Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults [PDF]
BMC Genomics, 2017 Background Transcriptional elongation is a generic function, but is also regulated to allow rapid transcription responses. Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following ...
Haiwang Yang +3 more
doaj +3 more sources
Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control [PDF]
Advanced Science, EarlyView.Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang +9 more
wiley +2 more sources
Transcription Factor E Is a Part of Transcription Elongation Complexes [PDF]
Journal of Biological Chemistry, 2007 A homologue of the N-terminal domain of the alpha subunit of the general eukaryotic transcription factor TFE is encoded in the genomes of all sequenced archaea, but the position of archaeal TFE in transcription complexes has not yet been defined.
Sebastian, Grünberg +3 more
openaire +2 more sources
Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state. [PDF]
PLoS GeneticsDuring zebrafish embryonic body elongation, differentiation of mesodermal progenitors into presomitic mesoderm requires the transcription factors tbx16 and mesogenin 1.
Guoyu Zhu +5 more
doaj +2 more sources
Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome
Viruses, 2020 Human immunodeficiency virus type-1 (HIV-1) can either undergo a lytic pathway to cause productive systemic infections or enter a latent state in which the integrated provirus remains transcriptionally silent for decades. The ability to latently infect T-
Joseph Hokello +2 more
doaj +1 more source
Nature Communications, 2022 The PNUTS-PP1 complex directly binds to RNA, and interacts with polymerase II and RNA processing factors to control transcriptional elongation rates and slow polymerase II after polyadenylation sites to promote termination.
Anne M. Devlin +8 more
doaj +1 more source
A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]
, 2014 There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T +3 more
core +1 more source
HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies
Molecules, 2018 Transcription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency.
Kaori Asamitsu +2 more
doaj +1 more source
An investigation of a role for U2 snRNP spliceosomal components in regulating transcription. [PDF]
PLoS ONE, 2011 There is mounting evidence to suggest that the synthesis of pre-mRNA transcripts and their subsequent splicing are coordinated events. Previous studies have implicated the mammalian spliceosomal U2 snRNP as having a novel role in stimulating ...
Susannah L McKay, Tracy L Johnson
doaj +1 more source
P-TEFb: The master regulator of transcription elongation
Molecules and Cells, 2022 The positive transcription elongation factor b (P-TEFb) is composed of cyclins T1 or T2 and cyclin dependent kinase 9 that regulate the elongation phase of transcription by RNA polymerase II.
K. Fujinaga, Fang Huang, B. Peterlin
semanticscholar +1 more source