de medecine de Belgique, 2008
Familial dysautonomia (FD), a severe neuro-developmental and neurodegenerative genetic disorder, is caused by mutations of IKBKAP encoding a subunit of Elongator. FD patients have decreased expression of IKAP in a tissue-specific manner and consequently impaired Elongator function.
P, Close, C, Creppe, I, Cornez, M A, Chariot, A, Chariot   +4 more
openaire   +1 more source

Curative Effect of IKAP Nursing in Perioperative Nursing of Endometriosis Treated by Laparoscopic Surgery.

Alternative therapies in health and medicine
To evaluate the effectiveness of Information, Knowledge, Attitude, and Practice (IKAP) nursing in the perioperative care of endometriosis patients treated with laparoscopic surgery.A total of 100 patients with endometriosis who underwent laparoscopic surgery in our hospital from June 2020 to December 2021 were recruited and assigned to receive either ...
Jie, Liu, Xiaohong, Zhang, Fengju, Zhang, Zhifen, Wang   +3 more
openaire   +1 more source