Results 61 to 70 of about 106,553 (310)

NDF is a transcription factor that stimulates elongation by RNA polymerase II

Genes & Development, 2022
RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes.
Jia Fei, Jun Xu, Ziwei Li, Kevin Xu, Dong Wang, George A. Kassavetis, James T. Kadonaga   +6 more
openaire   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Different elongation factors distinctly modulate RNA polymerase II transcription in Arabidopsis [PDF]

, 2023
Various transcript elongation factors (TEFs) including modulators of RNA polymerase II (RNAPII) activity and histone chaperones tune the efficiency of transcription in the chromatin context.
Grasser, Klaus D., Obermeyer, Simon, Schwartz, Uwe, Stöckl, Richard, Schrettenbrunner, Lukas   +4 more
core   +1 more source

Alternative Splicing and Transcription Elongation in Plants

Frontiers in Plant Science, 2019
Alternative splicing and transcription elongation by RNA polymerase II (RNAPII) are two processes which are tightly connected. Splicing is a co-transcriptional process, and different experimental approaches show that splicing is coupled to transcription ...
Micaela A. Godoy Herz, Micaela A. Godoy Herz, Alberto R. Kornblihtt, Alberto R. Kornblihtt   +3 more
doaj   +1 more source

The Transcription Factor THO Promotes Transcription Initiation and Elongation by RNA Polymerase I [PDF]

Journal of Biological Chemistry, 2016
Although ribosomal RNA represents the majority of cellular RNA, and ribosome synthesis is closely connected to cell growth and proliferation rates, a complete understanding of the factors that influence transcription of ribosomal DNA is lacking. Here, we show that the THO complex positively affects transcription by RNA polymerase I (Pol I).
Yinfeng, Zhang, Sarah L, French, Ann L, Beyer, David A, Schneider   +3 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc [PDF]

, 2009
HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3. Most eukaryotes express at least three isoforms of HP1 with similar domain architecture.
Eskeland, Ragnhild, RAFFA, GRAZIA DANIELA, Eskeland Ragnhild, Abel, Jochen, Jochen Abel, Raffa Grazia D., Raffa, Grazia D, Ragnhild Eskeland, Abel Jochen, Kremmer Elisabeth, Abel, J., Imhof Axel, Raffa, G.D., Ragnhild Eskel, Imhof, Axel, Eskeland, R., Grazia D. Raffa, Kremmer, E., Imhof, A., Kremmer, Elisabeth, Axel Imhof, Grazia D Raffa, Elisabeth Kremmer   +22 more
core   +1 more source

The Block to Transcription Elongation at the Minute Virus of Mice Attenuator Is Regulated by Cellular Elongation Factors [PDF]

Molecular and Cellular Biology, 1991
We have previously reported that both in vivo and in vitro, RNA polymerase II pauses or prematurely terminates transcription at a specific attenuation site located 142 to 147 nucleotides downstream from the P4 promoter of minute virus of mice (MVM). In this report, we show that an in vitro block to transcription elongation in HeLa whole-cell extract ...
A, Krauskopf, E, Bengal, Y, Aloni
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Transcript elongation by RNA polymerase II in plants: factors, regulation and impact on gene expression [PDF]

, 2023
Transcriptional elongation by RNA polymerase II (RNAPII) through chromatin is a dynamic and highly regulated step of eukaryotic gene expression. A combination of transcript elongation factors (TEFs) including modulators of RNAPII activity and histone ...
Grasser, Klaus D., Obermeyer, Simon, Markusch, Hanna, Kapoor, Henna   +3 more
core   +1 more source