Results 51 to 60 of about 8,550,429 (348)

Structure of the Complete RNA Polymerase II Elongation Complex and its Interaction with the Elongation Factor TFIIS [PDF]

, 2005
This thesis describes crystal structures of complete, 12-subunit yeast RNA polymerase II (Pol II) in complex with a synthetic transcription bubble and product RNA, with an NTP substrate analogue, and in complex with the transcription elongation factor ...
Kettenberger, Hubert
core   +1 more source

EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity

Platelets, 2022
Megakaryocytes (MKs) are the unique non-pathological cells that undergo polyploidization in mammals. The polyploid formation is critical for understanding the MK biology, and transcriptional regulation is involved in the differentiation and maturation of
Lanyue Hu, Weiwei Zhang, Zheng Xiang, Yali Wang, Cheng Zeng, Xiaojie Wang, Chengning Tan, Yichi Zhang, Fengjie Li, Yanni Xiao, Luping Zhou, Jiuxuan Li, Chun Wu, Yang Xiang, Lixin Xiang, Xiaomei Zhang, Xueying Wang, Wuchen Yang, Maoshan Chen, Qian Ran, Zhongjun Li, Li Chen   +21 more
doaj   +1 more source

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes

Cell Reports, 2014
SUMMARY Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity. Here, we demonstrate that BRD4, a member of the bromodomain and extraterminal domain (BET) family of epigenetic readers ...
R. D. Micco, Bárbara Fontanals-Cirera, V. Low, P. Ntziachristos, Stephanie Yuen, Claudia D. Lovell, Igor Dolgalev, Y. Yonekubo, Guangtao Zhang, E. Rusinova, G. Gerona-Navarro, M. Cañamero, M. Ohlmeyer, I. Aifantis, Ming-Ming Zhou, A. Tsirigos, E. Hernando   +16 more
semanticscholar   +1 more source

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α [PDF]

, 2013
Interleukin-1β and Tumor Necrosis Factor α play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the rapidly expressed genes (IL1B ...
Unlu, Sebnem, Gillian M. Tannahill (440532), O’Neill Luke A., Kent Z. Q. Wang (440530), Kent Z. Q. Wang, Galson, Deborah L., Galson Deborah L., Luke A. O’Neill (440534), Tannahill Gillian M., Auron Philip E., O'Neill, LA, Adamik, Juraj, Su An-Jey A., Gillian M. Tannahill, Sebnem Unlu, Philip E. Auron, Unlu Sebnem, Gillian M Tannahill, Adamik, J, An-Jey A. Su, Yan, Chunhong, Auron, PE, Deborah L. Galson, Luke A. O’Neill, Luke A O'Neill, O’Neill, Luke A., Su, AJA, Tannahill, GM, An-Jey A. Su (440531), O\u27Neill, Luke A., Deborah L Galson, Wang, KZQ, An-Jey A Su, Kent Z Q Wang, Unlu, S, Sebnem Unlu (156119), Wang, Kent Z. Q., Juraj Adamik (440529), Galson, DL, Adamik Juraj, Philip E. Auron (440535), Philip E Auron, Wang Kent Z. Q., Su, An Jey A., Tannahill, Gillian M., Su, An-Jey A., Wang, Kent Z.Q., Deborah L. Galson (440533), Auron, Philip E., Juraj Adamik   +49 more
core   +1 more source

Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription

Nature Communications, 2023
Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators and preinitiation complexes to initiate eukaryotic transcription, but this time course is usually not visualized.
Chun-Yi Cho, Patrick H. O’Farrell
doaj   +1 more source

Double overexpression of DREB and PIF transcription factors improves drought stress tolerance and cell elongation in transgenic plants

Plant Biotechnology Journal, 2016
Summary Although a variety of transgenic plants that are tolerant to drought stress have been generated, many of these plants show growth retardation.
Madoka Kudo, Satoshi Kidokoro, T. Yoshida, J. Mizoi, D. Todaka, A. Fernie, K. Shinozaki, K. Yamaguchi-Shinozaki   +7 more
semanticscholar   +1 more source

Tumorigenesis: Transcriptional elongation and cancer [PDF]

, 1996
Recent discoveries indicate that transcriptional elongation is an important regulatory step in gene expression, and that deregulation of elongation can lead to the development of certain ...
Green, Michael R., Li, Xiao-Yong
core   +1 more source

ISWI and CHD chromatin remodelers bind promoters but act in gene bodies. [PDF]

PLoS Genetics, 2013
ATP-dependent nucleosome remodelers influence genetic processes by altering nucleosome occupancy, positioning, and composition. In vitro, Saccharomyces cerevisiae ISWI and CHD remodelers require ∼30-85 bp of extranucleosomal DNA to reposition nucleosomes,
Gabriel E Zentner, Toshio Tsukiyama, Steven Henikoff   +2 more
doaj   +1 more source

Control of Transcriptional Elongation

Annual Review of Genetics, 2013
Elongation is becoming increasingly recognized as a critically controlled step in transcriptional regulation. While traditional genetic and biochemical studies have identified major players of transcriptional elongation, our understanding of the ...
Hojoong Kwak, J. Lis
semanticscholar   +1 more source

Involvement of Transcription Termination Factor 2 in Mitotic Repression of Transcription Elongation [PDF]

Molecular Cell, 2004
All nuclear transcription is interrupted during mitosis. We examined the role of human TTF2, an RNA polymerase (Pol) I and II termination factor, in mitotic repression of transcription elongation. We find that TTF2 levels rise in the cytoplasm in S and G2 and at the onset of mitosis TTF2 translocates into the nucleus.
Jiang, Yan, Liu, Mingyi, Spencer, Charlotte A., Price, David H.   +3 more
openaire   +2 more sources