Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults [PDF]
BMC Genomics, 2017 Background Transcriptional elongation is a generic function, but is also regulated to allow rapid transcription responses. Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following ...
Haiwang Yang +3 more
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Regulation of transcription elongation in response to osmostress. [PDF]
PLoS Genetics, 2017 Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exposed
Andrea Silva +7 more
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The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation [PDF]
AdipocyteRegulation of adipogenesis has classically been viewed through the lens of transcription initiation driven by lineage defining transcription factors.
Julian Gomez +6 more
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DNA topological regulation in RNA polymerase II transcription [PDF]
Cellular & Molecular Biology LettersRNA polymerase II (Pol II) is the main enzyme that synthesizes protein-coding messenger RNA and a subset of nonprotein coding RNA molecules based on the DNA sequences harboring genetic information in eukaryotes.
Heeyoun Bunch
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The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma [PDF]
MedCommPancreatic ductal adenocarcinoma (PDAC) remains a therapeutic challenge, and the aggressive basal‐like/mesenchymal subtype is particularly refractory to chemotherapy, underscoring the need for novel therapies.
Janine Murr +37 more
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Transcription elongation factor SII [PDF]
BioEssays, 2000 RNA chain elongation by RNA polymerase II (pol II) is a complex and regulated process which is coordinated with capping, splicing, and polyadenylation of the primary transcript. Numerous elongation factors that enable pol II to transcribe faster and/or more efficiently have been purified. SII is one such factor.
M, Wind, D, Reines
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A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2016 The elongation phase of transcription by RNA Polymerase II (Pol II) involves numerous events that are tightly coordinated, including RNA processing, histone modification, and chromatin remodeling.
Jeong H Ahn +3 more
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Functional specialization of transcription elongation factors [PDF]
The EMBO Journal, 2008 Elongation factors NusG and RfaH evolved from a common ancestor and utilize the same binding site on RNA polymerase (RNAP) to modulate transcription. However, although NusG associates with RNAP transcribing most Escherichia coli genes, RfaH regulates just a few operons containing ops, a DNA sequence that mediates RfaH recruitment. Here, we describe the
Georgiy A, Belogurov +4 more
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TRIM28 as a novel transcriptional elongation factor [PDF]
BMC Molecular Biology, 2015 TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation. TRIM28 was shown to stabilize the pausing of RNA polymerase II (Pol II) close to the transcriptional start site in many unactivated genes, permitting Pol II ...
Heeyoun Bunch, Stuart K Calderwood
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Translational repression by a transcriptional elongation factor [PDF]
Genes & Development, 1997 One of the classical positive regulators of gene expression is bacteriophage λ N protein. N regulates the transcription of early phage genes by participating in the formation of a highly processive, terminator-resistant transcription complex and thereby stimulates the expression of genes lying downstream of transcriptional terminators. Also included in
H R, Wilson +4 more
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