Results 91 to 100 of about 1,832,666 (293)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Usage of IFNγ or TNFα-T in protocols for obtaining cytokine-induced killer cells for adoptive immunotherapy

Медицинская иммунология
Methods of immunocorrection based on injection of in vitro activated autologous leukocytes are becoming widespread. Our previous studies suggest that implementation of immunotherapy with in vitro activated lymphocytes using cytokines is effective for the
Yu. V. Gelm, L. Yu. Grivtsova, I. A. Pasova, Т. V. Konstantinova, Т. Yu. Mushkarina, S. A. Ivanov, A. D. Kaprin   +6 more
doaj   +1 more source

Tuft cell–produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation

, 2021
Saltanat Ualiyeva, Evan Lemire, Evelyn C. Avilés, Caitlin Wong, Amelia Boyd, Juying Lai, Tao Liu, Ichiro Matsumoto, Nora A. Barrett, Joshua A. Boyce, Adam L. Haber, Lora G. Bankova   +11 more
openalex   +2 more sources

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection [PDF]

, 2021
Alistair Chenery, Silvia Rosini, James E Parkinson, Jesuthas Ajendra, Jeremy Herrera, Craig Lawless, Brian H. K. Chan, P’ng Loke, Andrew S. MacDonald, Karl E. Kadler, Thang V. Pham, Judith E. Allen   +11 more
openalex   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma

OncoImmunology, 2018
Background: Approximately 50% of melanomas harbor BRAF mutations. Treatment with BRAF +/− MEK inhibition is associated with favorable changes in the tumor microenvironment thus providing the rationale for combining targeted agents with immunotherapy ...
Meghan J. Mooradian, Alexandre Reuben, Peter A. Prieto, Mehlika Hazar-Rethinam, Dennie T. Frederick, Brandon Nadres, Adriano Piris, Vikram Juneja, Zachary A. Cooper, Arlene H. Sharpe, Ryan B. Corcoran, Keith T. Flaherty, Donald P. Lawrence, Jennifer A. Wargo, Ryan J. Sullivan   +14 more
doaj   +1 more source

TLR9–IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction

, 2020
Yusuke Murakami, Takashi Ishii, Hiroki Nunokawa, Keigo Kurata, Tomoya Narita, Naomi Yamashita   +5 more
openalex   +1 more source

Functional dissection of the cytoplasmic subregions of the IL-2 receptor beta c chain in primary lymphocyte populations [PDF]

, 1998
Hodaka Fujii
openalex   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source