Results 191 to 200 of about 6,778,674 (329)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity

Molecular Pain
Background: IL-1β plays a critical role in the pathophysiology of neuroinflammation. The presence of cleaved IL-1β (cIL-1β) in the neurons of the dorsal root ganglion (DRG) implicates its function in biological signaling arising from the sensory neuron ...
Daisuke Fujita, Yutaka Matsuoka, Shunsuke Yamakita, Yasuhiko Horii, Daiki Ishikawa, Kohsuke Kushimoto, Hiroaki Amino, Fumimasa Amaya   +7 more
doaj   +1 more source

Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway

Virus Research
Background: Human metapneumovirus(hMPV) is one of the most common viruses that cause acute lower respiratory tract infections. Interleukin-1β (IL-1β) has been reported to play an important role in multiple virus replication.
Guojin Wu, Yueyan Zhang, Linlin Niu, Yuan Hu, Yuting Yang, Yao Zhao   +5 more
doaj   +1 more source

Exosomes from IL-1β-Primed Mesenchymal Stem Cells Inhibited IL-1β- and TNF-α-Mediated Inflammatory Responses in Osteoarthritic SW982 Cells

Tissue Engineering and Regenerative Medicine, 2021
Mijin Kim, Dong Il Shin, B. Choi, Byoung-Hyun Min   +3 more
semanticscholar   +1 more source

Biosensor for IL-1β imaging

, 2012
©2012. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Journal of Immunology.
Verkhratsky, Alexei, Compan, Vincent, Bragg, Laricia, Pelegrin, Pablo, Baroja-Mazo, Alberto, Perroy, Julie   +5 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Water intake regulates mucosal immunity in rat jejunal villi via IL‐1β, IL‐6, and IL‐10

Physiological Reports
We had demonstrated that the intragastric administration of distilled water increased male rat jejunal lymph flow and interleukin‐22 levels in the lymph, resulting in the promotion of innate immunity.
Norika Kuneshita, Yuki Sakai, Moyuru Hayashi, Tomomi Watanabe‐Asaka, Daisuke Maejima, Yoshiko Kawai, Toshio Ohhashi   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

IL-1β-induced ERK1/2 phosphorylation and its inhibition by an ERK1/2 inhibitor.

, 2019
In dermal fibroblasts treated with 100 pM IL-1β for 0–60 min, ERK1/2 phosphorylation (p-ERK1/2) was observed in a time-dependent manner (a, b). IL-1β had no effect on total ERK1/2 (t-ERK1/2) expression (a).
Taku Kitanaka (3350276), Tomohiro Nakayama (30894), Nanako Kitanaka (3350285), Tadayoshi Konno (3350282), Kanae Sugiura (7042421), Hiroshi Sugiya (412101), Rei Nakano (820735), Shinichi Namba (3350288)   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source