Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults [PDF]
BMC Genomics, 2017 Background Transcriptional elongation is a generic function, but is also regulated to allow rapid transcription responses. Following relatively long initiation and promoter clearance, RNA polymerase II can pause and then rapidly elongate following ...
Haiwang Yang +3 more
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The transcription elongation factors Spt4 and Spt6 promote dermal adipocyte differentiation [PDF]
AdipocyteRegulation of adipogenesis has classically been viewed through the lens of transcription initiation driven by lineage defining transcription factors.
Julian Gomez +6 more
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DNA topological regulation in RNA polymerase II transcription [PDF]
Cellular & Molecular Biology LettersRNA polymerase II (Pol II) is the main enzyme that synthesizes protein-coding messenger RNA and a subset of nonprotein coding RNA molecules based on the DNA sequences harboring genetic information in eukaryotes.
Heeyoun Bunch
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Nature Communications, 2022 The PNUTS-PP1 complex directly binds to RNA, and interacts with polymerase II and RNA processing factors to control transcriptional elongation rates and slow polymerase II after polyadenylation sites to promote termination.
Anne M. Devlin +8 more
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An investigation of a role for U2 snRNP spliceosomal components in regulating transcription. [PDF]
PLoS ONE, 2011 There is mounting evidence to suggest that the synthesis of pre-mRNA transcripts and their subsequent splicing are coordinated events. Previous studies have implicated the mammalian spliceosomal U2 snRNP as having a novel role in stimulating ...
Susannah L McKay, Tracy L Johnson
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HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies
Molecules, 2018 Transcription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency.
Kaori Asamitsu +2 more
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The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma [PDF]
Cell Death & Disease, 2020 AbstractTCEA3 is one of three genes representing the transcription elongation factor TFIIS family in vertebrates. TCEA3 is upregulated during skeletal muscle differentiation and acts to promote muscle specific gene expression during myogenesis. Rhabdomyosarcoma (RMS) is a pediatric cancer derived from the muscle lineage, but the expression or function ...
Noor Kazim +3 more
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Time-resolved analysis of transcription kinetics in single live mammalian cells
Frontiers in Physics, 2022 In eukaryotic cells, RNA polymerase II synthesizes mRNA in three stages, initiation, elongation, and termination, and numerous factors determine how quickly a gene is transcribed to produce mRNA molecules through these steps.
Hongyoung Choi +4 more
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The elongation factor RfaH and the initiation factor σ bind to the same site on the transcription elongation complex [PDF]
Proceedings of the National Academy of Sciences, 2008 RNA polymerase is a target for numerous regulatory events in all living cells. Recent studies identified a few “hot spots” on the surface of bacterial RNA polymerase that mediate its interactions with diverse accessory proteins. Prominent among these hot spots, the β′ subunit clamp helices serve as a major binding site for the initiation factor σ and ...
Anastasiya, Sevostyanova +3 more
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The prefoldin complex regulates chromatin dynamics during transcription elongation. [PDF]
PLoS Genetics, 2013 Transcriptional elongation requires the concerted action of several factors that allow RNA polymerase II to advance through chromatin in a highly processive manner.
Gonzalo Millán-Zambrano +6 more
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