Results 51 to 60 of about 192,584 (302)

Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote [PDF]

, 2017
In many plants, the asymmetric division of the zygote sets up the apical-basal axis of the embryo. Unlike animals, plant zygotes are transcriptionally active, implying that plants have evolved specific mechanisms to control transcriptional activation of ...
Aichinger, Ernst, De Smet, Ive, Gong, Wen, Groot, Edwin, Higashiyama, Tetsuya, Laux, Thomas, Ueda, Minako, Umeda, Masaaki, Verstraeten, Inge, Vu, Lam Dai   +9 more
core   +2 more sources

Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer [PDF]

, 2014
The three Akt isoforms are functionally distinct. Here we show that their phosphoproteomes also differ, suggesting that their functional differences are due to differences in target specificity.
Ailan Guo, Bild, Cai, Carstens, Carvalho, Chen, Chen, Cho, Christos Polytarchou, Conrad, Cooper, Dimitrios Iliopoulos, Duina, Ezell, Filippos Kottakis, Franke, Gowher, Iliopoulos, Ioannis Sanidas, Jianxin Xie, Kalsotra, Kolasinska-Zwierz, Kottakis, Krogan, Kumar, Lan Hu, Luco, Luco, Manning, Maria Hatziapostolou, Maroulakou, Michael J. Comb, Miki, Moore, Moshkin, Orr-Urtreger, Peña, Philip N. Tsichlis, Polytarchou, Scott A. Ezell, Thiery, Tschopp, Wan, Wang, Warzecha, Xie, Yoh, Yoh, Zhang, Zhou   +49 more
core   +1 more source

Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation

Cell Reports, 2013
The transition from transcription initiation into elongation is controlled by transcription factors, which recruit positive transcription elongation factor b (P-TEFb) to promoters to phosphorylate RNA polymerase II.
Ryan P. McNamara, Jennifer L. McCann, Swapna Aravind Gudipaty, Iván D’Orso   +3 more
doaj   +1 more source

Multi-omics and biochemical reconstitution reveal CDK7-dependent mechanisms controlling RNA polymerase II function at gene 5′- and 3′ ends

Cell Reports
Summary: CDK7 regulates RNA polymerase II (RNAPII) initiation, elongation, and termination through incompletely understood mechanisms. Because contaminating kinases prevent reliable CDK7 analysis with nuclear extracts, we reconstitute RNAPII ...
Olivia Luyties, Lynn Sanford, Jessica Rodino, Michael Nagel, Taylor Jones, Jenna K. Rimel, Christopher C. Ebmeier, Megan Palacio, Grace S. Shelby, Kira Cozzolino, Finn Brennan, Axel Hartzog, Mirzam B. Saucedo, Lotte P. Watts, Sabrina Spencer, Jennifer F. Kugel, Robin D. Dowell, Dylan J. Taatjes   +17 more
doaj   +1 more source

Gre factors help Salmonella adapt to oxidative stress by improving transcription elongation and fidelity of metabolic genes.

PLoS Biology, 2023
Detoxification, scavenging, and repair systems embody the archetypical antioxidant defenses of prokaryotic and eukaryotic cells. Metabolic rewiring also aids with the adaptation of bacteria to oxidative stress.
Sashi Kant, James Karl A Till, Lin Liu, Alyssa Margolis, Siva Uppalapati, Ju-Sim Kim, Andres Vazquez-Torres   +6 more
doaj   +1 more source

Evolutionary importance of translation elongation factor eEF1A variant switching:eEF1A1 down-regulation in muscle is conserved in Xenopus but is controlled at a post-transcriptional level [PDF]

, 2011
Translation elongation isoform eEF1A1 has a pivotal role in protein synthesis and is almost ubiquitously expressed. In mice and rats that transcription of the gene encoding eEF1A1 is downregulated to undetectable levels in muscle after weaning; eEF1A1 is
Abbott, Catherine M, Newbery, Helen J, Stancheva, Irina, Zimmerman, Lyle B   +3 more
core   +1 more source

Retention of Transcription Initiation Factor σ70 in Transcription Elongation: Single-Molecule Analysis [PDF]

Molecular Cell, 2005
We report a single-molecule assay that defines, simultaneously, the translocational position of a protein complex relative to DNA and the subunit stoichiometry of the complex. We applied the assay to define translocational positions and sigma70 contents of bacterial transcription elongation complexes in vitro.
Kapanidis, A N, Margeat, E, Laurence, T A, Doose, S, Ho, S O, Mukhopadhyay, J, Kortkhonjia, E, Mekler, V, Ebright, R H, Weiss, S   +9 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Human Negative Elongation Factor Activates Transcription and Regulates Alternative Transcription Initiation [PDF]

Journal of Biological Chemistry, 2010
The human negative elongation factor (NELF) is a four-subunit protein complex that inhibits the movement of RNA polymerase II (RNAPII) at an early elongation stage in vitro. NELF-mediated stalling of RNAPII also attenuates transcription of a number of inducible genes in human cells.
Jianlong, Sun, Rong, Li
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source