Results 81 to 90 of about 8,550,429 (348)

Human Negative Elongation Factor Activates Transcription and Regulates Alternative Transcription Initiation [PDF]

Journal of Biological Chemistry, 2010
The human negative elongation factor (NELF) is a four-subunit protein complex that inhibits the movement of RNA polymerase II (RNAPII) at an early elongation stage in vitro. NELF-mediated stalling of RNAPII also attenuates transcription of a number of inducible genes in human cells.
Jianlong, Sun, Rong, Li
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway

Journal of Molecular Biology, 2011
Latent HIV proviruses are thought to be primarily reactivated in vivo through stimulation of the T-cell receptor (TCR). Activation of the T-cell receptor (TCR) induces multiple signal transduction pathways leading to the ordered nuclear migration of the ...
Young Kyeung Kim, Uri Mbonye, Joseph Hokello, J. Karn   +3 more
semanticscholar   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Functional analysis and binding affinity of tomato ethylene response factors provide insight on the molecular bases of plant differential responses to ethylene [PDF]

, 2012
Background : The phytohormone ethylene is involved in a wide range of developmental processes and in mediating plant responses to biotic and abiotic stresses.
Ohme-Takagi Masaru, Mila Isabelle, Mondher Bouzayen, Pirrello, Julien, Mila, Isabelle, Latché Alain, Zhang Wangshu, Chen Kunsong, Chen, Kunsong, Ohme-Takagi, Masaru, Bouzayen Mondher, Prasad, Narasimha, Masaru Ohme-Takagi, Zouine, Mohamed, BC Narasimha Prasad, Regad, Farid, Regad Farid, Jean Claude Pech, Kunsong Chen, Farid Regad, Pirrello Julien, Isabelle Mila, Prasad BC Narasimha, Pech Jean Claude, Alain Latché, Mohamed Zouine, Bouzayen, Mondher, Wangshu Zhang, Latché, Alain, Pech, Jean-Claude, Julien Pirrello, Zouine Mohamed, Zhang, Wangshu, Julien Pirrello   +33 more
core   +1 more source

p53 Interacts with RNA polymerase II through its core domain and impairs Pol II processivity in vivo. [PDF]

PLoS ONE, 2011
The tumor suppressor p53 principally functions as a gene-specific transcription factor. p53 triggers a variety of anti-proliferative programs by activating or repressing the transcription of effector genes in response to genotoxic stress.
Sunyoung Kim, Sri Kripa Balakrishnan, David S Gross   +2 more
doaj   +1 more source

The Transcription Factor THO Promotes Transcription Initiation and Elongation by RNA Polymerase I [PDF]

Journal of Biological Chemistry, 2016
Although ribosomal RNA represents the majority of cellular RNA, and ribosome synthesis is closely connected to cell growth and proliferation rates, a complete understanding of the factors that influence transcription of ribosomal DNA is lacking. Here, we show that the THO complex positively affects transcription by RNA polymerase I (Pol I).
Yinfeng, Zhang, Sarah L, French, Ann L, Beyer, David A, Schneider   +3 more
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

An evolutionary ratchet leading to loss of elongation factors in eukaryotes [PDF]

, 2014
Background The GTPase eEF1A is the eukaryotic factor responsible for the essential, universal function of aminoacyl-tRNA delivery to the ribosome.
Kamenski, Piotr, Atkinson, Gemma C.,, Atkinson, Gemma C., Soosaar, Axel, Hauryliuk, Vasili,, Ivan Chicherin, Martin Carr, Tenson, Tanel,, Vasili Hauryliuk, Carr, Martin, Tanel Tenson, Kamenski, Piotr,, Kuzmenko, Anton, Hauryliuk, Vasili, Tenson, Tanel, Kuzmenko, Anton,, Chicherin, Ivan,, Carr, Martin,, Piotr Kamenski, Gemma C Atkinson, Soosaar, Axel,, Anton Kuzmenko, Lund University., Axel Soosaar, Chicherin, Ivan   +24 more
core   +1 more source

Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation

mBio, 2023
Transcription of herpes simplex virus 1 (HSV-1) immediate early (IE) genes is controlled at multiple levels by the cellular transcriptional coactivator, HCF-1.
Jesse H. Arbuckle, Jodi L. Vogel, Stacey Efstathiou, Thomas M. Kristie   +3 more
doaj   +1 more source