Regulation of transcription elongation in response to osmostress. [PDF]
PLoS Genetics, 2017 Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exposed
Andrea Silva +7 more
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LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis [PDF]
eLife, 2014 Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Xiaodan Ji +3 more
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Transcription elongation factor SII [PDF]
BioEssays, 2000 RNA chain elongation by RNA polymerase II (pol II) is a complex and regulated process which is coordinated with capping, splicing, and polyadenylation of the primary transcript. Numerous elongation factors that enable pol II to transcribe faster and/or more efficiently have been purified. SII is one such factor.
M, Wind, D, Reines
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A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans. [PDF]
PLoS Genetics, 2016 The elongation phase of transcription by RNA Polymerase II (Pol II) involves numerous events that are tightly coordinated, including RNA processing, histone modification, and chromatin remodeling.
Jeong H Ahn +3 more
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Functional specialization of transcription elongation factors [PDF]
The EMBO Journal, 2008 Elongation factors NusG and RfaH evolved from a common ancestor and utilize the same binding site on RNA polymerase (RNAP) to modulate transcription. However, although NusG associates with RNAP transcribing most Escherichia coli genes, RfaH regulates just a few operons containing ops, a DNA sequence that mediates RfaH recruitment. Here, we describe the
Georgiy A, Belogurov +4 more
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TRIM28 as a novel transcriptional elongation factor [PDF]
BMC Molecular Biology, 2015 TRIM28 is a multidomain protein with versatile functions in transcription and DNA repair. Recently it was shown that this factor plays unanticipated roles in transcriptional elongation. TRIM28 was shown to stabilize the pausing of RNA polymerase II (Pol II) close to the transcriptional start site in many unactivated genes, permitting Pol II ...
Heeyoun Bunch, Stuart K Calderwood
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Translational repression by a transcriptional elongation factor [PDF]
Genes & Development, 1997 One of the classical positive regulators of gene expression is bacteriophage λ N protein. N regulates the transcription of early phage genes by participating in the formation of a highly processive, terminator-resistant transcription complex and thereby stimulates the expression of genes lying downstream of transcriptional terminators. Also included in
H R, Wilson +4 more
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Transcription Factor E Is a Part of Transcription Elongation Complexes [PDF]
Journal of Biological Chemistry, 2007 A homologue of the N-terminal domain of the alpha subunit of the general eukaryotic transcription factor TFE is encoded in the genomes of all sequenced archaea, but the position of archaeal TFE in transcription complexes has not yet been defined.
Sebastian, Grünberg +3 more
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Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome
Viruses, 2020 Human immunodeficiency virus type-1 (HIV-1) can either undergo a lytic pathway to cause productive systemic infections or enter a latent state in which the integrated provirus remains transcriptionally silent for decades. The ability to latently infect T-
Joseph Hokello +2 more
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DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. [PDF]
, 2020 Despite reductions in mortality from the use of highly active antiretroviral therapy (HAART), the presence of latent or transcriptionally silent proviruses prevents HIV cure/eradication.
Bukrinsky, Michael +10 more
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