Nature Communications, 2023 Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators and preinitiation complexes to initiate eukaryotic transcription, but this time course is usually not visualized.
Chun-Yi Cho, Patrick H. O’Farrell
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Involvement of Transcription Termination Factor 2 in Mitotic Repression of Transcription Elongation [PDF]
Molecular Cell, 2004 All nuclear transcription is interrupted during mitosis. We examined the role of human TTF2, an RNA polymerase (Pol) I and II termination factor, in mitotic repression of transcription elongation. We find that TTF2 levels rise in the cytoplasm in S and G2 and at the onset of mitosis TTF2 translocates into the nucleus.
Jiang, Yan +3 more
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Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]
, 2010 It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
Ellis Peter +75 more
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ISWI and CHD chromatin remodelers bind promoters but act in gene bodies. [PDF]
PLoS Genetics, 2013 ATP-dependent nucleosome remodelers influence genetic processes by altering nucleosome occupancy, positioning, and composition. In vitro, Saccharomyces cerevisiae ISWI and CHD remodelers require ∼30-85 bp of extranucleosomal DNA to reposition nucleosomes,
Gabriel E Zentner +2 more
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Synthetic transcription elongation factors license transcription across repressive chromatin [PDF]
Science, 2017 Chemical control of transcription Friedreich's ataxia, a devastating neurodegenerative disease with no effective therapy, is caused by an expansion of intronic repeats and hence a reduced expression of the FXN gene. Erwin et al.
Graham S. Erwin +21 more
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A splicing-dependent transcriptional checkpoint associated with prespliceosome formation
, 2014 There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T +3 more
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Functional analysis and binding affinity of tomato ethylene response factors provide insight on the molecular bases of plant differential responses to ethylene [PDF]
, 2012 Background : The phytohormone ethylene is involved in a wide range of developmental processes and in mediating plant responses to biotic and abiotic stresses.
Ohme-Takagi Masaru +33 more
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Perturbation of chromatin structure globally affects localization and recruitment of splicing factors [PDF]
, 2012 Chromatin structure is an important factor in the functional coupling between transcription and mRNA processing, not only by regulating alternative splicing events, but also by contributing to exon recognition during constitutive splicing.
Risso, Guillermo, J +47 more
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Coupling of Transcription and Translation in Archaea: Cues From the Bacterial World
Frontiers in Microbiology, 2021 The lack of a nucleus is the defining cellular feature of bacteria and archaea. Consequently, transcription and translation are occurring in the same compartment, proceed simultaneously and likely in a coupled fashion.
Albert Weixlbaumer +7 more
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Over-expression of a chimeric gene of the transcriptional co-activator MBF1 fused to the EAR repressor motif causes developmental alteration in Arabidopsis and tomato [PDF]
, 2008 Transcriptional co-activators of the Multiprotein Bridging Factor1 (MBF1) type belong to a multigenic family that encode key components of the machinery controlling gene expression by communicating between transcription factors and the basal ...
Regad, Farid +8 more
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