Results 61 to 70 of about 8,550,429 (348)

Eukaryotic translation elongation factor 1A (eEF1A) domain I from S. cerevisiae is required but not sufficient for inter-species complementation [PDF]

, 2012
Ethanolamine phosphoglycerol (EPG) is a protein modification attached exclusively to eukaryotic elongation factor 1A (eEF1A). In mammals and plants, EPG is linked to conserved glutamate residues located in eEF1A domains II and III, whereas in the ...
Heller, M., Sandra Eltschinger (147134), Manfred Heller (128679), Greganova, Eva, Michael Altmann, Eva Greganova (147137), Bütikofer Peter, Altmann, M., Bütikofer, Peter, Heller Manfred, Eltschinger, Sandra, Sandra Eltschinger, Altmann Michael, Peter Bütikofer, Michael Altmann (39486), Bütikofer, P., Eltschinger, S., Eltschinger Sandra, Altmann, Michael, Heller, Manfred, Greganova Eva, Manfred Heller, Eva Greganova, Greganova, E., Peter Bütikofer (147146)   +24 more
core   +3 more sources

Transcriptional elongation checkpoint control in development and disease.

Genes & Development, 2013
Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development.
Edwin R. Smith, A. Shilatifard
semanticscholar   +1 more source

Transcriptional control: Tat cofactors and transcriptional elongation [PDF]

, 1998
HIV-1 gene expression requires the transactivator Tat, which stimulates viral transcript elongation. Recent results show that two cellular cyclin-dependent kinases, which phosphorylate the carboxy-terminal domain of the RNA polymerase II large subunit ...
Yankulov, Krassimir, Bentley, David
core   +1 more source

Coupling of Transcription and Translation in Archaea: Cues From the Bacterial World

Frontiers in Microbiology, 2021
The lack of a nucleus is the defining cellular feature of bacteria and archaea. Consequently, transcription and translation are occurring in the same compartment, proceed simultaneously and likely in a coupled fashion.
Albert Weixlbaumer, Albert Weixlbaumer, Albert Weixlbaumer, Albert Weixlbaumer, Felix Grünberger, Finn Werner, Dina Grohmann, Dina Grohmann   +7 more
doaj   +1 more source

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

Nature, 2019
The synthesis of pre-mRNA by RNA polymerase II (Pol II) involves the formation of a transcription initiation complex, and a transition to an elongation complex1–4. The large subunit of Pol II contains an intrinsically disordered C-terminal domain that is
Y. Guo, John C. Manteiga, J. Henninger, Benjamin R. Sabari, Alessandra Dall’Agnese, N. Hannett, J. Spille, Lena K. Afeyan, A. V. Zamudio, K. Shrinivas, B. Abraham, Ann Boija, T. Decker, Jenna K. Rimel, Charli B. Fant, Tong Ihn Lee, I. Cissé, P. Sharp, D. Taatjes, R. Young   +19 more
semanticscholar   +1 more source

The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]

, 2015
RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core   +1 more source

Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation

Cell Reports, 2013
The transition from transcription initiation into elongation is controlled by transcription factors, which recruit positive transcription elongation factor b (P-TEFb) to promoters to phosphorylate RNA polymerase II.
Ryan P. McNamara, Jennifer L. McCann, Swapna Aravind Gudipaty, Iván D’Orso   +3 more
doaj   +1 more source

Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5′- and 3′ ends

Cell Reports
Summary: CDK7 regulates RNA polymerase II (RNAPII) initiation, elongation, and termination through incompletely understood mechanisms. Because contaminating kinases prevent reliable CDK7 analysis with nuclear extracts, we reconstitute RNAPII ...
Olivia Luyties, Lynn Sanford, Jessica Rodino, Michael Nagel, Taylor Jones, Jenna K. Rimel, Christopher C. Ebmeier, Megan Palacio, Grace S. Shelby, Kira Cozzolino, Finn Brennan, Axel Hartzog, Mirzam B. Saucedo, Lotte P. Watts, Sabrina Spencer, Jennifer F. Kugel, Robin D. Dowell, Dylan J. Taatjes   +17 more
doaj   +1 more source

O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β*

Journal of Biological Chemistry, 2016
We describe here the identification and functional characterization of the enzyme O-GlcNAcase (OGA) as an RNA polymerase II elongation factor. Using in vitro transcription elongation assays, we show that OGA activity is required for elongation in a crude
M. Resto, Bong-Hyun Kim, Alfonso G. Fernandez, B. Abraham, Keji Zhao, B. Lewis   +5 more
semanticscholar   +1 more source

Transcription Elongation Factors in Health and Disease

, 2022
Gene expression is a complex process that establishes and maintains a specific cell state. Transcription, an early event during the gene expression, is fine-tuned by a concerted action of a plethora of transcription factors temporally and spatially in response to various stimuli.
openaire   +1 more source