Results 301 to 310 of about 6,778,674 (329)

Elevated postoperative IL-1β induces disorder of intestinal microenvironment and alteration of gut microbiota. [PDF]

Front Microbiol
Wang W, Liao X, Liu J, Liu B, Zhou C, Liang P.   +5 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Adenosine 5'-monophosphate prevents sepsis-associated muscle wasting by activating AMPK and suppressing IL-1β inflammatory cytokines. [PDF]

J Intensive Care
Yoshihara I, Yoshihara N, Hanafusa K, Sueyoshi K, Ono Y, Umei N, Watanabe S, Okamoto K, Tanaka H, Kondo Y.   +9 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

TRABD2A promotes osteogenic differentiation of human periodontal ligament stem cells by modulating TNF-α and IL-1β. [PDF]

Organogenesis
Lu H, Xu X, Guo Y, Tang L, Chen J, Lin S.   +5 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Isoforskolin inhibits LUBAC/GSDMD/IL-1β cascades in pulmonary fibrosis. [PDF]

J Thorac Dis
He B, He H, Li L, Liu X, Wen Y, Hua S, Sun S.   +6 more
europepmc   +1 more source

Neutrophil NADPH oxidase breaks the inflammatory IL-1β/IL-17A circuit to enhance pathogen clearance during respiratory virus infections. [PDF]

Nat Commun
Sofoluwe A, Petropoulos A, Ali-Khan ZF, Goomanee AS, Cleary SJ, Warnatsch A.   +5 more
europepmc   +1 more source

IL-1β contributes to neurological disability in NMOSD AQP4 + Patients. [PDF]

Neurol Sci
Bruno A, Borrelli A, Lauritano G, Di Lemme S, Di Caprio V, Fantozzi R, Dolcetti E, Azzolini F, Gilio L, Galifi G, Furlan R, Finardi A, De Vito F, Musella A, Mandolesi G, Bassi MS, Centonze D, Buttari F.   +17 more
europepmc   +1 more source

FKBP5 Orchestrates a Biphasic Microglial Response in Spinal Cord Injury by Sequentially Activating the GPR84/IL-1β Pathway and the LDHA-Lactylation-FXYD5/LGALS1 Axis. [PDF]

Research (Wash D C)
Li H, Wang J, Li D, Bi H, Yang J, Dong J, Gong Z, Gong H, Wang B, Chen L.   +9 more
europepmc   +1 more source