Results 21 to 30 of about 8,550,429 (348)

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis

eLife, 2014
Transcriptional elongation by RNA polymerase (Pol) II is essential for gene expression during cell growth and differentiation. The positive transcription elongation factor b (P-TEFb) stimulates transcriptional elongation by phosphorylating Pol II and ...
Xiaodan Ji, Huasong Lu, Qiang Zhou, Kunxin Luo   +3 more
doaj   +1 more source

Time-resolved analysis of transcription kinetics in single live mammalian cells

Frontiers in Physics, 2022
In eukaryotic cells, RNA polymerase II synthesizes mRNA in three stages, initiation, elongation, and termination, and numerous factors determine how quickly a gene is transcribed to produce mRNA molecules through these steps.
Hongyoung Choi, Byung Hun Lee, Hye Yoon Park, Hye Yoon Park, Hye Yoon Park   +4 more
doaj   +1 more source

The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]

, 2007
Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
core   +1 more source

The prefoldin complex regulates chromatin dynamics during transcription elongation. [PDF]

PLoS Genetics, 2013
Transcriptional elongation requires the concerted action of several factors that allow RNA polymerase II to advance through chromatin in a highly processive manner.
Gonzalo Millán-Zambrano, Alfonso Rodríguez-Gil, Xenia Peñate, Lola de Miguel-Jiménez, Macarena Morillo-Huesca, Nevan Krogan, Sebastián Chávez   +6 more
doaj   +1 more source

The elongation factor RfaH and the initiation factor σ bind to the same site on the transcription elongation complex [PDF]

Proceedings of the National Academy of Sciences, 2008
RNA polymerase is a target for numerous regulatory events in all living cells. Recent studies identified a few “hot spots” on the surface of bacterial RNA polymerase that mediate its interactions with diverse accessory proteins. Prominent among these hot spots, the β′ subunit clamp helices serve as a major binding site for the initiation factor σ and ...
Anastasiya, Sevostyanova, Vladimir, Svetlov, Dmitry G, Vassylyev, Irina, Artsimovitch   +3 more
openaire   +2 more sources

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma

Nature, 2017
Glioblastoma is a universally lethal cancer with a median survival time of approximately 15 months. Despite substantial efforts to define druggable targets, there are no therapeutic options that notably extend the lifespan of patients with glioblastoma ...
Tyler E. Miller, Brian B Liau, Lisa C. Wallace, Andrew R. Morton, Qi Xie, Deobrat Dixit, Daniel C. Factor, Leo J. Y. Kim, James J. Morrow, Qiulian Wu, S. Mack, C. Hubert, Shawn M. Gillespie, William A. Flavahan, Thomas Hoffmann, Rohit Thummalapalli, M. Hemann, P. Paddison, C. Horbinski, J. Zuber, P. Scacheri, B. Bernstein, P. Tesar, J. Rich   +23 more
semanticscholar   +1 more source

The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma [PDF]

Cell Death & Disease, 2020
AbstractTCEA3 is one of three genes representing the transcription elongation factor TFIIS family in vertebrates. TCEA3 is upregulated during skeletal muscle differentiation and acts to promote muscle specific gene expression during myogenesis. Rhabdomyosarcoma (RMS) is a pediatric cancer derived from the muscle lineage, but the expression or function ...
Noor Kazim, Abhinav Adhikari, Teak Jung Oh, Judith Davie   +3 more
openaire   +2 more sources

Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing

Frontiers in Immunology, 2023
IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis.
Morgan W. Mann, Yao Fu, Robert L. Gearhart, Xiaofang Xu, David S. Roberts, Yi Li, Jia Zhou, Ying Ge, Ying Ge, Ying Ge, Allan R. Brasier, Allan R. Brasier   +11 more
doaj   +1 more source

Jasmonate-regulated root growth inhibition and root hair elongation

Journal of Experimental Botany, 2022
The phytohormone jasmonate is an essential endogenous signal in the regulation of multiple plant processes for environmental adaptation, such as primary root growth inhibition and root hair elongation.
Xiao Han, Mengyi Kui, Kunrong He, Milian Yang, Jiancan Du, Yan-Juan Jiang, Yanru Hu   +6 more
semanticscholar   +1 more source

Transcriptional termination enhances protein expression in human cells [PDF]

, 2009
Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage ...
Proudfoot, Nicholas J, West, S, Proudfoot, NJ, West, Steven, Proudfoot, Nicholas   +4 more
core   +1 more source