Transcription Factor E Is a Part of Transcription Elongation Complexes [PDF]
Journal of Biological Chemistry, 2007 A homologue of the N-terminal domain of the alpha subunit of the general eukaryotic transcription factor TFE is encoded in the genomes of all sequenced archaea, but the position of archaeal TFE in transcription complexes has not yet been defined.
Sebastian, Grünberg +3 more
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Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome
Viruses, 2020 Human immunodeficiency virus type-1 (HIV-1) can either undergo a lytic pathway to cause productive systemic infections or enter a latent state in which the integrated provirus remains transcriptionally silent for decades. The ability to latently infect T-
Joseph Hokello +2 more
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Nature Communications, 2022 The PNUTS-PP1 complex directly binds to RNA, and interacts with polymerase II and RNA processing factors to control transcriptional elongation rates and slow polymerase II after polyadenylation sites to promote termination.
Anne M. Devlin +8 more
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HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies
Molecules, 2018 Transcription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency.
Kaori Asamitsu +2 more
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An investigation of a role for U2 snRNP spliceosomal components in regulating transcription. [PDF]
PLoS ONE, 2011 There is mounting evidence to suggest that the synthesis of pre-mRNA transcripts and their subsequent splicing are coordinated events. Previous studies have implicated the mammalian spliceosomal U2 snRNP as having a novel role in stimulating ...
Susannah L McKay, Tracy L Johnson
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The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma [PDF]
Cell Death & Disease, 2020 AbstractTCEA3 is one of three genes representing the transcription elongation factor TFIIS family in vertebrates. TCEA3 is upregulated during skeletal muscle differentiation and acts to promote muscle specific gene expression during myogenesis. Rhabdomyosarcoma (RMS) is a pediatric cancer derived from the muscle lineage, but the expression or function ...
Noor Kazim +3 more
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LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis
eLife, 2014 Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Xiaodan Ji +3 more
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Time-resolved analysis of transcription kinetics in single live mammalian cells
Frontiers in Physics, 2022 In eukaryotic cells, RNA polymerase II synthesizes mRNA in three stages, initiation, elongation, and termination, and numerous factors determine how quickly a gene is transcribed to produce mRNA molecules through these steps.
Hongyoung Choi +4 more
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The elongation factor RfaH and the initiation factor σ bind to the same site on the transcription elongation complex [PDF]
Proceedings of the National Academy of Sciences, 2008 RNA polymerase is a target for numerous regulatory events in all living cells. Recent studies identified a few “hot spots” on the surface of bacterial RNA polymerase that mediate its interactions with diverse accessory proteins. Prominent among these hot spots, the β′ subunit clamp helices serve as a major binding site for the initiation factor σ and ...
Anastasiya, Sevostyanova +3 more
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The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]
, 2007 Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
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