Results 21 to 30 of about 737 (163)

The Y of cancer sex differences [PDF]

Clin Transl Med, 2023
Clinical and Translational Medicine, Volume 13, Issue 9, September 2023.
Jiexi Li, Ronald A. DePinho
wiley   +2 more sources

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration [PDF]

Journal of Cell Science, 2008
Loss-of-function mutations in the IKBKAP gene, which encodes IKAP (ELP1), cause familial dysautonomia (FD), with defective neuronal development and maintenance. Molecular mechanisms leading to FD are poorly understood. We demonstrate that various RNA-interference-based depletions of IKAP lead to defective adhesion and migration in several cell types ...
Marja Jäättelä, Jukka Westermarck, Tuula Kallunki   +2 more
exaly   +3 more sources

Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation. [PDF]

PLoS ONE, 2015
A splicing mutation in the IKBKAP gene causes Familial Dysautonomia (FD), affecting the IKAP protein expression levels and proper development and function of the peripheral nervous system (PNS).
Sharon Lefler, Malkiel A Cohen, Gal Kantor, David Cheishvili, Aviel Even, Anastasya Birger, Tikva Turetsky, Yaniv Gil, Sharona Even-Ram, Einat Aizenman, Nibal Bashir, Channa Maayan, Aharon Razin, Benjamim E Reubinoff, Miguel Weil   +14 more
doaj   +2 more sources

Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression. [PDF]

PLoS Genetics, 2013
Mouse Ikbkap gene encodes IKAP--one of the core subunits of Elongator--and is thought to be involved in transcription. However, the biological function of IKAP, particularly within the context of an animal model, remains poorly characterized.
Fu-Jung Lin, Li Shen, Chuan-Wei Jang, Pål Ø Falnes, Yi Zhang   +4 more
doaj   +3 more sources

Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells. [PDF]

PLoS ONE, 2010
Familial Dysautonomia (FD) is an autosomal recessive congenital neuropathy that results from abnormal development and progressive degeneration of the sensory and autonomic nervous system.
Hadas Keren, Maya Donyo, David Zeevi, Channa Maayan, Tal Pupko, Gil Ast   +5 more
doaj   +2 more sources

Viral mimicry evasion: a new role for oncogenic KRAS mutations [PDF]

Molecular Oncology, Volume 19, Issue 2, Page 271-274, February 2025.
“Viral mimicry” is a potent anticancer mechanism involving innate immune activation by endogenous nucleic acids like double‐stranded RNA (dsRNA). Zhou and colleagues report viral mimicry evasion as a novel function of oncogenic KRAS mutations by suppressing the RNA helicase DDX60, leading to poor immune checkpoint therapy responses.
Raymond Chen, Aobo He, Daniel D. De Carvalho   +2 more
wiley   +2 more sources

The influence of the IKAP nursing model on wound healing following vacuum sealing drainage in acute infective endocarditis: a retrospective study [PDF]

Frontiers in Cardiovascular Medicine
BackgroundAcute infective endocarditis (IE) presents clinical challenges due to its complex pathophysiology and potential for severe complications. Vacuum sealing drainage (VSD) is an essential treatment approach, and nursing care plays a pivotal role in
Xichun Zhang, Yingli Shi, Yan Yang
doaj   +2 more sources

IKAP—Identifying K mAjor cell Population groups in single-cell RNA-sequencing analysis [PDF]

GigaScience, 2019
Abstract Background In single-cell RNA-sequencing analysis, clustering cells into groups and differentiating cell groups by differentially expressed (DE) genes are 2 separate steps for investigating cell identity.
Clare Sun, Mehdi Pirooznia, Komudi Singh   +2 more
exaly   +4 more sources

The IκB Kinase (IKK) Complex Is Tripartite and Contains IKKγ but Not IKAP as a Regular Component [PDF]

Journal of Biological Chemistry, 2000
A critical step in the activation of NF-κB is the phosphorylation of IκBs by the IκB kinase (IKK) complex. IKKα and IKKβ are the two catalytic subunits of the IKK complex and two additional molecules, IKKγ/NEMO and IKAP, have been described as further integral members. We have analyzed the function of both proteins for IKK complex composition and NF-κB
Daniel Krappmann, Claus Scheidereit, Anke Klippel   +2 more
exaly   +2 more sources

Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality. [PDF]

PLoS ONE, 2011
Familial Dysautonomia (FD) is an autosomal recessive disorder that affects 1/3,600 live births in the Ashkenazi Jewish population, and leads to death before the age of 40.
Paula Dietrich, Junming Yue, Shuyu E, Ioannis Dragatsis   +3 more
doaj   +2 more sources