Results 101 to 110 of about 15,170,590 (380)

UNDERSTANDING THE NEUROINFLAMMATORY RESPONSE FOLLOWING CONCUSSION TO DEVELOP TREATMENT STRATEGIES

Frontiers in Cellular Neuroscience, 2012
Mild traumatic brain injuries (mTBI) have been associated with long-term cognitive deficits relating to trauma-induced neurodegeneration. These long-term deficits include impaired memory and attention, changes in executive function, emotional instability
Zachary Robert Patterson, Matthew R Holahan   +1 more
doaj   +1 more source

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression

Journal of Experimental Medicine, 1991
Interleukin 10 (IL-10) and viral IL-10 (v-IL-10) strongly reduced antigen-specific proliferation of human T cells and CD4+ T cell clones when monocytes were used as antigen-presenting cells.
R. D. Malefyt, J. Haanen, H. Spits, M. Roncarolo, A. Velde, C. Figdor, K. E. Johnson, R. Kastelein, H. Yssel, J. D. Vries   +9 more
semanticscholar   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

Impact of IL-10 and IL-12B single nucleotide polymorphisms on circulating cytokine level in development of Hashimoto's thyroiditis

Biotechnology & Biotechnological Equipment, 2016
Hashimoto's thyroiditis (HT) is an organ-specific, mainly Th1 autoimmune disorder. New evidence has accumulated for involvement of Treg-produced cytokines.
Julieta Gerenova, Irena Manolova, Spaska Stanilova   +2 more
doaj   +1 more source

Cytokine dynamics in vitiligo: the roles of interleukin-10 and interleukin-17 [PDF]

Exploration of Immunology
Aim: Vitiligo is an autoimmune skin disorder characterized by melanocyte destruction and progressive depigmentation. Cytokine imbalance plays a key role in its pathogenesis.
Hanan Mohammed Saied
doaj   +1 more source

Dietary fat-induced taurocholic acid production promotes pathobiont and colitis in IL-10−/− mice

Nature, 2012
The composite human microbiome of Western populations has probably changed over the past century, brought on by new environmental triggers that often have a negative impact on human health.
Suzanne Devkota, Yunwei Wang, M. Musch, V. Leone, H. Fehlner-Peach, A. Nadimpalli, D. Antonopoulos, B. Jabri, E. Chang   +8 more
semanticscholar   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Koch, Alexander, Hamann, Lutz, Schott, Matthias, Boehm, Olaf, Grotemeyer, Dirk, Kurt, Muhammed, Schwenke, Carsten, Schumann, Ralf R., Bornstein, Stefan R., Zacharowski, Kai   +9 more
core   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

Gene sequences of IL-1B and IL-10 of Eris patients associated with Toxoplasmosis [PDF]

Journal of Medical and Life Science
In this case-control study, 100 patients infected with Eris were recruited in Al-Numan Hospital in Baghdad City, and 50 healthy persons were also selected as a control group from July 2024 to August 2024. The results observed no important variations (P=0.
Ammer Mohammed, Nazar Mohammed, Khalied Zakair   +2 more
doaj   +1 more source

IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

Nature Communications, 2017
Interleukin 35 (IL-35) is a heterodimeric cytokine composed of IL-12p35 and Ebi3 subunits. IL-35 suppresses autoimmune diseases while preventing host defense to infection and promoting tumor growth and metastasis by converting resting B and T cells into ...
I. Dambuza, Chang He, J. K. Choi, C. Yu, R. Wang, M. Mattapallil, P. Wingfield, R. Caspi, C. Egwuagu   +8 more
semanticscholar   +1 more source