Results 41 to 50 of about 8,550,429 (348)

Inhibition of the Super Elongation Complex Suppresses Herpes Simplex Virus Immediate Early Gene Expression, Lytic Infection, and Reactivation from Latency

mBio, 2020
Induction of herpes simplex virus (HSV) immediate early (IE) gene transcription promotes the initiation of lytic infection and reactivation from latency in sensory neurons. IE genes are transcribed by the cellular RNA polymerase II (RNAPII) and regulated
Roberto Alfonso-Dunn, Jesse H. Arbuckle, Jodi L. Vogel, Thomas M. Kristie   +3 more
doaj   +1 more source

Structure and Function of the Human Transcription Elongation Factor DSIF [PDF]

Journal of Biological Chemistry, 1999
5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) is a classic inhibitor of transcription elongation by RNA polymerase II (pol II). We have previously identified and purified a novel transcription elongation factor, termed DSIF (for DRB sensitivity-inducing factor), that makes transcription sensitive to DRB.
Yamaguchi, Y., Wada, T., Watanabe, D., Takagi, T., Hasegawa, J., Handa, H.   +5 more
openaire   +2 more sources

Transcription elongation is finely tuned by dozens of regulatory factors

eLife, 2022
Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NET-seq) in 41 strains of Saccharomyces cerevisiae
Kate C Lachance, Kevin M Harlen, Mary Couvillion, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman   +7 more
openaire   +3 more sources

Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression [PDF]

, 2011
Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known
Renate Renkawitz-Pohl, Hassler Markus, Murawska, Magdalena, Ladurner Andreas, Brehm Alexander, Andreas Ladurner, Renkawitz-Pohl, Renate, Brehm, Alexander, Ladurner, Andreas, Magdalena Murawska, Murawska Magdalena, Markus Hassler, Hassler, Markus, Alexander Brehm, Renkawitz-Pohl Renate   +14 more
core   +2 more sources

Subgenic Pol II interactomes identify region‐specific transcription elongation regulators

Molecular Systems Biology, 2017
Transcription, RNA processing, and chromatin‐related factors all interact with RNA polymerase II (Pol II) to ensure proper timing and coordination of transcription and co‐transcriptional processes.
Kevin M Harlen, L Stirling Churchman
doaj   +1 more source

Evolutionary importance of translation elongation factor eEF1A variant switching:eEF1A1 down-regulation in muscle is conserved in Xenopus but is controlled at a post-transcriptional level [PDF]

, 2011
Translation elongation isoform eEF1A1 has a pivotal role in protein synthesis and is almost ubiquitously expressed. In mice and rats that transcription of the gene encoding eEF1A1 is downregulated to undetectable levels in muscle after weaning; eEF1A1 is
Catherine M. Abbott, Stancheva, Irina, Abbott, Catherine M, Newbery, Helen J, Helen J. Newbery, Irina Stancheva, Zimmerman, Lyle B, Lyle B. Zimmerman   +7 more
core   +1 more source

Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II Via Transcriptional Elongation Control in Mitosis

Molecules and Cells, 2015
Summary Although it is established that some general transcription factors are inactivated at mitosis, many details of Mitotic Inhibition of Transcription (MIT) and its underlying mechanisms are largely unknown. We have identified Mitotic Transcriptional
Kaiwei Liang, Ashley R Woodfin, Brian D. Slaughter, J. Unruh, A. Box, Ryan A. Rickels, Xin Gao, J. Haug, Sue L. Jaspersen, A. Shilatifard   +9 more
semanticscholar   +1 more source

Synthetic transcription elongation factors license transcription across repressive chromatin [PDF]

Science, 2017
Chemical control of transcription Friedreich's ataxia, a devastating neurodegenerative disease with no effective therapy, is caused by an expansion of intronic repeats and hence a reduced expression of the FXN gene. Erwin et al.
Graham S. Erwin, Matthew P. Grieshop, Asfa Ali, Jun Qi, Matthew Lawlor, Deepak Kumar, Istaq Ahmad, Anna McNally, Natalia Teider, Katie Worringer, Rajeev Sivasankaran, Deeba N. Syed, Asuka Eguchi, Md. Ashraf, Justin Jeffery, Mousheng Xu, Paul M. C. Park, Hasan Mukhtar, Achal K. Srivastava, Mohammed Faruq, James E. Bradner, Aseem Z. Ansari   +21 more
openaire   +2 more sources

Promoter Architecture and Transcriptional Regulation of Genes Upregulated in Germination and Coleoptile Elongation of Diverse Rice Genotypes Tolerant to Submergence

Frontiers in Genetics, 2021
Rice has the natural morphological adaptation to germinate and elongate its coleoptile under submerged flooding conditions. The phenotypic deviation associated with the tolerance to submergence at the germination stage could be due to natural variation ...
Bijayalaxmi Mohanty
doaj   +1 more source

4sUDRB-seq: measuring genomewide transcriptional elongation rates and initiation frequencies within cells

Genome Biology, 2014
Although transcriptional elongation by RNA polymerase II is coupled with many RNA-related processes, genomewide elongation rates remain unknown. We describe a method, called 4sUDRB-seq, based on reversible inhibition of transcription elongation coupled ...
G. Fuchs, Yoav Voichek, S. Benjamin, S. Gilad, I. Amit, M. Oren   +5 more
semanticscholar   +1 more source