Results 31 to 40 of about 192,584 (302)

Transcription elongation is finely tuned by dozens of regulatory factors

eLife, 2022
Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NET-seq) in 41 strains of Saccharomyces cerevisiae
Kate C Lachance, Kevin M Harlen, Mary Couvillion, Kristine L Trotta, Erin Smith, Christian Brion, Brendan M Smalec, L Stirling Churchman   +7 more
openaire   +3 more sources

A link between transcription fidelity and pausing in vivo [PDF]

, 2017
Pausing by RNA polymerase is a major mechanism that regulates transcription elongation but can cause conflicts with fellow RNA polymerases and other cellular machineries. Here, we summarize our recent finding that misincorporation could be a major source
Gamba, Pamela, James, Katherine, Zenkin, Nikolay   +2 more
core   +2 more sources

Trithorax group proteins: switching genes on and keeping them active [PDF]

, 2011
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein ...
Cavalli, G., Iovino, N., Martinez, A., Schuettengruber, B.   +3 more
core   +1 more source

NusG inhibits RNA polymerase backtracking by stabilizing the minimal transcription bubble

eLife, 2016
Universally conserved factors from NusG family bind at the upstream fork junction of transcription elongation complexes and modulate RNA synthesis in response to translation, processing, and folding of the nascent RNA.
Matti Turtola, Georgiy A Belogurov
doaj   +1 more source

Inhibition of the Super Elongation Complex Suppresses Herpes Simplex Virus Immediate Early Gene Expression, Lytic Infection, and Reactivation from Latency

mBio, 2020
Induction of herpes simplex virus (HSV) immediate early (IE) gene transcription promotes the initiation of lytic infection and reactivation from latency in sensory neurons. IE genes are transcribed by the cellular RNA polymerase II (RNAPII) and regulated
Roberto Alfonso-Dunn, Jesse H. Arbuckle, Jodi L. Vogel, Thomas M. Kristie   +3 more
doaj   +1 more source

Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene [PDF]

, 2012
The MYB proto-oncogene is expressed in most estrogen receptor-positive (ERα +) breast tumors and cell lines. Expression of MYB is controlled, in breast cancer and other cell types, by a transcriptional pausing mechanism involving an attenuation site ...
Anderson, Bender, Bender, Berry, Biroccio, Bjornstrom, Buratowski, Byers, Carroll, Chao, Chodosh, De Falco, Drabsch, Drabsch, Frasor, Gilmour, Gonda, Guerin, Hugo, Jin, Kephart, Kininis, Krueger, Lloyd A. Pereira, Long, Lukasiak, Margaritis, Miao, Nechaev, Partha Mitra, Peterlin, Robert G. Ramsay, Stadhouders, Thomas J. Gonda, Thompson, Torelli, Trainer, Wang, Watson, Welboren, Wittmann, Xue, Yang, Yik, Yik, Yik, Yvette Drabsch, Zhou, Zuber   +48 more
core   +2 more sources

Subgenic Pol II interactomes identify region‐specific transcription elongation regulators

Molecular Systems Biology, 2017
Transcription, RNA processing, and chromatin‐related factors all interact with RNA polymerase II (Pol II) to ensure proper timing and coordination of transcription and co‐transcriptional processes.
Kevin M Harlen, L Stirling Churchman
doaj   +1 more source

Control of translation elongation in health and disease

Disease Models & Mechanisms, 2020
Regulation of protein synthesis makes a major contribution to post-transcriptional control pathways. During disease, or under stress, cells initiate processes to reprogramme protein synthesis and thus orchestrate the appropriate cellular response. Recent
John R. P. Knight, Gavin Garland, Tuija Pöyry, Emma Mead, Nikola Vlahov, Aristeidis Sfakianos, Stefano Grosso, Fabio De-Lima-Hedayioglu, Giovanna R. Mallucci, Tobias von der Haar, C. Mark Smales, Owen J. Sansom, Anne E. Willis   +12 more
doaj   +1 more source

Promoter Architecture and Transcriptional Regulation of Genes Upregulated in Germination and Coleoptile Elongation of Diverse Rice Genotypes Tolerant to Submergence

Frontiers in Genetics, 2021
Rice has the natural morphological adaptation to germinate and elongate its coleoptile under submerged flooding conditions. The phenotypic deviation associated with the tolerance to submergence at the germination stage could be due to natural variation ...
Bijayalaxmi Mohanty
doaj   +1 more source

Characterisation of the ERF102 to ERF105 genes of Arabidopsis thaliana and their role in the response to cold stress [PDF]

, 2020
The ETHYLENE RESPONSE FACTOR (ERF) genes of Arabidopsis thaliana form a large family encoding plant-specific transcription factors. Here, we characterise the four phylogenetically closely related ERF102/ERF5, ERF103/ERF6, ERF104 and ERF105 genes ...
Hincha, Dirk K., Illgen, Sylvia, Schmülling, Thomas, Zintl, Stefanie, Zuther, Ellen   +4 more
core   +1 more source